Germline mutations of the hMLH1 and hMSH2 mismatch repair genes in Belgian hereditary nonpolyposis colon cancer (HNPCC) patients

Hereditary nonpolyposis colon cancer (HNPCC-Lynch syndrome) is caused by mutations in genes involved in DNA mismatch repair (MMR), mostly in the hMLH1 and hMSH2 genes. The mutation spectrum in the Belgian population is still poorly documented. To report our experience on the mutation screening in Be...

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Veröffentlicht in:	Familial cancer 2006-06, Vol.5 (2), p.179-189
Hauptverfasser:	Spaepen, M, Vankeirsbilck, B, Van Opstal, S, Tejpar, S, Van Cutsem, E, Geboes, K, Legius, E, Matthijs, G
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Base Pair Mismatch - genetics Carrier Proteins - genetics Codon, Nonsense Colorectal Neoplasms, Hereditary Nonpolyposis - genetics DNA Repair - genetics Frameshift Mutation Gene Deletion Germ-Line Mutation Humans Microsatellite Repeats Mutation, Missense MutL Protein Homolog 1 MutS Homolog 2 Protein - genetics Nuclear Proteins - genetics
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