P2X(7) receptor-mRNA and -protein in the mouse retina; changes during retinal degeneration in BALBCrds mice

A combined real-time PCR/immunohistochemistry study was carried out to investigate whether P2X(7) receptors, known to induce apoptosis and necrosis, may be causally related to the process of retinal degeneration in BALBCrds mice. In the retinae of BALBCrds mice, P2X(7) receptor-mRNA was the highest...

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Veröffentlicht in:	Neurochemistry international 2005-09, Vol.47 (4), p.235-242
Hauptverfasser:	Franke, Heike, Klimke, Kerstin, Brinckmann, Ute, Grosche, Jens, Francke, Mike, Sperlagh, Beata, Reichenbach, Andreas, Liebert, Uwe Gerd, Illes, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - metabolism Animals Biomarkers - metabolism Disease Models, Animal Down-Regulation - physiology Female Male Mice Mice, Inbred BALB C Mice, Neurologic Mutants Microtubule-Associated Proteins - metabolism Nerve Degeneration - genetics Nerve Degeneration - metabolism Nerve Degeneration - physiopathology Nerve Tissue Proteins - metabolism Neuroglia - metabolism Neuroglia - pathology Nuclear Proteins - metabolism Receptors, Purinergic P2 - genetics Receptors, Purinergic P2 - metabolism Receptors, Purinergic P2X7 Retina - metabolism Retina - pathology Retina - physiopathology Retinal Degeneration - genetics Retinal Degeneration - metabolism Retinal Degeneration - physiopathology Retinal Ganglion Cells - metabolism Retinal Ganglion Cells - pathology RNA, Messenger - metabolism Up-Regulation - physiology
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