Results of an interlaboratory test on antimicrobial susceptibility testing of bacteria from animals by broth microdilution
A standard operating procedure for the determination of minimum inhibitory concentrations (MICs) of antimicrobial agents by the broth microdilution method was developed and evaluated for its fitness for use in an interlaboratory ring trial involving 46 routine diagnostic laboratories. All laboratori...
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| Veröffentlicht in: | International journal of antimicrobial agents 2006-06, Vol.27 (6), p.482-490 |
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| creator | Wallmann, Jürgen Böttner, Alexander Goossens, Luc Hafez, H. Mohamed Hartmann, Katrin Kaspar, Heike Kehrenberg, Corinna Kietzmann, Manfred Klarmann, Dieter Klein, Günter Krabisch, Peter Kühn, Tilman Luhofer, Gabriele Richter, Angelika Schulz, Bianka Schwarz, Stefan Sigge, Claudia Traeder, Wolfgang Waldmann, Karl-Heinz Werckenthin, Christiane Zschiesche, Eva |
| description | A standard operating procedure for the determination of minimum inhibitory concentrations (MICs) of antimicrobial agents by the broth microdilution method was developed and evaluated for its fitness for use in an interlaboratory ring trial involving 46 routine diagnostic laboratories. All laboratories tested five strains (one reference strain and four field strains) against a total of 22 different antimicrobial agents. Gram-negative strains were tested against 16 different antimicrobial agents and Gram-positive strains against 14 different antimicrobial agents. Tests were performed once a week for three consecutive weeks. At least 80% of the results determined by 35 of the 46 participating laboratories were within the expected range (mode MIC
±
1 dilution step), with the 18 participating laboratories experienced in MIC determination showing a slightly higher mean percentage of accurate results (89.3% reproducible results) than the 28 non-experienced laboratories (86.7% reproducible results). The most accurate results were obtained for the
Escherichia coli field strain, whilst the results for the
Streptococcus uberis field strain showed the highest error rate. Among the 22 antimicrobial agents tested, the highest variabilities in the results (mean value for all antimicrobial agents 12.3%) were recorded for ceftiofur (27.8%), penicillin G (20.8%) and cefoperazone (20.6%). |
| doi_str_mv | 10.1016/j.ijantimicag.2005.12.011 |
| format | Article |
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±
1 dilution step), with the 18 participating laboratories experienced in MIC determination showing a slightly higher mean percentage of accurate results (89.3% reproducible results) than the 28 non-experienced laboratories (86.7% reproducible results). The most accurate results were obtained for the
Escherichia coli field strain, whilst the results for the
Streptococcus uberis field strain showed the highest error rate. Among the 22 antimicrobial agents tested, the highest variabilities in the results (mean value for all antimicrobial agents 12.3%) were recorded for ceftiofur (27.8%), penicillin G (20.8%) and cefoperazone (20.6%).</description><identifier>ISSN: 0924-8579</identifier><identifier>EISSN: 1872-7913</identifier><identifier>DOI: 10.1016/j.ijantimicag.2005.12.011</identifier><identifier>PMID: 16697559</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>Animals ; Anti-Bacterial Agents - pharmacology ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antimicrobial agents ; Bacteria - drug effects ; Biological and medical sciences ; Broth microdilution ; Clinical Laboratory Techniques ; Escherichia coli ; Interlaboratory test ; Medical sciences ; Microbial Sensitivity Tests - methods ; Minimum inhibitory concentration ; Pharmacology. Drug treatments ; Streptococcus uberis ; Susceptibility testing</subject><ispartof>International journal of antimicrobial agents, 2006-06, Vol.27 (6), p.482-490</ispartof><rights>2006 Elsevier B.V. and the International Society of Chemotherapy</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c436t-795313d32cb25979a814cfc30781e99c6f82afd7c42453edc605c9187d29c3e13</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ijantimicag.2005.12.011$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17825780$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16697559$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wallmann, Jürgen</creatorcontrib><creatorcontrib>Böttner, Alexander</creatorcontrib><creatorcontrib>Goossens, Luc</creatorcontrib><creatorcontrib>Hafez, H. Mohamed</creatorcontrib><creatorcontrib>Hartmann, Katrin</creatorcontrib><creatorcontrib>Kaspar, Heike</creatorcontrib><creatorcontrib>Kehrenberg, Corinna</creatorcontrib><creatorcontrib>Kietzmann, Manfred</creatorcontrib><creatorcontrib>Klarmann, Dieter</creatorcontrib><creatorcontrib>Klein, Günter</creatorcontrib><creatorcontrib>Krabisch, Peter</creatorcontrib><creatorcontrib>Kühn, Tilman</creatorcontrib><creatorcontrib>Luhofer, Gabriele</creatorcontrib><creatorcontrib>Richter, Angelika</creatorcontrib><creatorcontrib>Schulz, Bianka</creatorcontrib><creatorcontrib>Schwarz, Stefan</creatorcontrib><creatorcontrib>Sigge, Claudia</creatorcontrib><creatorcontrib>Traeder, Wolfgang</creatorcontrib><creatorcontrib>Waldmann, Karl-Heinz</creatorcontrib><creatorcontrib>Werckenthin, Christiane</creatorcontrib><creatorcontrib>Zschiesche, Eva</creatorcontrib><creatorcontrib>for the Working Group ‘Antimicrobial Resistance’ of the German Veterinary Society</creatorcontrib><creatorcontrib>Working Group Antimicrobial Resistance of the German Veterinary Society</creatorcontrib><title>Results of an