Familial influences on basal salivary cortisol in an adult population
To understand the underlying genetic and environmental sources of individual variation in basal cortisol levels, we collected salivary cortisol at awakening and at six fixed time points during the day in adult twins and their singleton siblings. Reported time of awakening was verified with heart rat...
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| Veröffentlicht in: | Psychoneuroendocrinology 2005-10, Vol.30 (9), p.857-868 |
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| container_title | Psychoneuroendocrinology |
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| creator | Kupper, Nina de Geus, Eco J.C. van den Berg, Mireille Kirschbaum, Clemens Boomsma, Dorret I. Willemsen, Gonneke |
| description | To understand the underlying genetic and environmental sources of individual variation in basal cortisol levels, we collected salivary cortisol at awakening and at six fixed time points during the day in adult twins and their singleton siblings. Reported time of awakening was verified with heart rate and body movement recordings. Cortisol data were available for 199 MZ twins, 272 DZ twins and 229 singleton siblings from 309 twin families. No differences in cortisol means and variances were found between twins and singleton siblings. Additionally, the correlations for DZ twins and siblings were not significantly different, indicating generalizability of twin study results to the general population. Genetic model fitting showed heritability for cortisol levels during the awakening period (34% for cortisol level at awakening and 32% for cortisol level at 30
min after awakening) but not for cortisol levels later during the day. The current study shows that, while cortisol levels in the awakening period are influenced by genetic factors, cortisol levels throughout most of the day are not heritable, indicating that future gene finding studies for basal cortisol should focus on the first hour post-awakening. |
| doi_str_mv | 10.1016/j.psyneuen.2005.04.003 |
| format | Article |
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min after awakening) but not for cortisol levels later during the day. The current study shows that, while cortisol levels in the awakening period are influenced by genetic factors, cortisol levels throughout most of the day are not heritable, indicating that future gene finding studies for basal cortisol should focus on the first hour post-awakening.</description><identifier>ISSN: 0306-4530</identifier><identifier>EISSN: 1873-3360</identifier><identifier>DOI: 10.1016/j.psyneuen.2005.04.003</identifier><identifier>PMID: 15949896</identifier><identifier>CODEN: PSYCDE</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Adult ; Awakening response ; Behavioral psychophysiology ; Biological and medical sciences ; Circadian rhythm ; Circadian Rhythm - genetics ; Circadian Rhythm - physiology ; Cortisol ; Female ; Fundamental and applied biological sciences. Psychology ; Heritability ; Hormones and behavior ; Humans ; Hydrocortisone - genetics ; Hydrocortisone - metabolism ; Male ; Models, Genetic ; Pedigree ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Reference Values ; Saliva - metabolism ; Siblings ; Twins ; Twins, Dizygotic ; Twins, Monozygotic</subject><ispartof>Psychoneuroendocrinology, 2005-10, Vol.30 (9), p.857-868</ispartof><rights>2005 Elsevier Ltd</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c444t-14afb7442fde6ed355b0be43805aff6f2fe9f7d641610e9dc3b06f4813c281b23</citedby><cites>FETCH-LOGICAL-c444t-14afb7442fde6ed355b0be43805aff6f2fe9f7d641610e9dc3b06f4813c281b23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.psyneuen.2005.04.003$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16972684$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15949896$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kupper, Nina</creatorcontrib><creatorcontrib>de Geus, Eco J.C.</creatorcontrib><creatorcontrib>van den Berg, Mireille</creatorcontrib><creatorcontrib>Kirschbaum, Clemens</creatorcontrib><creatorcontrib>Boomsma, Dorret I.</creatorcontrib><creatorcontrib>Willemsen, Gonneke</creatorcontrib><title>Familial influences on basal salivary cortisol in an adult population</title><title>Psychoneuroendocrinology</title><addtitle>Psychoneuroendocrinology</addtitle><description>To understand the underlying genetic and environmental sources of individual variation in basal cortisol levels, we collected salivary cortisol at awakening and at six fixed time points during the day in adult twins and their singleton siblings. Reported time of awakening was verified with heart rate and body movement recordings. Cortisol data were available for 199 MZ twins, 272 DZ twins and 229 singleton siblings from 309 twin families. No differences in cortisol means and variances were found between twins and singleton siblings. Additionally, the correlations for DZ twins and siblings were not significantly different, indicating generalizability of twin study results to the general population. Genetic model fitting showed heritability for cortisol levels during the awakening period (34% for cortisol level at awakening and 32% for cortisol level at 30
