The effect of vascular origin, oxygen, and tumour necrosis factor alpha on trophoblast invasion of maternal arteries in vitro

Extravillous trophoblasts (EVTs) invade and remodel uterine spiral arteries. Regulatory factors may include inherent vessel susceptibility, local oxygen levels and tumour necrosis factor alpha (TNFα). We have used an in vitro model to investigate interstitial and endovascular invasion of myometrial...

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Veröffentlicht in:	The Journal of pathology 2005-08, Vol.206 (4), p.476-485
Hauptverfasser:	Crocker, Ian P, Wareing, Mark, Ferris, Glenn R, Jones, Carolyn J, Cartwright, Judith E, Baker, Philip N, Aplin, John D
Format:	Artikel
Sprache:	eng
Schlagworte:	Arteries Biological and medical sciences Cell Aggregation - physiology Cell Differentiation - physiology Cell Movement - physiology Cells, Cultured Coculture Techniques - methods Endothelium, Vascular - physiology Female Humans invasion Investigative techniques, diagnostic techniques (general aspects) Medical sciences Microscopy, Electron - methods Microscopy, Fluorescence - methods Models, Biological Muscle, Smooth, Vascular - physiology Muscle, Smooth, Vascular - ultrastructure Myometrium - blood supply Omentum - blood supply oxygen Oxygen - physiology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques placenta Placenta - cytology Placental Circulation - physiology Placentation - physiology Pregnancy Pregnancy Trimester, First spiral arteries TNFα trophoblast Trophoblasts - physiology Trophoblasts - ultrastructure Tumor Necrosis Factor-alpha - physiology
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