dog as a sentinel for human infection: prevalence of Borrelia burgdorferi C6 antibodies in dogs from southeastern and mid-Atlantic states
Lyme disease is the most frequently reported human vector-associated disease in the United States. Infection occurs after the bite of an Ixodid tick that is infected with Borrelia burgdorferi . Dogs have often been reported to serve as effective sentinel animals to assess the risk of human B. burgdo...
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creator | Duncan, A.W Correa, M.T Levine, J.F Breitschwerdt, E.B |
description | Lyme disease is the most frequently reported human vector-associated disease in the United States. Infection occurs
after the bite of an Ixodid tick that is infected with
Borrelia burgdorferi
. Dogs have often been reported to
serve as effective sentinel animals to assess the risk of human
B. burgdorferi
infection. Based on published data
of human Lyme disease case numbers and our clinical impressions, we hypothesized that canine exposure to
B. burgdorferi
would be lower in North Carolina when compared to the exposure in Virginia, Maryland, and Pennsylvania.
To address this hypothesis, we evaluated
B. burgdorferi
exposure status utilizing a specific and sensitive
C6 peptide-based enzyme-linked immunosorbent assay. Our convenience sample included 1,666 canine serum
samples submitted to the Vector-Borne Disease Diagnostic Laboratory from North Carolina (
n
= 987), Virginia
(
n
= 472), Maryland (
n
= 167), and Pennsylvania (
n
= 40). Comparisons among states were made using the Chisquare
test or the Fisher's exact test;
p
-values were adjusted for multiple comparisons using the Bonferroni correction.
A Chi-square test for trend was used to determine if there was an increase in the frequency of seroreactors
associated with the geographical origin of the samples. The proportion of seroreactive dogs in North Carolina
was markedly lower (
p
< 0.008) than that observed in dogs from Virginia, Maryland, and Pennsylvania. These results
support the hypothesis that
B. burgdorferi
transmission seems to occur infrequently in North Carolina dogs
as compared to dogs residing in other southeastern and mid-Atlantic states. Furthermore, they support the utility
of dogs as a sentinel to characterize the risk of
B. burgdorferi
transmission to humans in a defined geographical
location.
Vector-Borne Zoonotic Dis. 5, 101-109. |
doi_str_mv | 10.1089/vbz.2005.5.101 |
format | Article |
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after the bite of an Ixodid tick that is infected with
Borrelia burgdorferi
. Dogs have often been reported to
serve as effective sentinel animals to assess the risk of human
B. burgdorferi
infection. Based on published data
of human Lyme disease case numbers and our clinical impressions, we hypothesized that canine exposure to
B. burgdorferi
would be lower in North Carolina when compared to the exposure in Virginia, Maryland, and Pennsylvania.
To address this hypothesis, we evaluated
B. burgdorferi
exposure status utilizing a specific and sensitive
C6 peptide-based enzyme-linked immunosorbent assay. Our convenience sample included 1,666 canine serum
samples submitted to the Vector-Borne Disease Diagnostic Laboratory from North Carolina (
n
= 987), Virginia
(
n
= 472), Maryland (
n
= 167), and Pennsylvania (
n
= 40). Comparisons among states were made using the Chisquare
test or the Fisher's exact test;
p
-values were adjusted for multiple comparisons using the Bonferroni correction.
A Chi-square test for trend was used to determine if there was an increase in the frequency of seroreactors
associated with the geographical origin of the samples. The proportion of seroreactive dogs in North Carolina
was markedly lower (
p
< 0.008) than that observed in dogs from Virginia, Maryland, and Pennsylvania. These results
support the hypothesis that
B. burgdorferi
transmission seems to occur infrequently in North Carolina dogs
as compared to dogs residing in other southeastern and mid-Atlantic states. Furthermore, they support the utility
of dogs as a sentinel to characterize the risk of
B. burgdorferi
transmission to humans in a defined geographical
location.
Vector-Borne Zoonotic Dis. 5, 101-109.</description><identifier>ISSN: 1530-3667</identifier><identifier>EISSN: 1557-7759</identifier><identifier>DOI: 10.1089/vbz.2005.5.101</identifier><identifier>PMID: 16011425</identifier><language>eng</language><publisher>United States: Mary Ann Liebert, Inc</publisher><subject>Animals ; Antibodies, Bacterial - blood ; antibody detection ; Arachnid Vectors - microbiology ; Borrelia burgdorferi ; Borrelia burgdorferi - immunology ; Carrier State - veterinary ; Disease Reservoirs - veterinary ; disease surveillance ; disease transmission ; Dog Diseases - epidemiology ; Dog Diseases - microbiology ; Dog Diseases - transmission ; Dogs ; enzyme-linked immunosorbent assay ; Enzyme-Linked Immunosorbent Assay - veterinary ; geographical variation ; Humans ; Ixodes - microbiology ; Ixodidae ; Lyme disease ; Lyme Disease - epidemiology ; Lyme Disease - microbiology ; Lyme Disease - transmission ; Maryland - epidemiology ; North Carolina - epidemiology ; Pennsylvania - epidemiology ; Research Papers ; risk assessment ; sentinel animals ; Sentinel Surveillance ; Seroepidemiologic Studies ; seroprevalence ; Virginia - epidemiology ; Zoonoses</subject><ispartof>Vector borne and zoonotic diseases (Larchmont, N.Y.), 2005-06, Vol.5 (2), p.101-109</ispartof><rights>2005, Mary Ann Liebert, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c385t-47c1b709f9550312a85bf5d0cb2e4be6f418b0231e604a3ea2451c9ceec672013</citedby><cites>FETCH-LOGICAL-c385t-47c1b709f9550312a85bf5d0cb2e4be6f418b0231e604a3ea2451c9ceec672013</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.liebertpub.com/doi/epdf/10.1089/vbz.2005.5.101$$EPDF$$P50$$Gmaryannliebert$$H</linktopdf><linktohtml>$$Uhttps://www.liebertpub.com/doi/full/10.1089/vbz.2005.5.101$$EHTML$$P50$$Gmaryannliebert$$H</linktohtml><link.rule.ids>315,781,785,3043,21725,27926,27927,55293,55305</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16011425$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Duncan, A.W</creatorcontrib><creatorcontrib>Correa, M.T</creatorcontrib><creatorcontrib>Levine, J.F</creatorcontrib><creatorcontrib>Breitschwerdt, E.B</creatorcontrib><title>dog as a sentinel for human infection: prevalence of Borrelia burgdorferi C6 antibodies in dogs from southeastern and mid-Atlantic states</title><title>Vector borne and zoonotic diseases (Larchmont, N.Y.)</title><addtitle>Vector Borne Zoonotic Dis</addtitle><description>Lyme disease is the most frequently reported human vector-associated disease in the United States. Infection occurs
after the bite of an Ixodid tick that is infected with
Borrelia burgdorferi
. Dogs have often been reported to
serve as effective sentinel animals to assess the risk of human
B. burgdorferi
infection. Based on published data
of human Lyme disease case numbers and our clinical impressions, we hypothesized that canine exposure to
B. burgdorferi
would be lower in North Carolina when compared to the exposure in Virginia, Maryland, and Pennsylvania.
To address this hypothesis, we evaluated
B. burgdorferi
exposure status utilizing a specific and sensitive
C6 peptide-based enzyme-linked immunosorbent assay. Our convenience sample included 1,666 canine serum
samples submitted to the Vector-Borne Disease Diagnostic Laboratory from North Carolina (
n
= 987), Virginia
(
n
= 472), Maryland (
n
= 167), and Pennsylvania (
n
= 40). Comparisons among states were made using the Chisquare
test or the Fisher's exact test;
p
-values were adjusted for multiple comparisons using the Bonferroni correction.
A Chi-square test for trend was used to determine if there was an increase in the frequency of seroreactors
associated with the geographical origin of the samples. The proportion of seroreactive dogs in North Carolina
was markedly lower (
p
< 0.008) than that observed in dogs from Virginia, Maryland, and Pennsylvania. These results
support the hypothesis that
B. burgdorferi
transmission seems to occur infrequently in North Carolina dogs
as compared to dogs residing in other southeastern and mid-Atlantic states. Furthermore, they support the utility
of dogs as a sentinel to characterize the risk of
B. burgdorferi
transmission to humans in a defined geographical
location.
Vector-Borne Zoonotic Dis. 5, 101-109.</description><subject>Animals</subject><subject>Antibodies, Bacterial - blood</subject><subject>antibody detection</subject><subject>Arachnid Vectors - microbiology</subject><subject>Borrelia burgdorferi</subject><subject>Borrelia burgdorferi - immunology</subject><subject>Carrier State - veterinary</subject><subject>Disease Reservoirs - veterinary</subject><subject>disease surveillance</subject><subject>disease transmission</subject><subject>Dog Diseases - epidemiology</subject><subject>Dog Diseases - microbiology</subject><subject>Dog Diseases - transmission</subject><subject>Dogs</subject><subject>enzyme-linked immunosorbent assay</subject><subject>Enzyme-Linked Immunosorbent Assay - veterinary</subject><subject>geographical variation</subject><subject>Humans</subject><subject>Ixodes - microbiology</subject><subject>Ixodidae</subject><subject>Lyme disease</subject><subject>Lyme Disease - epidemiology</subject><subject>Lyme Disease - microbiology</subject><subject>Lyme Disease - transmission</subject><subject>Maryland - epidemiology</subject><subject>North Carolina - epidemiology</subject><subject>Pennsylvania - epidemiology</subject><subject>Research Papers</subject><subject>risk assessment</subject><subject>sentinel animals</subject><subject>Sentinel Surveillance</subject><subject>Seroepidemiologic Studies</subject><subject>seroprevalence</subject><subject>Virginia - epidemiology</subject><subject>Zoonoses</subject><issn>1530-3667</issn><issn>1557-7759</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhiMEoh9w5Qg-cSLbsWM7Cbd2RQGpUg-lZ8t2xlujJF5spxL8A_51He0KDhw4eWb0-NGM3qp6Q2FDoesvHs2vDQMQG1F6-qw6pUK0dduK_vlaN1A3UrYn1VlK3wEY7ah4WZ1QCZRyJk6r30PYEZ2IJgnn7GcciQuRPCyTnomfHdrsw_yR7CM-6hFniyQ4chVixNFrYpa4G0J0GD3ZSqKLwoTBYyp_SVEn4mKYSApLfkCdMsa5QAOZ_FBf5nHlLUlZZ0yvqhdOjwlfH9_z6v7607ftl_rm9vPX7eVNbZtO5Jq3lpoWetcLAQ1luhPGiQGsYcgNSsdpZ4A1FCVw3aBmXFDbW0QrWwa0Oa_eH7z7GH4smLKafLI4lmUwLEnJDhiX0P4XpD3nvG9EATcH0MaQUkSn9tFPOv5UFNSakiopqTUlJUq_rvD2aF7MhMNf_BhLAT4cgHWs53n0aDDmP-A_vncH3Omg9C76pO7v1luBAuskh-YJAdCn-g</recordid><startdate>20050601</startdate><enddate>20050601</enddate><creator>Duncan, A.W</creator><creator>Correa, M.T</creator><creator>Levine, J.F</creator><creator>Breitschwerdt, E.B</creator><general>Mary Ann Liebert, Inc</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>8FD</scope><scope>C1K</scope><scope>F1W</scope><scope>FR3</scope><scope>H99</scope><scope>L.F</scope><scope>L.G</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20050601</creationdate><title>dog as a sentinel for human infection: prevalence of Borrelia burgdorferi C6 antibodies in dogs from southeastern and mid-Atlantic states</title><author>Duncan, A.W ; Correa, M.T ; Levine, J.F ; Breitschwerdt, E.B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c385t-47c1b709f9550312a85bf5d0cb2e4be6f418b0231e604a3ea2451c9ceec672013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Animals</topic><topic>Antibodies, Bacterial - blood</topic><topic>antibody detection</topic><topic>Arachnid Vectors - microbiology</topic><topic>Borrelia burgdorferi</topic><topic>Borrelia burgdorferi - immunology</topic><topic>Carrier State - veterinary</topic><topic>Disease Reservoirs - veterinary</topic><topic>disease surveillance</topic><topic>disease transmission</topic><topic>Dog Diseases - epidemiology</topic><topic>Dog Diseases - microbiology</topic><topic>Dog Diseases - transmission</topic><topic>Dogs</topic><topic>enzyme-linked immunosorbent assay</topic><topic>Enzyme-Linked Immunosorbent Assay - veterinary</topic><topic>geographical variation</topic><topic>Humans</topic><topic>Ixodes - microbiology</topic><topic>Ixodidae</topic><topic>Lyme disease</topic><topic>Lyme Disease - epidemiology</topic><topic>Lyme Disease - microbiology</topic><topic>Lyme Disease - transmission</topic><topic>Maryland - epidemiology</topic><topic>North Carolina - epidemiology</topic><topic>Pennsylvania - epidemiology</topic><topic>Research Papers</topic><topic>risk assessment</topic><topic>sentinel animals</topic><topic>Sentinel Surveillance</topic><topic>Seroepidemiologic Studies</topic><topic>seroprevalence</topic><topic>Virginia - epidemiology</topic><topic>Zoonoses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Duncan, A.W</creatorcontrib><creatorcontrib>Correa, M.T</creatorcontrib><creatorcontrib>Levine, J.F</creatorcontrib><creatorcontrib>Breitschwerdt, E.B</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Engineering Research Database</collection><collection>ASFA: Marine Biotechnology Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Marine Biotechnology Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Vector borne and zoonotic diseases (Larchmont, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Duncan, A.W</au><au>Correa, M.T</au><au>Levine, J.F</au><au>Breitschwerdt, E.B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>dog as a sentinel for human infection: prevalence of Borrelia burgdorferi C6 antibodies in dogs from southeastern and mid-Atlantic states</atitle><jtitle>Vector borne and zoonotic diseases (Larchmont, N.Y.)</jtitle><addtitle>Vector Borne Zoonotic Dis</addtitle><date>2005-06-01</date><risdate>2005</risdate><volume>5</volume><issue>2</issue><spage>101</spage><epage>109</epage><pages>101-109</pages><issn>1530-3667</issn><eissn>1557-7759</eissn><abstract>Lyme disease is the most frequently reported human vector-associated disease in the United States. Infection occurs
after the bite of an Ixodid tick that is infected with
Borrelia burgdorferi
. Dogs have often been reported to
serve as effective sentinel animals to assess the risk of human
B. burgdorferi
infection. Based on published data
of human Lyme disease case numbers and our clinical impressions, we hypothesized that canine exposure to
B. burgdorferi
would be lower in North Carolina when compared to the exposure in Virginia, Maryland, and Pennsylvania.
To address this hypothesis, we evaluated
B. burgdorferi
exposure status utilizing a specific and sensitive
C6 peptide-based enzyme-linked immunosorbent assay. Our convenience sample included 1,666 canine serum
samples submitted to the Vector-Borne Disease Diagnostic Laboratory from North Carolina (
n
= 987), Virginia
(
n
= 472), Maryland (
n
= 167), and Pennsylvania (
n
= 40). Comparisons among states were made using the Chisquare
test or the Fisher's exact test;
p
-values were adjusted for multiple comparisons using the Bonferroni correction.
A Chi-square test for trend was used to determine if there was an increase in the frequency of seroreactors
associated with the geographical origin of the samples. The proportion of seroreactive dogs in North Carolina
was markedly lower (
p
< 0.008) than that observed in dogs from Virginia, Maryland, and Pennsylvania. These results
support the hypothesis that
B. burgdorferi
transmission seems to occur infrequently in North Carolina dogs
as compared to dogs residing in other southeastern and mid-Atlantic states. Furthermore, they support the utility
of dogs as a sentinel to characterize the risk of
B. burgdorferi
transmission to humans in a defined geographical
location.
Vector-Borne Zoonotic Dis. 5, 101-109.</abstract><cop>United States</cop><pub>Mary Ann Liebert, Inc</pub><pmid>16011425</pmid><doi>10.1089/vbz.2005.5.101</doi><tpages>9</tpages></addata></record> |
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issn | 1530-3667 1557-7759 |
language | eng |
recordid | cdi_proquest_miscellaneous_68024607 |
source | Mary Ann Liebert Online Subscription; MEDLINE |
subjects | Animals Antibodies, Bacterial - blood antibody detection Arachnid Vectors - microbiology Borrelia burgdorferi Borrelia burgdorferi - immunology Carrier State - veterinary Disease Reservoirs - veterinary disease surveillance disease transmission Dog Diseases - epidemiology Dog Diseases - microbiology Dog Diseases - transmission Dogs enzyme-linked immunosorbent assay Enzyme-Linked Immunosorbent Assay - veterinary geographical variation Humans Ixodes - microbiology Ixodidae Lyme disease Lyme Disease - epidemiology Lyme Disease - microbiology Lyme Disease - transmission Maryland - epidemiology North Carolina - epidemiology Pennsylvania - epidemiology Research Papers risk assessment sentinel animals Sentinel Surveillance Seroepidemiologic Studies seroprevalence Virginia - epidemiology Zoonoses |
title | dog as a sentinel for human infection: prevalence of Borrelia burgdorferi C6 antibodies in dogs from southeastern and mid-Atlantic states |
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