min after awakening) but not for cortisol levels later during the day. The current study shows that, while cortisol levels in the awakening period are influenced by genetic factors, cortisol levels throughout most of the day are not heritable, indicating that future gene finding studies for basal cortisol should focus on the first hour post-awakening.</description><subject>Adult</subject><subject>Awakening response</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Circadian rhythm</subject><subject>Circadian Rhythm - genetics</subject><subject>Circadian Rhythm - physiology</subject><subject>Cortisol</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Heritability</subject><subject>Hormones and behavior</subject><subject>Humans</subject><subject>Hydrocortisone - genetics</subject><subject>Hydrocortisone - metabolism</subject><subject>Male</subject><subject>Models, Genetic</subject><subject>Pedigree</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Reference Values</subject><subject>Saliva - metabolism</subject><subject>Siblings</subject><subject>Twins</subject><subject>Twins, Dizygotic</subject><subject>Twins, Monozygotic</subject><issn>0306-4530</issn><issn>1873-3360</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LxDAQhoMoun78BelFb62TJk3bmyK7Kghe9BzSdAJZsk1N2gX_vVl2ZY9CQmB43pnJQ8gthYICFQ_rYow_A844FCVAVQAvANgJWdCmZjljAk7JAhiInFcMLshljGsAEI0oz8kFrVreNq1YkOVKbayzymV2MC610xgzP2SdiqmWrt2q8JNpHyYb_Y7KVDr97KZs9OPs1GT9cE3OjHIRbw7vFflaLT-fX_P3j5e356f3XHPOp5xyZbqa89L0KLBnVdVBh5w1UCljhCkNtqbuBaeCAra9Zh0IwxvKdNnQrmRX5H7fdwz-e8Y4yY2NGp1TA_o5StFAyeu6TqDYgzr4GAMaOQa7ST-RFOROoFzLP4FyJ1ACl0lgCt4eJszdBvtj7GAsAXcHQEWtnAlq0DYeOdHWpWh44h73HCYfW4tBRm13ensbUE-y9_a_XX4BOP2TDw</recordid><startdate>20051001</startdate><enddate>20051001</enddate><creator>Kupper, Nina</creator><creator>de Geus, Eco J.C.</creator><creator>van den Berg, Mireille</creator><creator>Kirschbaum, Clemens</creator><creator>Boomsma, Dorret I.</creator><creator>Willemsen, Gonneke</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20051001</creationdate><title>Familial influences on basal salivary cortisol in an adult population</title><author>Kupper, Nina ; de Geus, Eco J.C. ; van den Berg, Mireille ; Kirschbaum, Clemens ; Boomsma, Dorret I. ; Willemsen, Gonneke</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c444t-14afb7442fde6ed355b0be43805aff6f2fe9f7d641610e9dc3b06f4813c281b23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Awakening response</topic><topic>Behavioral psychophysiology</topic><topic>Biological and medical sciences</topic><topic>Circadian rhythm</topic><topic>Circadian Rhythm - genetics</topic><topic>Circadian Rhythm - physiology</topic><topic>Cortisol</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Heritability</topic><topic>Hormones and behavior</topic><topic>Humans</topic><topic>Hydrocortisone - genetics</topic><topic>Hydrocortisone - metabolism</topic><topic>Male</topic><topic>Models, Genetic</topic><topic>Pedigree</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Reference Values</topic><topic>Saliva - metabolism</topic><topic>Siblings</topic><topic>Twins</topic><topic>Twins, Dizygotic</topic><topic>Twins, Monozygotic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kupper, Nina</creatorcontrib><creatorcontrib>de Geus, Eco J.C.</creatorcontrib><creatorcontrib>van den Berg, Mireille</creatorcontrib><creatorcontrib>Kirschbaum, Clemens</creatorcontrib><creatorcontrib>Boomsma, Dorret I.</creatorcontrib><creatorcontrib>Willemsen, Gonneke</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Psychoneuroendocrinology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kupper, Nina</au><au>de Geus, Eco J.C.</au><au>van den Berg, Mireille</au><au>Kirschbaum, Clemens</au><au>Boomsma, Dorret I.</au><au>Willemsen, Gonneke</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Familial influences on basal salivary cortisol in an adult population</atitle><jtitle>Psychoneuroendocrinology</jtitle><addtitle>Psychoneuroendocrinology</addtitle><date>2005-10-01</date><risdate>2005</risdate><volume>30</volume><issue>9</issue><spage>857</spage><epage>868</epage><pages>857-868</pages><issn>0306-4530</issn><eissn>1873-3360</eissn><coden>PSYCDE</coden><abstract>To understand the underlying genetic and environmental sources of individual variation in basal cortisol levels, we collected salivary cortisol at awakening and at six fixed time points during the day in adult twins and their singleton siblings. Reported time of awakening was verified with heart rate and body movement recordings. Cortisol data were available for 199 MZ twins, 272 DZ twins and 229 singleton siblings from 309 twin families. No differences in cortisol means and variances were found between twins and singleton siblings. Additionally, the correlations for DZ twins and siblings were not significantly different, indicating generalizability of twin study results to the general population. Genetic model fitting showed heritability for cortisol levels during the awakening period (34% for cortisol level at awakening and 32% for cortisol level at 30
min after awakening) but not for cortisol levels later during the day. The current study shows that, while cortisol levels in the awakening period are influenced by genetic factors, cortisol levels throughout most of the day are not heritable, indicating that future gene finding studies for basal cortisol should focus on the first hour post-awakening.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>15949896</pmid><doi>10.1016/j.psyneuen.2005.04.003</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Awakening response Behavioral psychophysiology Biological and medical sciences Circadian rhythm Circadian Rhythm - genetics Circadian Rhythm - physiology Cortisol Female Fundamental and applied biological sciences. Psychology Heritability Hormones and behavior Humans Hydrocortisone - genetics Hydrocortisone - metabolism Male Models, Genetic Pedigree Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Reference Values Saliva - metabolism Siblings Twins Twins, Dizygotic Twins, Monozygotic |
| title | Familial influences on basal salivary cortisol in an adult population |
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