Astrocytic Ca2+ signaling evoked by sensory stimulation in vivo

Although astrocytes are the most abundant cell type in the brain, evidence for their activation during physiological sensory activity is lacking. Here we show that whisker stimulation evokes increases in astrocytic cytosolic calcium (Ca 2+ ) within the barrel cortex of adult mice. Increases in astro...

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Veröffentlicht in:	Nature neuroscience 2006-06, Vol.9 (6), p.816-823
Hauptverfasser:	Wang, Xiaohai, Lou, Nanhong, Xu, Qiwu, Tian, Guo-Feng, Peng, Wei Guo, Han, Xiaoning, Kang, Jian, Takano, Takahiro, Nedergaard, Maiken
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Afferent Pathways - physiology Animal Genetics and Genomics Animals Astrocytes Astrocytes - drug effects Astrocytes - metabolism Behavioral Sciences Biological Techniques Biomedical and Life Sciences Biomedicine Calcium - metabolism Calcium Signaling - drug effects Calcium Signaling - physiology Cell Communication - drug effects Cell Communication - physiology Central nervous system Electrodes Excitatory Amino Acid Antagonists - pharmacology Excitatory Postsynaptic Potentials - drug effects Excitatory Postsynaptic Potentials - physiology Female Male Mechanoreceptors - physiology Mice Neural transmission Neurobiology Neurosciences Physical Stimulation Physiology Reaction Time - drug effects Reaction Time - physiology Receptors, AMPA - antagonists & inhibitors Receptors, AMPA - metabolism Receptors, Metabotropic Glutamate - agonists Receptors, Metabotropic Glutamate - metabolism Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Receptors, N-Methyl-D-Aspartate - metabolism Regulation Somatosensory Cortex - cytology Somatosensory Cortex - physiology Synaptic Transmission - drug effects Synaptic Transmission - physiology Touch - physiology Up-Regulation - drug effects Up-Regulation - physiology Vibrissae - innervation Vibrissae - physiology
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