Nandrolone decanoate impairs exercise-induced cardioprotection: Role of antioxidant enzymes
The beneficial effects of exercise in reducing the incidence of cardiovascular diseases are well known and the abuse of anabolic androgenic steroids (AAS) has been associated to cardiovascular disorders. Previous studies showed that heart protection to ischemic events would be mediated by increasing...
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| Veröffentlicht in: | The Journal of steroid biochemistry and molecular biology 2006-06, Vol.99 (4), p.223-230 |
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| creator | Chaves, Elen Aguiar Pereira-Junior, Pedro Paulo Fortunato, Rodrigo Soares Masuda, Masako Oya de Carvalho, Antônio Carlos Campos de Carvalho, Denise Pires Oliveira, Marcus F. Nascimento, José Hamilton Matheus |
| description | The beneficial effects of exercise in reducing the incidence of cardiovascular diseases are well known and the abuse of anabolic androgenic steroids (AAS) has been associated to cardiovascular disorders. Previous studies showed that heart protection to ischemic events would be mediated by increasing the antioxidant enzyme activities. Here, we investigated the impact of exercise and high doses of the AAS nandrolone decanoate (DECA), 10
mg
kg
−1 body weight during 8 weeks, in cardiac tolerance to ischemic events as well as on the activity of antioxidant enzymes in rats. After a global ischemic event, hearts of control trained (CT) group recovered about 70% of left ventricular developed pressure, whereas DECA trained (DT), control sedentary (CS) and DECA sedentary (DS) animals recovered only about 20%. Similarly, heart infarct size was significantly lower in the CT group compared to animals of the three other groups. The activities of the antioxidant enzymes superoxide dismutase (SOD), glutathione peroxidase (GPx) and glutathione reductase (GR) were significantly higher in CT animals than in the other three groups, whereas catalase activity was not affected in any group. Together, these results indicate that chronic treatment with DECA cause an impairment of exercise induction of antioxidant enzyme activities, leading to a reduced cardioprotection upon ischemic events. |
| doi_str_mv | 10.1016/j.jsbmb.2006.01.004 |
| format | Article |
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mg
kg
−1 body weight during 8 weeks, in cardiac tolerance to ischemic events as well as on the activity of antioxidant enzymes in rats. After a global ischemic event, hearts of control trained (CT) group recovered about 70% of left ventricular developed pressure, whereas DECA trained (DT), control sedentary (CS) and DECA sedentary (DS) animals recovered only about 20%. Similarly, heart infarct size was significantly lower in the CT group compared to animals of the three other groups. The activities of the antioxidant enzymes superoxide dismutase (SOD), glutathione peroxidase (GPx) and glutathione reductase (GR) were significantly higher in CT animals than in the other three groups, whereas catalase activity was not affected in any group. Together, these results indicate that chronic treatment with DECA cause an impairment of exercise induction of antioxidant enzyme activities, leading to a reduced cardioprotection upon ischemic events.</description><identifier>ISSN: 0960-0760</identifier><identifier>EISSN: 1879-1220</identifier><identifier>DOI: 10.1016/j.jsbmb.2006.01.004</identifier><identifier>PMID: 16621517</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Anabolic Agents - pharmacology ; Anabolic steroid ; Animals ; Antioxidant enzymes ; Biological and medical sciences ; Cardiology. Vascular system ; Cardioprotection ; Cardiotonic Agents - antagonists & inhibitors ; Exercise ; Fundamental and applied biological sciences. Psychology ; Glutathione Peroxidase - metabolism ; Glutathione Reductase - metabolism ; Heart ; Heart - drug effects ; Ischemia–reperfusion ; Male ; Medical sciences ; Models, Animal ; Myocardial Contraction - drug effects ; Myocardial Infarction - prevention & control ; NADP - metabolism ; Nandrolone - analogs & derivatives ; Nandrolone - pharmacology ; Oxidation-Reduction ; Physical Conditioning, Animal - physiology ; Rats ; Rats, Wistar ; Vertebrates: endocrinology</subject><ispartof>The Journal of steroid biochemistry and molecular biology, 2006-06, Vol.99 (4), p.223-230</ispartof><rights>2006 Elsevier Ltd</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-fb3a007ea6bb148e7b9748fad6afc8bf22ce38bb88d9b3b97099bed76086384c3</citedby><cites>FETCH-LOGICAL-c418t-fb3a007ea6bb148e7b9748fad6afc8bf22ce38bb88d9b3b97099bed76086384c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0960076006000604$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17821295$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16621517$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chaves, Elen Aguiar</creatorcontrib><creatorcontrib>Pereira-Junior, Pedro Paulo</creatorcontrib><creatorcontrib>Fortunato, Rodrigo Soares</creatorcontrib><creatorcontrib>Masuda, Masako Oya</creatorcontrib><creatorcontrib>de Carvalho, Antônio Carlos Campos</creatorcontrib><creatorcontrib>de Carvalho, Denise Pires</creatorcontrib><creatorcontrib>Oliveira, Marcus F.