Astrocytic Ca2+ signaling evoked by sensory stimulation in vivo
Although astrocytes are the most abundant cell type in the brain, evidence for their activation during physiological sensory activity is lacking. Here we show that whisker stimulation evokes increases in astrocytic cytosolic calcium (Ca 2+ ) within the barrel cortex of adult mice. Increases in astro...
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| Veröffentlicht in: | Nature neuroscience 2006-06, Vol.9 (6), p.816-823 |
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| creator | Wang, Xiaohai Lou, Nanhong Xu, Qiwu Tian, Guo-Feng Peng, Wei Guo Han, Xiaoning Kang, Jian Takano, Takahiro Nedergaard, Maiken |
| description | Although astrocytes are the most abundant cell type in the brain, evidence for their activation during physiological sensory activity is lacking. Here we show that whisker stimulation evokes increases in astrocytic cytosolic calcium (Ca
2+
) within the barrel cortex of adult mice. Increases in astrocytic Ca
2+
were a function of the frequency of stimulation, occurred within several seconds and were inhibited by metabotropic glutamate receptor antagonists. To distinguish between synaptic input and output, local synaptic activity in cortical layer 2 was silenced by iontophoresis of AMPA and NMDA receptor antagonists. The antagonists did not reduce astrocytic Ca
2+
responses despite a marked reduction in excitatory postsynaptic currents in response to whisker stimulation. These findings indicate that astrocytes respond to synaptic input, by means of spillover or ectopic release of glutamate, and that increases in astrocytic Ca
2+
occur independently of postsynaptic excitatory activity. |
| doi_str_mv | 10.1038/nn1703 |
| format | Article |
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2+
) within the barrel cortex of adult mice. Increases in astrocytic Ca
2+
were a function of the frequency of stimulation, occurred within several seconds and were inhibited by metabotropic glutamate receptor antagonists. To distinguish between synaptic input and output, local synaptic activity in cortical layer 2 was silenced by iontophoresis of AMPA and NMDA receptor antagonists. The antagonists did not reduce astrocytic Ca
2+
responses despite a marked reduction in excitatory postsynaptic currents in response to whisker stimulation. These findings indicate that astrocytes respond to synaptic input, by means of spillover or ectopic release of glutamate, and that increases in astrocytic Ca
2+
occur independently of postsynaptic excitatory activity.</description><identifier>ISSN: 1097-6256</identifier><identifier>EISSN: 1546-1726</identifier><identifier>DOI: 10.1038/nn1703</identifier><identifier>PMID: 16699507</identifier><identifier>CODEN: NANEFN</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>Adenosine ; Afferent Pathways - physiology ; Animal Genetics and Genomics ; Animals ; Astrocytes ; Astrocytes - drug effects ; Astrocytes - metabolism ; Behavioral Sciences ; Biological Techniques ; Biomedical and Life Sciences ; Biomedicine ; Calcium - metabolism ; Calcium Signaling - drug effects ; Calcium Signaling - physiology ; Cell Communication - drug effects ; Cell Communication - physiology ; Central nervous system ; Electrodes ; Excitatory Amino Acid Antagonists - pharmacology ; Excitatory Postsynaptic Potentials - drug effects ; Excitatory Postsynaptic Potentials - physiology ; Female ; Male ; Mechanoreceptors - physiology ; Mice ; Neural transmission ; Neurobiology ; Neurosciences ; Physical Stimulation ; Physiology ; Reaction Time - drug effects ; Reaction Time - physiology ; Receptors, AMPA - antagonists & inhibitors ; Receptors, AMPA - metabolism ; Receptors, Metabotropic Glutamate - agonists ; Receptors, Metabotropic Glutamate - metabolism ; Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors ; Receptors, N-Methyl-D-Aspartate - metabolism ; Regulation ; Somatosensory Cortex - cytology ; Somatosensory Cortex - physiology ; Synaptic Transmission - drug effects ; Synaptic Transmission - physiology ; Touch - physiology ; Up-Regulation - drug effects ; Up-Regulation - physiology ; Vibrissae - innervation ; Vibrissae - physiology</subject><ispartof>Nature neuroscience, 2006-06, Vol.9 (6), p.816-823</ispartof><rights>Springer Nature America, Inc. 2006</rights><rights>COPYRIGHT 2006 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Jun 2006</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c339t-8093636e01c1da270f3809634934437ebf583b3043a1a16a919c9a89d22f7a513</citedby><cites>FETCH-LOGICAL-c339t-8093636e01c1da270f3809634934437ebf583b3043a1a16a919c9a89d22f7a513</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/nn1703$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/nn1703$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16699507$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Xiaohai</creatorcontrib><creatorcontrib>Lou, Nanhong</creatorcontrib><creatorcontrib>Xu, Qiwu</creatorcontrib><creatorcontrib>Tian, Guo-Feng</creatorcontrib><creatorcontrib>Peng, Wei