interlaboratory test on antimicrobial susceptibility testing of bacteria from animals by broth microdilution</title><title>International journal of antimicrobial agents</title><addtitle>Int J Antimicrob Agents</addtitle><description>A standard operating procedure for the determination of minimum inhibitory concentrations (MICs) of antimicrobial agents by the broth microdilution method was developed and evaluated for its fitness for use in an interlaboratory ring trial involving 46 routine diagnostic laboratories. All laboratories tested five strains (one reference strain and four field strains) against a total of 22 different antimicrobial agents. Gram-negative strains were tested against 16 different antimicrobial agents and Gram-positive strains against 14 different antimicrobial agents. Tests were performed once a week for three consecutive weeks. At least 80% of the results determined by 35 of the 46 participating laboratories were within the expected range (mode MIC
±
1 dilution step), with the 18 participating laboratories experienced in MIC determination showing a slightly higher mean percentage of accurate results (89.3% reproducible results) than the 28 non-experienced laboratories (86.7% reproducible results). The most accurate results were obtained for the
Escherichia coli field strain, whilst the results for the
Streptococcus uberis field strain showed the highest error rate. Among the 22 antimicrobial agents tested, the highest variabilities in the results (mean value for all antimicrobial agents 12.3%) were recorded for ceftiofur (27.8%), penicillin G (20.8%) and cefoperazone (20.6%).</description><subject>Animals</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antimicrobial agents</subject><subject>Bacteria - drug effects</subject><subject>Biological and medical sciences</subject><subject>Broth microdilution</subject><subject>Clinical Laboratory Techniques</subject><subject>Escherichia coli</subject><subject>Interlaboratory test</subject><subject>Medical sciences</subject><subject>Microbial Sensitivity Tests - methods</subject><subject>Minimum inhibitory concentration</subject><subject>Pharmacology. 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Mohamed</au><au>Hartmann, Katrin</au><au>Kaspar, Heike</au><au>Kehrenberg, Corinna</au><au>Kietzmann, Manfred</au><au>Klarmann, Dieter</au><au>Klein, Günter</au><au>Krabisch, Peter</au><au>Kühn, Tilman</au><au>Luhofer, Gabriele</au><au>Richter, Angelika</au><au>Schulz, Bianka</au><au>Schwarz, Stefan</au><au>Sigge, Claudia</au><au>Traeder, Wolfgang</au><au>Waldmann, Karl-Heinz</au><au>Werckenthin, Christiane</au><au>Zschiesche, Eva</au><aucorp>for the Working Group ‘Antimicrobial Resistance’ of the German Veterinary Society</aucorp><aucorp>Working Group Antimicrobial Resistance of the German Veterinary Society</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Results of an interlaboratory test on antimicrobial susceptibility testing of bacteria from animals by broth microdilution</atitle><jtitle>International journal of antimicrobial agents</jtitle><addtitle>Int J Antimicrob Agents</addtitle><date>2006-06-01</date><risdate>2006</risdate><volume>27</volume><issue>6</issue><spage>482</spage><epage>490</epage><pages>482-490</pages><issn>0924-8579</issn><eissn>1872-7913</eissn><abstract>A standard operating procedure for the determination of minimum inhibitory concentrations (MICs) of antimicrobial agents by the broth microdilution method was developed and evaluated for its fitness for use in an interlaboratory ring trial involving 46 routine diagnostic laboratories. All laboratories tested five strains (one reference strain and four field strains) against a total of 22 different antimicrobial agents. Gram-negative strains were tested against 16 different antimicrobial agents and Gram-positive strains against 14 different antimicrobial agents. Tests were performed once a week for three consecutive weeks. At least 80% of the results determined by 35 of the 46 participating laboratories were within the expected range (mode MIC
±
1 dilution step), with the 18 participating laboratories experienced in MIC determination showing a slightly higher mean percentage of accurate results (89.3% reproducible results) than the 28 non-experienced laboratories (86.7% reproducible results). The most accurate results were obtained for the
Escherichia coli field strain, whilst the results for the
Streptococcus uberis field strain showed the highest error rate. Among the 22 antimicrobial agents tested, the highest variabilities in the results (mean value for all antimicrobial agents 12.3%) were recorded for ceftiofur (27.8%), penicillin G (20.8%) and cefoperazone (20.6%).</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>16697559</pmid><doi>10.1016/j.ijantimicag.2005.12.011</doi><tpages>9</tpages></addata></record> |
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| ispartof | International journal of antimicrobial agents, 2006-06, Vol.27 (6), p.482-490 |
| issn | 0924-8579 1872-7913 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals Anti-Bacterial Agents - pharmacology Antibiotics. Antiinfectious agents. Antiparasitic agents Antimicrobial agents Bacteria - drug effects Biological and medical sciences Broth microdilution Clinical Laboratory Techniques Escherichia coli Interlaboratory test Medical sciences Microbial Sensitivity Tests - methods Minimum inhibitory concentration Pharmacology. Drug treatments Streptococcus uberis Susceptibility testing |
| title | Results of an interlaboratory test on antimicrobial susceptibility testing of bacteria from animals by broth microdilution |
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