</creatorcontrib><creatorcontrib>Nascimento, José Hamilton Matheus</creatorcontrib><title>Nandrolone decanoate impairs exercise-induced cardioprotection: Role of antioxidant enzymes</title><title>The Journal of steroid biochemistry and molecular biology</title><addtitle>J Steroid Biochem Mol Biol</addtitle><description>The beneficial effects of exercise in reducing the incidence of cardiovascular diseases are well known and the abuse of anabolic androgenic steroids (AAS) has been associated to cardiovascular disorders. Previous studies showed that heart protection to ischemic events would be mediated by increasing the antioxidant enzyme activities. Here, we investigated the impact of exercise and high doses of the AAS nandrolone decanoate (DECA), 10
mg
kg
−1 body weight during 8 weeks, in cardiac tolerance to ischemic events as well as on the activity of antioxidant enzymes in rats. After a global ischemic event, hearts of control trained (CT) group recovered about 70% of left ventricular developed pressure, whereas DECA trained (DT), control sedentary (CS) and DECA sedentary (DS) animals recovered only about 20%. Similarly, heart infarct size was significantly lower in the CT group compared to animals of the three other groups. The activities of the antioxidant enzymes superoxide dismutase (SOD), glutathione peroxidase (GPx) and glutathione reductase (GR) were significantly higher in CT animals than in the other three groups, whereas catalase activity was not affected in any group. Together, these results indicate that chronic treatment with DECA cause an impairment of exercise induction of antioxidant enzyme activities, leading to a reduced cardioprotection upon ischemic events.</description><subject>Anabolic Agents - pharmacology</subject><subject>Anabolic steroid</subject><subject>Animals</subject><subject>Antioxidant enzymes</subject><subject>Biological and medical sciences</subject><subject>Cardiology. Vascular system</subject><subject>Cardioprotection</subject><subject>Cardiotonic Agents - antagonists & inhibitors</subject><subject>Exercise</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glutathione Peroxidase - metabolism</subject><subject>Glutathione Reductase - metabolism</subject><subject>Heart</subject><subject>Heart - drug effects</subject><subject>Ischemia–reperfusion</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Models, Animal</subject><subject>Myocardial Contraction - drug effects</subject><subject>Myocardial Infarction - prevention & control</subject><subject>NADP - metabolism</subject><subject>Nandrolone - analogs & derivatives</subject><subject>Nandrolone - pharmacology</subject><subject>Oxidation-Reduction</subject><subject>Physical Conditioning, Animal - physiology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Vertebrates: endocrinology</subject><issn>0960-0760</issn><issn>1879-1220</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtrFEEQgBtRzBr9BYLMxdxmrJqZ9EPwEEJ8QDAgevLQ9KMGepnpXrtnJcmvt-Mu5KanoqiviqqvGHuN0CEgf7fttsUutusBeAfYAYxP2AalUC32PTxlG1AcWhAcTtiLUrYAMAwonrMT5LzHcxQb9vOriT6nOUVqPDkTk1mpCcvOhFwauqXsQqE2RL935Btnsg9pl9NKbg0pvm--pZmaNDUm1vw2-Bobivd3C5WX7Nlk5kKvjvGU_fh49f3yc3t98-nL5cV160aUazvZwQAIMtxaHCUJq8QoJ-O5mZy0U987GqS1Unplh1oEpSz5epbkgxzdcMrODnPrXr_2VFa9hOJonk2ktC-ay6pLKf5fEAXKkaOq4HAAXU6lZJr0LofF5DuNoB_k663-K18_yNeAusqvXW-O4_d2If_Yc7RdgbdHwBRn5imbWO0-ckL22Kvzyn04cFSt_Q6UdXGBYn1AyNW79in8c5E_vCSlYQ</recordid><startdate>20060601</startdate><enddate>20060601</enddate><creator>Chaves, Elen Aguiar</creator><creator>Pereira-Junior, Pedro Paulo</creator><creator>Fortunato, Rodrigo Soares</creator><creator>Masuda, Masako Oya</creator><creator>de Carvalho, Antônio Carlos Campos</creator><creator>de Carvalho, Denise Pires</creator><creator>Oliveira, Marcus F.</creator><creator>Nascimento, José Hamilton Matheus</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>7X8</scope></search><sort><creationdate>20060601</creationdate><title>Nandrolone decanoate impairs exercise-induced cardioprotection: Role of antioxidant enzymes</title><author>Chaves, Elen Aguiar ; Pereira-Junior, Pedro Paulo ; Fortunato, Rodrigo Soares ; Masuda, Masako Oya ; de Carvalho, Antônio Carlos Campos ; de Carvalho, Denise Pires ; Oliveira, Marcus F. ; Nascimento, José Hamilton Matheus</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-fb3a007ea6bb148e7b9748fad6afc8bf22ce38bb88d9b3b97099bed76086384c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Anabolic Agents - pharmacology</topic><topic>Anabolic steroid</topic><topic>Animals</topic><topic>Antioxidant