Structure elucidation and 3D solution conformation of the antibiotic enduracidin determined by NMR spectroscopy and molecular dynamics

Enduracidin and ramoplanin belong to the large family of cyclodepsipeptide antibiotics, highly effective against Gram‐positive bacteria. The primary and 3D solution structure of ramoplanin is already well known, and the primary structure of enduracidin has been determined by a combination of chemica...

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Veröffentlicht in:	Magnetic resonance in chemistry 2005-08, Vol.43 (8), p.603-610
Hauptverfasser:	Castiglione, F., Marazzi, A., Meli, M., Colombo, G.
Format:	Artikel
Sprache:	eng
Schlagworte:	1H NMR 3D solution conformation Amides - chemistry Amino Acids - chemistry Anti-Bacterial Agents - chemistry antibiotic Crystallography, X-Ray cyclic peptide depsipeptide Depsipeptides - chemistry enduracidin Glycoproteins - chemistry Hydrogen Bonding Imaging, Three-Dimensional Magnetic Resonance Spectroscopy - methods Models, Chemical Models, Molecular Molecular Conformation molecular dynamics NMR Peptides, Cyclic - chemistry Solutions - chemistry Stereoisomerism Temperature
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