Examination of the impact of a range of Pluronic surfactants on the in-vitro solubilisation behaviour and oral bioavailability of lipidic formulations of atovaquone

Exogenous surfactants are increasingly used to enhance the dispersion properties of lipid‐based formulations of poorly water‐soluble drugs, yet their possible effects on formulation digestion and oral bioavailability in‐vivo are not well documented. In this study, in‐vitro dispersion and digestion e...

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Veröffentlicht in:Journal of pharmacy and pharmacology 2006-06, Vol.58 (6), p.809-820
Hauptverfasser: Sek, Leab, Boyd, Ben J., Charman, William N., Porter, Christopher J. H.
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Sprache:eng
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