Does apoptosis occur in amyotrophic lateral sclerosis? TUNEL experience from human amyotrophic lateral sclerosis (ALS) tissues
The role that apoptosis plays in the pathogenesis of amyotrophic lateral sclerosis (ALS) is still unclear. From our autopsy samples, we have undertaken an effort to verify if apoptosis in ALS really occurs or if can at least be detected. The study was performed using TUNEL method for screening the a...
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| Veröffentlicht in: | Folia neuropathologica 2005, Vol.43 (2), p.75-80 |
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| creator | Tomik, Barbara Adamek, Dariusz Pierzchalski, Piotr Banares, Steven Duda, Aleksandra Partyka, Dorota Pawlik, Wiesław Kałuza, Józef Krajewski, Stan Szczudlik, Andrzej |
| description | The role that apoptosis plays in the pathogenesis of amyotrophic lateral sclerosis (ALS) is still unclear. From our autopsy samples, we have undertaken an effort to verify if apoptosis in ALS really occurs or if can at least be detected. The study was performed using TUNEL method for screening the apoptotic changes in the autopsy samples from 8 ALS cases compared with 16 control cases. No features of apoptosis (DNA cleavages) were noted in any of the investigated regions of the central nervous system in ALS cases as well as in controls. These preliminary results seem to support the reports, which deny the role of apoptosis in human ALS. The following investigations using additional methods will be performed for detection the apoptotic signals in ALS. |
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TUNEL experience from human amyotrophic lateral sclerosis (ALS) tissues</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Tomik, Barbara ; Adamek, Dariusz ; Pierzchalski, Piotr ; Banares, Steven ; Duda, Aleksandra ; Partyka, Dorota ; Pawlik, Wiesław ; Kałuza, Józef ; Krajewski, Stan ; Szczudlik, Andrzej</creator><creatorcontrib>Tomik, Barbara ; Adamek, Dariusz ; Pierzchalski, Piotr ; Banares, Steven ; Duda, Aleksandra ; Partyka, Dorota ; Pawlik, Wiesław ; Kałuza, Józef ; Krajewski, Stan ; Szczudlik, Andrzej</creatorcontrib><description>The role that apoptosis plays in the pathogenesis of amyotrophic lateral sclerosis (ALS) is still unclear. From our autopsy samples, we have undertaken an effort to verify if apoptosis in ALS really occurs or if can at least be detected. The study was performed using TUNEL method for screening the apoptotic changes in the autopsy samples from 8 ALS cases compared with 16 control cases. No features of apoptosis (DNA cleavages) were noted in any of the investigated regions of the central nervous system in ALS cases as well as in controls. These preliminary results seem to support the reports, which deny the role of apoptosis in human ALS. The following investigations using additional methods will be performed for detection the apoptotic signals in ALS.</description><identifier>ISSN: 1641-4640</identifier><identifier>PMID: 16012908</identifier><language>eng</language><publisher>Poland</publisher><subject>Aged ; Amyotrophic Lateral Sclerosis - pathology ; Apoptosis - physiology ; Brain - pathology ; Female ; Humans ; In Situ Nick-End Labeling ; Male ; Middle Aged ; Motor Neurons - pathology</subject><ispartof>Folia neuropathologica, 2005, Vol.43 (2), p.75-80</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16012908$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tomik, Barbara</creatorcontrib><creatorcontrib>Adamek, Dariusz</creatorcontrib><creatorcontrib>Pierzchalski, Piotr</creatorcontrib><creatorcontrib>Banares, Steven</creatorcontrib><creatorcontrib>Duda, Aleksandra</creatorcontrib><creatorcontrib>Partyka, Dorota</creatorcontrib><creatorcontrib>Pawlik, Wiesław</creatorcontrib><creatorcontrib>Kałuza, Józef</creatorcontrib><creatorcontrib>Krajewski, Stan</creatorcontrib><creatorcontrib>Szczudlik, Andrzej</creatorcontrib><title>Does apoptosis occur in amyotrophic lateral sclerosis? TUNEL experience from human amyotrophic lateral sclerosis (ALS) tissues</title><title>Folia neuropathologica</title><addtitle>Folia Neuropathol</addtitle><description>The role that apoptosis plays in the pathogenesis of amyotrophic lateral sclerosis (ALS) is still unclear. From our autopsy samples, we have undertaken an effort to verify if apoptosis in ALS really occurs or if can at least be detected. The study was performed using TUNEL method for screening the apoptotic changes in the autopsy samples from 8 ALS cases compared with 16 control cases. No features of apoptosis (DNA cleavages) were noted in any of the investigated regions of the central nervous system in ALS cases as well as in controls. These preliminary results seem to support the reports, which deny the role of apoptosis in human ALS. The following investigations using additional methods will be performed for detection the apoptotic signals in ALS.