IL-4 influences the differentiation and the susceptibility to activation-induced cell death of human naive CD8+ T cells

It is now well established that the cytokine environment influences the activation, differentiation, proliferation and death of T lymphocytes during the primary response to antigen. Using an in vitro model, we investigated the influence of IL-4, added at the onset of TCR stimulation, on phenotypic a...

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Veröffentlicht in:	International immunology 2006-06, Vol.18 (6), p.827-835
Hauptverfasser:	Riou, Catherine, Dumont, Alain R, Yassine-Diab, Bader, Haddad, Elias K, Sekaly, Rafick-Pierre
Format:	Artikel
Sprache:	eng
Schlagworte:	apoptosis CD8-Positive T-Lymphocytes - immunology Cell Death - drug effects Cell Death - immunology Cell Differentiation - drug effects Cell Differentiation - immunology Cell Survival - drug effects Cell Survival - immunology Cells, Cultured CTL cytokine Genes, bcl-2 - immunology Granzymes Humans Interleukin-2 - immunology Interleukin-2 - pharmacology Interleukin-4 - immunology Interleukin-4 - pharmacology Lymphocyte Activation - drug effects Lymphocyte Activation - immunology Receptors, Antigen, T-Cell - immunology Receptors, Interleukin-2 - immunology Serine Endopeptidases - immunology T cell activation T cell differentiation Up-Regulation - drug effects Up-Regulation - immunology
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