Transcription factors in glutamatergic neurogenesis: Conserved programs in neocortex, cerebellum, and adult hippocampus
Glutamatergic, pyramidal-projection neurons are produced in the embryonic cerebral cortex by a series of genetically programmed fate choices, implemented in large part by developmental transcription factors. Our work has focused on Pax6, Tbr2/Eomes, NeuroD, and Tbr1, which are expressed sequentially...
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| Veröffentlicht in: | Neuroscience research 2006-07, Vol.55 (3), p.223-233 |
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| creator | Hevner, Robert F. Hodge, Rebecca D. Daza, Ray A.M. Englund, Chris |
| description | Glutamatergic, pyramidal-projection neurons are produced in the embryonic cerebral cortex by a series of genetically programmed fate choices, implemented in large part by developmental transcription factors. Our work has focused on Pax6, Tbr2/Eomes, NeuroD, and Tbr1, which are expressed sequentially during the neurogenesis of pyramidal-projection neurons. Recently, we have found that the same transcription factors are expressed, in the same order, during glutamatergic neurogenesis in the adult dentate gyrus, and (with modifications) in the developing cerebellum. While the precise functional significance of this transcription factor expression sequence is unknown, its common appearance in embryonic and adult neurogenesis, and in different brain regions, suggests it is part of a conserved genetic program that specifies general properties of glutamatergic neurons in these regions. