Markers of endothelial damage in patients on hemodialysis and hemodiafiltration
The purpose of the study was to assess whether renal replacement therapy (RRT) in the form of hemodialysis (HD) or hemodiafiltration (HDF) affects hemostasis and endothelial function in patients with end-stage renal failure (ESRF). Thirty-five hemodialyzed patients and 14 HDF patients were evaluated...
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| Veröffentlicht in: | Journal of nephrology 2006-03, Vol.19 (2), p.150-154 |
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| container_title | Journal of nephrology |
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| creator | Małyszko, Jacek S Małyszko, Jolanta Hryszko, Tomasz Koźminski, Piotr Pawlak, Krystyna Mysliwiec, Michal |
| description | The purpose of the study was to assess whether renal replacement therapy (RRT) in the form of hemodialysis (HD) or hemodiafiltration (HDF) affects hemostasis and endothelial function in patients with end-stage renal failure (ESRF).
Thirty-five hemodialyzed patients and 14 HDF patients were evaluated regarding hemostatic parameters, serum lipids and endothelial cell injury markers.
HD patients did not differ significantly in regard to serum lipids, complete blood count, hemostasis, and dialysis adequacy as measured by Kt/V when compared to HDF patients. Only the markers of endothelial cell injury thrombomodulin and von Willebrand factor were significantly higher in HD when compared to HDF.
Patients on HD showed evidence of a higher degree of endothelial dysfunction than HDF patients. HDF seems to ameliorate endothelial dysfunction in comparison with HD. Therefore, hemostatic abnormalities in ESRF might be affected to some extent by the choice of RRT. |
| format | Article |
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Thirty-five hemodialyzed patients and 14 HDF patients were evaluated regarding hemostatic parameters, serum lipids and endothelial cell injury markers.
HD patients did not differ significantly in regard to serum lipids, complete blood count, hemostasis, and dialysis adequacy as measured by Kt/V when compared to HDF patients. Only the markers of endothelial cell injury thrombomodulin and von Willebrand factor were significantly higher in HD when compared to HDF.
Patients on HD showed evidence of a higher degree of endothelial dysfunction than HDF patients. HDF seems to ameliorate endothelial dysfunction in comparison with HD. Therefore, hemostatic abnormalities in ESRF might be affected to some extent by the choice of RRT.</description><identifier>ISSN: 1121-8428</identifier><identifier>PMID: 16736412</identifier><language>eng</language><publisher>Italy</publisher><subject>Adult ; Biomarkers - blood ; Endothelial Cells - metabolism ; Endothelium, Vascular - injuries ; Endothelium, Vascular - metabolism ; Female ; Hemodiafiltration - adverse effects ; Hemostasis ; Humans ; Kidney Failure, Chronic - blood ; Kidney Failure, Chronic - complications ; Male</subject><ispartof>Journal of nephrology, 2006-03, Vol.19 (2), p.150-154</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16736412$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Małyszko, Jacek S</creatorcontrib><creatorcontrib>Małyszko, Jolanta</creatorcontrib><creatorcontrib>Hryszko, Tomasz</creatorcontrib><creatorcontrib>Koźminski, Piotr</creatorcontrib><creatorcontrib>Pawlak, Krystyna</creatorcontrib><creatorcontrib>Mysliwiec, Michal</creatorcontrib><title>Markers of endothelial damage in patients on hemodialysis and hemodiafiltration</title><title>Journal of nephrology</title><addtitle>J Nephrol</addtitle><description>The purpose of the study was to assess whether renal replacement therapy (RRT) in the form of hemodialysis (HD) or hemodiafiltration (HDF) affects hemostasis and endothelial function in patients with end-stage renal failure (ESRF).
Thirty-five hemodialyzed patients and 14 HDF patients were evaluated regarding hemostatic parameters, serum lipids and endothelial cell injury markers.
HD patients did not differ significantly in regard to serum lipids, complete blood count, hemostasis, and dialysis adequacy as measured by Kt/V when compared to HDF patients. Only the markers of endothelial cell injury thrombomodulin and von Willebrand factor were significantly higher in HD when compared to HDF.
Patients on HD showed evidence of a higher degree of endothelial dysfunction than HDF patients. HDF seems to ameliorate endothelial dysfunction in comparison with HD. Therefore, hemostatic abnormalities in ESRF might be affected to some extent by the choice of RRT.</description><subject>Adult</subject><subject>Biomarkers - blood</subject><subject>Endothelial Cells - metabolism</subject><subject>Endothelium, Vascular - injuries</subject><subject>Endothelium, Vascular - metabolism</subject><subject>Female</subject><subject>Hemodiafiltration - adverse effects</subject><subject>Hemostasis</subject><subject>Humans</subject><subject>Kidney Failure, Chronic - blood</subject><subject>Kidney Failure, Chronic - complications</subject><subject>Male</subject><issn>1121-8428</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo10DtPwzAUBWAPIFoKfwF5YotkO3bijKjiJbXqAnPkxzU1OE6wnaH_nki005XO-XSGe4XWlDJaSc7kCt3m_E0IE4LxG7SiTVs3nLI1OuxV-oGU8egwRDuWIwSvArZqUF-AfcSTKh5iWUTERxhGu9Sn7DNW0V4C50NJixvjHbp2KmS4P98N-nx5_ti-VbvD6_v2aVdNjHSlMiC45GBawXRtnLTcOCe0kIy0zFrmoDFtB1oTC4wSTSkHZRptwIGlsq436PF_d0rj7wy59IPPBkJQEcY5940kjHPSLfDhDGc9gO2n5AeVTv3lBfUfX5tZFA</recordid><startdate>200603</startdate><enddate>200603</enddate><creator>Małyszko, Jacek S</creator><creator>Małyszko, Jolanta</creator><creator>Hryszko, Tomasz</creator><creator>Koźminski, Piotr</creator><creator>Pawlak, Krystyna</creator><creator>Mysliwiec, Michal</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200603</creationdate><title>Markers of endothelial damage in patients on hemodialysis and hemodiafiltration</title><author>Małyszko, Jacek S ; Małyszko, Jolanta ; Hryszko, Tomasz ; Koźminski, Piotr ; Pawlak, Krystyna ; Mysliwiec, Michal</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p209t-ce5484ec752b3cf8d4cff5b582072dd2fe6c79ebb0de210b114eac6bcefed1833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adult</topic><topic>Biomarkers - blood</topic><topic>Endothelial Cells - metabolism</topic><topic>Endothelium, Vascular - injuries</topic><topic>Endothelium, Vascular - metabolism</topic><topic>Female</topic><topic>Hemodiafiltration - adverse effects</topic><topic>Hemostasis</topic><topic>Humans</topic><topic>Kidney Failure, Chronic - blood</topic><topic>Kidney Failure, Chronic - complications</topic><topic>Male</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Małyszko, Jacek S</creatorcontrib><creatorcontrib>Małyszko, Jolanta</creatorcontrib><creatorcontrib>Hryszko, Tomasz</creatorcontrib><creatorcontrib>Koźminski, Piotr</creatorcontrib><creatorcontrib>Pawlak, Krystyna</creatorcontrib><creatorcontrib>Mysliwiec, Michal</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of nephrology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Małyszko, Jacek S</au><au>Małyszko, Jolanta</au><au>Hryszko, Tomasz</au><au>Koźminski, Piotr</au><au>Pawlak, Krystyna</au><au>Mysliwiec, Michal</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Markers of endothelial damage in patients on hemodialysis and hemodiafiltration</atitle><jtitle>Journal of nephrology</jtitle><addtitle>J Nephrol</addtitle><date>2006-03</date><risdate>2006</risdate><volume>19</volume><issue>2</issue><spage>150</spage><epage>154</epage><pages>150-154</pages><issn>1121-8428</issn><abstract>The purpose of the study was to assess whether renal replacement therapy (RRT) in the form of hemodialysis (HD) or hemodiafiltration (HDF) affects hemostasis and endothelial function in patients with end-stage renal failure (ESRF).
Thirty-five hemodialyzed patients and 14 HDF patients were evaluated regarding hemostatic parameters, serum lipids and endothelial cell injury markers.
HD patients did not differ significantly in regard to serum lipids, complete blood count, hemostasis, and dialysis adequacy as measured by Kt/V when compared to HDF patients. Only the markers of endothelial cell injury thrombomodulin and von Willebrand factor were significantly higher in HD when compared to HDF.
Patients on HD showed evidence of a higher degree of endothelial dysfunction than HDF patients. HDF seems to ameliorate endothelial dysfunction in comparison with HD. Therefore, hemostatic abnormalities in ESRF might be affected to some extent by the choice of RRT.</abstract><cop>Italy</cop><pmid>16736412</pmid><tpages>5</tpages></addata></record> |
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| ispartof | Journal of nephrology, 2006-03, Vol.19 (2), p.150-154 |
| issn | 1121-8428 |
| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adult Biomarkers - blood Endothelial Cells - metabolism Endothelium, Vascular - injuries Endothelium, Vascular - metabolism Female Hemodiafiltration - adverse effects Hemostasis Humans Kidney Failure, Chronic - blood Kidney Failure, Chronic - complications Male |
| title | Markers of endothelial damage in patients on hemodialysis and hemodiafiltration |
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