New mechanisms of skin innate immunity: ASK1‐mediated keratinocyte differentiation regulates the expression of β‐defensins, LL37, and TLR2

Epidermal keratinocytes differentiate and form a multilayered epidermis, which is the primary barrier between the body and the outer environment. As the epidermis is constantly exposed to a variety of microbial pathogens, its function of resisting microbial pathogens is vital. This characteristic fe...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	European journal of immunology 2005-06, Vol.35 (6), p.1886-1895
Hauptverfasser:	Sayama, Koji, Komatsuzawa, Hitoshi, Yamasaki, Kenshi, Shirakata, Yuji, Hanakawa, Yasushi, Ouhara, Kazuhisa, Tokumaru, Sho, Dai, Xiuju, Tohyama, Mikiko, ten Dijke, Peter, Sugai, Motoyuki, Ichijo, Hidenori, Hashimoto, Koji
Format:	Artikel
Sprache:	eng
Schlagworte:	Antimicrobial Cationic Peptides - analysis Antimicrobial Cationic Peptides - genetics ASK1 beta-Defensins - analysis beta-Defensins - genetics Cathelicidins Cell Differentiation Gene Expression Regulation Humans Imidazoles - pharmacology Immunity, Innate Keratinocyte Keratinocytes - chemistry Keratinocytes - cytology LL37 MAP Kinase Kinase Kinase 5 - physiology Membrane Glycoproteins - analysis Membrane Glycoproteins - genetics p38 Mitogen-Activated Protein Kinases - physiology Pyridines - pharmacology Receptors, Cell Surface - analysis Receptors, Cell Surface - genetics RNA, Messenger - analysis Skin - immunology Staphylococcus aureus - immunology TLR2 Toll-Like Receptor 2 Toll-Like Receptors β‐defensins
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!