In vitro phototoxicity of 5-aminolevulinic acid and its methyl ester and the influence of barrier properties on their release from a bioadhesive patch

Topical administration of excess exogenous 5-aminolevulinic acid (ALA) leads to selective accumulation of the potent photosensitiser protoporphyrin IX (PpIX) in neoplastic cells, which can then be destroyed by irradiation with visible light. Due to its hydrophilicity, ALA penetrates deep lesions, su...

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Veröffentlicht in:	European journal of pharmaceutics and biopharmaceutics 2006-07, Vol.63 (3), p.295-309
Hauptverfasser:	Gilmore, Brendan F., McCarron, Paul A., Morrow, Desmond I.J., Murphy, Diarmaid J., Woolfson, A. David, Donnelly, Ryan F.
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Aminolevulinic acid Aminolevulinic Acid - administration & dosage Aminolevulinic Acid - pharmacokinetics Bioadhesion Biological and medical sciences Cell Line, Tumor Chemistry, Pharmaceutical Chromatography, High Pressure Liquid Drug delivery Drug Delivery Systems Epidermis - metabolism General pharmacology Humans Medical sciences Membranes, Artificial Ointments Patches Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Photochemotherapy - methods Photodynamic therapy Photosensitizing Agents - administration & dosage Protoporphyrins - biosynthesis Skin Neoplasms - drug therapy Stratum corneum
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