enzymes</topic><topic>Biological and medical sciences</topic><topic>Cardiology. Vascular system</topic><topic>Cardioprotection</topic><topic>Cardiotonic Agents - antagonists & inhibitors</topic><topic>Exercise</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glutathione Peroxidase - metabolism</topic><topic>Glutathione Reductase - metabolism</topic><topic>Heart</topic><topic>Heart - drug effects</topic><topic>Ischemia–reperfusion</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Models, Animal</topic><topic>Myocardial Contraction - drug effects</topic><topic>Myocardial Infarction - prevention & control</topic><topic>NADP - metabolism</topic><topic>Nandrolone - analogs & derivatives</topic><topic>Nandrolone - pharmacology</topic><topic>Oxidation-Reduction</topic><topic>Physical Conditioning, Animal - physiology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chaves, Elen Aguiar</creatorcontrib><creatorcontrib>Pereira-Junior, Pedro Paulo</creatorcontrib><creatorcontrib>Fortunato, Rodrigo Soares</creatorcontrib><creatorcontrib>Masuda, Masako Oya</creatorcontrib><creatorcontrib>de Carvalho, Antônio Carlos Campos</creatorcontrib><creatorcontrib>de Carvalho, Denise Pires</creatorcontrib><creatorcontrib>Oliveira, Marcus F.</creatorcontrib><creatorcontrib>Nascimento, José Hamilton Matheus</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Physical Education Index</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of steroid biochemistry and molecular biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chaves, Elen Aguiar</au><au>Pereira-Junior, Pedro Paulo</au><au>Fortunato, Rodrigo Soares</au><au>Masuda, Masako Oya</au><au>de Carvalho, Antônio Carlos Campos</au><au>de Carvalho, Denise Pires</au><au>Oliveira, Marcus F.</au><au>Nascimento, José Hamilton Matheus</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nandrolone decanoate impairs exercise-induced cardioprotection: Role of antioxidant enzymes</atitle><jtitle>The Journal of steroid biochemistry and molecular biology</jtitle><addtitle>J Steroid Biochem Mol Biol</addtitle><date>2006-06-01</date><risdate>2006</risdate><volume>99</volume><issue>4</issue><spage>223</spage><epage>230</epage><pages>223-230</pages><issn>0960-0760</issn><eissn>1879-1220</eissn><abstract>The beneficial effects of exercise in reducing the incidence of cardiovascular diseases are well known and the abuse of anabolic androgenic steroids (AAS) has been associated to cardiovascular disorders. Previous studies showed that heart protection to ischemic events would be mediated by increasing the antioxidant enzyme activities. Here, we investigated the impact of exercise and high doses of the AAS nandrolone decanoate (DECA), 10
mg
kg
−1 body weight during 8 weeks, in cardiac tolerance to ischemic events as well as on the activity of antioxidant enzymes in rats. After a global ischemic event, hearts of control trained (CT) group recovered about 70% of left ventricular developed pressure, whereas DECA trained (DT), control sedentary (CS) and DECA sedentary (DS) animals recovered only about 20%. Similarly, heart infarct size was significantly lower in the CT group compared to animals of the three other groups. The activities of the antioxidant enzymes superoxide dismutase (SOD), glutathione peroxidase (GPx) and glutathione reductase (GR) were significantly higher in CT animals than in the other three groups, whereas catalase activity was not affected in any group. Together, these results indicate that chronic treatment with DECA cause an impairment of exercise induction of antioxidant enzyme activities, leading to a reduced cardioprotection upon ischemic events.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>16621517</pmid><doi>10.1016/j.jsbmb.2006.01.004</doi><tpages>8</tpages></addata></record> |
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| ispartof | The Journal of steroid biochemistry and molecular biology, 2006-06, Vol.99 (4), p.223-230 |
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| subjects | Anabolic Agents - pharmacology Anabolic steroid Animals Antioxidant enzymes Biological and medical sciences Cardiology. Vascular system Cardioprotection Cardiotonic Agents - antagonists & inhibitors Exercise Fundamental and applied biological sciences. Psychology Glutathione Peroxidase - metabolism Glutathione Reductase - metabolism Heart Heart - drug effects Ischemia–reperfusion Male Medical sciences Models, Animal Myocardial Contraction - drug effects Myocardial Infarction - prevention & control NADP - metabolism Nandrolone - analogs & derivatives Nandrolone - pharmacology Oxidation-Reduction Physical Conditioning, Animal - physiology Rats Rats, Wistar Vertebrates: endocrinology |
| title | Nandrolone decanoate impairs exercise-induced cardioprotection: Role of antioxidant enzymes |
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