Guo</creatorcontrib><creatorcontrib>Han, Xiaoning</creatorcontrib><creatorcontrib>Kang, Jian</creatorcontrib><creatorcontrib>Takano, Takahiro</creatorcontrib><creatorcontrib>Nedergaard, Maiken</creatorcontrib><title>Astrocytic Ca2+ signaling evoked by sensory stimulation in vivo</title><title>Nature neuroscience</title><addtitle>Nat Neurosci</addtitle><addtitle>Nat Neurosci</addtitle><description>Although astrocytes are the most abundant cell type in the brain, evidence for their activation during physiological sensory activity is lacking. Here we show that whisker stimulation evokes increases in astrocytic cytosolic calcium (Ca
2+
) within the barrel cortex of adult mice. Increases in astrocytic Ca
2+
were a function of the frequency of stimulation, occurred within several seconds and were inhibited by metabotropic glutamate receptor antagonists. To distinguish between synaptic input and output, local synaptic activity in cortical layer 2 was silenced by iontophoresis of AMPA and NMDA receptor antagonists. The antagonists did not reduce astrocytic Ca
2+
responses despite a marked reduction in excitatory postsynaptic currents in response to whisker stimulation. These findings indicate that astrocytes respond to synaptic input, by means of spillover or ectopic release of glutamate, and that increases in astrocytic Ca
2+
occur independently of postsynaptic excitatory activity.</description><subject>Adenosine</subject><subject>Afferent Pathways - physiology</subject><subject>Animal Genetics and Genomics</subject><subject>Animals</subject><subject>Astrocytes</subject><subject>Astrocytes - drug effects</subject><subject>Astrocytes - metabolism</subject><subject>Behavioral Sciences</subject><subject>Biological Techniques</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Calcium - metabolism</subject><subject>Calcium Signaling - drug effects</subject><subject>Calcium Signaling - physiology</subject><subject>Cell Communication - drug effects</subject><subject>Cell Communication - physiology</subject><subject>Central nervous system</subject><subject>Electrodes</subject><subject>Excitatory Amino Acid Antagonists - pharmacology</subject><subject>Excitatory Postsynaptic Potentials - drug effects</subject><subject>Excitatory Postsynaptic Potentials - physiology</subject><subject>Female</subject><subject>Male</subject><subject>Mechanoreceptors - physiology</subject><subject>Mice</subject><subject>Neural transmission</subject><subject>Neurobiology</subject><subject>Neurosciences</subject><subject>Physical Stimulation</subject><subject>Physiology</subject><subject>Reaction Time - drug effects</subject><subject>Reaction Time - physiology</subject><subject>Receptors, AMPA - antagonists & inhibitors</subject><subject>Receptors, AMPA - metabolism</subject><subject>Receptors, Metabotropic Glutamate - agonists</subject><subject>Receptors, Metabotropic Glutamate - metabolism</subject><subject>Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors</subject><subject>Receptors, N-Methyl-D-Aspartate - metabolism</subject><subject>Regulation</subject><subject>Somatosensory Cortex - cytology</subject><subject>Somatosensory Cortex - physiology</subject><subject>Synaptic Transmission - drug effects</subject><subject>Synaptic Transmission - physiology</subject><subject>Touch - physiology</subject><subject>Up-Regulation - drug effects</subject><subject>Up-Regulation - physiology</subject><subject>Vibrissae - innervation</subject><subject>Vibrissae - physiology</subject><issn>1097-6256</issn><issn>1546-1726</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpdkdtKxDAQhoMoHlZ9BCleKCLVHJqkuZJl8QSC4OE6ZNO0RNtEk3Rx397ILogyFzPMfPMzww_AIYIXCJL60jnEIdkAu4hWrEQcs81cQ8FLhinbAXsxvkEIOa3FNthBjAlBId8FV9OYgtfLZHUxU_i8iLZzqreuK8zCv5ummC-LaFz0Iedkh7FXyXpXWFcs7MLvg61W9dEcrPMEvN5cv8zuyofH2_vZ9KHUhIhU1lAQRpiBSKNGYQ5bkluMVIJUFeFm3tKazAmsiEIKMSWQ0ELVosG45YoiMgEnK92P4D9HE5McbNSm75UzfoyS1RBjmkUm4Pgf-ObHkF-KEvOKIUY5y9DFCupUb6R1rU9B6RyNGaz2zrQ296eoppSwWoi8cPZnITPJfKVOjTHK--env-z6VB18jMG08iPYQYWlRFD-mCVXZmXwaH3qOB9M84ut3cnA6QqIeeQ6E35_-Sf1DaFKl_0</recordid><startdate>20060601</startdate><enddate>20060601</enddate><creator>Wang, Xiaohai</creator><creator>Lou, Nanhong</creator><creator>Xu, Qiwu</creator><creator>Tian, Guo-Feng</creator><creator>Peng, Wei Guo</creator><creator>Han, Xiaoning</creator><creator>Kang, Jian</creator><creator>Takano, Takahiro</creator><creator>Nedergaard, Maiken</creator><general>Nature Publishing Group US</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TM</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20060601</creationdate><title>Astrocytic Ca2+ signaling evoked by sensory stimulation in vivo</title><author>Wang, Xiaohai ; Lou, Nanhong ; Xu, Qiwu ; Tian, Guo-Feng ; Peng, Wei