</description><subject>Aged</subject><subject>Amyotrophic Lateral Sclerosis - pathology</subject><subject>Apoptosis - physiology</subject><subject>Brain - pathology</subject><subject>Female</subject><subject>Humans</subject><subject>In Situ Nick-End Labeling</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Motor Neurons - pathology</subject><issn>1641-4640</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0DtPwzAUBWAPIFoKfwF5QjBE8jv1hKpSHlIEA-0c3Tg3qlFSBzuR6MJvpwiYO93lO-dI94RMuVE8U0axCTlP6Z0xpZUVZ2TCDePCsvmUfN0HTBT60A8h-USDc2Okfkeh24chhn7rHW1hwAgtTa7F-MPu6HrzsioofvYYPe4c0iaGjm7HDo5E6c2ieLulg09pxHRBThtoE17-3RnZPKzWy6eseH18Xi6KrBeKDVmV10I4LkAwk1cNs7aqQJsKlAFtJXfcMeTS5lAZp3EOTBto8hxlXte50XJGrn97-xg-DrtD2fnksG1hh2FMpZkzobllR6HgUmqj5AFe_cGx6rAu--g7iPvy_7XyGzwadiU</recordid><startdate>2005</startdate><enddate>2005</enddate><creator>Tomik, Barbara</creator><creator>Adamek, Dariusz</creator><creator>Pierzchalski, Piotr</creator><creator>Banares, Steven</creator><creator>Duda, Aleksandra</creator><creator>Partyka, Dorota</creator><creator>Pawlik, Wiesław</creator><creator>Kałuza, Józef</creator><creator>Krajewski, Stan</creator><creator>Szczudlik, Andrzej</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>2005</creationdate><title>Does apoptosis occur in amyotrophic lateral sclerosis? TUNEL experience from human amyotrophic lateral sclerosis (ALS) tissues</title><author>Tomik, Barbara ; Adamek, Dariusz ; Pierzchalski, Piotr ; Banares, Steven ; Duda, Aleksandra ; Partyka, Dorota ; Pawlik, Wiesław ; Kałuza, Józef ; Krajewski, Stan ; Szczudlik, Andrzej</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p240t-b7d22c12a2067bf099bba56ba46a5931c1c0e1397ab6c5e8a056af77e37dd7653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Aged</topic><topic>Amyotrophic Lateral Sclerosis - pathology</topic><topic>Apoptosis - physiology</topic><topic>Brain - pathology</topic><topic>Female</topic><topic>Humans</topic><topic>In Situ Nick-End Labeling</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Motor Neurons - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tomik, Barbara</creatorcontrib><creatorcontrib>Adamek, Dariusz</creatorcontrib><creatorcontrib>Pierzchalski, Piotr</creatorcontrib><creatorcontrib>Banares, Steven</creatorcontrib><creatorcontrib>Duda, Aleksandra</creatorcontrib><creatorcontrib>Partyka, Dorota</creatorcontrib><creatorcontrib>Pawlik, Wiesław</creatorcontrib><creatorcontrib>Kałuza, Józef</creatorcontrib><creatorcontrib>Krajewski, Stan</creatorcontrib><creatorcontrib>Szczudlik, Andrzej</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Folia neuropathologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tomik, Barbara</au><au>Adamek, Dariusz</au><au>Pierzchalski, Piotr</au><au>Banares, Steven</au><au>Duda, Aleksandra</au><au>Partyka, Dorota</au><au>Pawlik, Wiesław</au><au>Kałuza, Józef</au><au>Krajewski, Stan</au><au>Szczudlik, Andrzej</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Does apoptosis occur in amyotrophic lateral sclerosis? TUNEL experience from human amyotrophic lateral sclerosis (ALS) tissues</atitle><jtitle>Folia neuropathologica</jtitle><addtitle>Folia Neuropathol</addtitle><date>2005</date><risdate>2005</risdate><volume>43</volume><issue>2</issue><spage>75</spage><epage>80</epage><pages>75-80</pages><issn>1641-4640</issn><abstract>The role that apoptosis plays in the pathogenesis of amyotrophic lateral sclerosis (ALS) is still unclear. From our autopsy samples, we have undertaken an effort to verify if apoptosis in ALS really occurs or if can at least be detected. The study was performed using TUNEL method for screening the apoptotic changes in the autopsy samples from 8 ALS cases compared with 16 control cases. No features of apoptosis (DNA cleavages) were noted in any of the investigated regions of the central nervous system in ALS cases as well as in controls. These preliminary results seem to support the reports, which deny the role of apoptosis in human ALS. The following investigations using additional methods will be performed for detection the apoptotic signals in ALS.</abstract><cop>Poland</cop><pmid>16012908</pmid><tpages>6</tpages></addata></record> |
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| ispartof | Folia neuropathologica, 2005, Vol.43 (2), p.75-80 |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Aged Amyotrophic Lateral Sclerosis - pathology Apoptosis - physiology Brain - pathology Female Humans In Situ Nick-End Labeling Male Middle Aged Motor Neurons - pathology |
| title | Does apoptosis occur in amyotrophic lateral sclerosis? TUNEL experience from human amyotrophic lateral sclerosis (ALS) tissues |
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