Mutational analysis of action of mitochondrial fusion factor mitofusin-2

Mitofusin-2 (Mfn2) is an essential component of mitochondrial fusion machinery, but its molecular mechanism of action is not clear. We found that a Mfn2 deletion mutant lacking two transmembrane spans (Mfn[superscript [Delta]TM]) acts as a dominant-negative mutant and blocks mitochondrial fusion. Fu...

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Veröffentlicht in:	Journal of cell science 2005-07, Vol.118 (14), p.3153-3161
Hauptverfasser:	Honda, Shinji, Aihara, Takeshi, Hontani, Masayasu, Okubo, Katsuhiko, Hirose, Shigehisa
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Cell Line Cercopithecus aethiops Conserved Sequence COS Cells Gene Deletion GTP Phosphohydrolases - genetics GTP Phosphohydrolases - metabolism Humans Immunoprecipitation Intracellular Membranes - enzymology Intracellular Membranes - physiology Mammalia Membrane Potentials - physiology Mice Mitochondria - enzymology Mitochondria - genetics Mitochondria - physiology Molecular Sequence Data Mutation Nematoda Protein Structure, Tertiary Transfection
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