Guo ; Han, Xiaoning ; Kang, Jian ; Takano, Takahiro ; Nedergaard, Maiken</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c339t-8093636e01c1da270f3809634934437ebf583b3043a1a16a919c9a89d22f7a513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adenosine</topic><topic>Afferent Pathways - physiology</topic><topic>Animal Genetics and Genomics</topic><topic>Animals</topic><topic>Astrocytes</topic><topic>Astrocytes - drug effects</topic><topic>Astrocytes - metabolism</topic><topic>Behavioral Sciences</topic><topic>Biological Techniques</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Calcium - metabolism</topic><topic>Calcium Signaling - drug effects</topic><topic>Calcium Signaling - physiology</topic><topic>Cell Communication - drug effects</topic><topic>Cell Communication - physiology</topic><topic>Central nervous system</topic><topic>Electrodes</topic><topic>Excitatory Amino Acid Antagonists - pharmacology</topic><topic>Excitatory Postsynaptic Potentials - drug effects</topic><topic>Excitatory Postsynaptic Potentials - physiology</topic><topic>Female</topic><topic>Male</topic><topic>Mechanoreceptors - physiology</topic><topic>Mice</topic><topic>Neural transmission</topic><topic>Neurobiology</topic><topic>Neurosciences</topic><topic>Physical Stimulation</topic><topic>Physiology</topic><topic>Reaction Time - 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Academic</collection><jtitle>Nature neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Xiaohai</au><au>Lou, Nanhong</au><au>Xu, Qiwu</au><au>Tian, Guo-Feng</au><au>Peng, Wei Guo</au><au>Han, Xiaoning</au><au>Kang, Jian</au><au>Takano, Takahiro</au><au>Nedergaard, Maiken</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Astrocytic Ca2+ signaling evoked by sensory stimulation in vivo</atitle><jtitle>Nature neuroscience</jtitle><stitle>Nat Neurosci</stitle><addtitle>Nat Neurosci</addtitle><date>2006-06-01</date><risdate>2006</risdate><volume>9</volume><issue>6</issue><spage>816</spage><epage>823</epage><pages>816-823</pages><issn>1097-6256</issn><eissn>1546-1726</eissn><coden>NANEFN</coden><abstract>Although astrocytes are the most abundant cell type in the brain, evidence for their activation during physiological sensory activity is lacking. Here we show that whisker stimulation evokes increases in astrocytic cytosolic calcium (Ca
2+
) within the barrel cortex of adult mice. Increases in astrocytic Ca
2+
were a function of the frequency of stimulation, occurred within several seconds and were inhibited by metabotropic glutamate receptor antagonists. To distinguish between synaptic input and output, local synaptic activity in cortical layer 2 was silenced by iontophoresis of AMPA and NMDA receptor antagonists. The antagonists did not reduce astrocytic Ca
2+
responses despite a marked reduction in excitatory postsynaptic currents in response to whisker stimulation. These findings indicate that astrocytes respond to synaptic input, by means of spillover or ectopic release of glutamate, and that increases in astrocytic Ca
2+
occur independently of postsynaptic excitatory activity.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>16699507</pmid><doi>10.1038/nn1703</doi><tpages>8</tpages></addata></record> |
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| ispartof | Nature neuroscience, 2006-06, Vol.9 (6), p.816-823 |
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| source | MEDLINE; Springer Nature - Complete Springer Journals; Nature Journals Online |
| subjects | Adenosine Afferent Pathways - physiology Animal Genetics and Genomics Animals Astrocytes Astrocytes - drug effects Astrocytes - metabolism Behavioral Sciences Biological Techniques Biomedical and Life Sciences Biomedicine Calcium - metabolism Calcium Signaling - drug effects Calcium Signaling - physiology Cell Communication - drug effects Cell Communication - physiology Central nervous system Electrodes Excitatory Amino Acid Antagonists - pharmacology Excitatory Postsynaptic Potentials - drug effects Excitatory Postsynaptic Potentials - physiology Female Male Mechanoreceptors - physiology Mice Neural transmission Neurobiology Neurosciences Physical Stimulation Physiology Reaction Time - drug effects Reaction Time - physiology Receptors, AMPA - antagonists & inhibitors Receptors, AMPA - metabolism Receptors, Metabotropic Glutamate - agonists Receptors, Metabotropic Glutamate - metabolism Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Receptors, N-Methyl-D-Aspartate - metabolism Regulation Somatosensory Cortex - cytology Somatosensory Cortex - physiology Synaptic Transmission - drug effects Synaptic Transmission - physiology Touch - physiology Up-Regulation - drug effects Up-Regulation - physiology Vibrissae - innervation Vibrissae - physiology |
| title | Astrocytic Ca2+ signaling evoked by sensory stimulation in vivo |
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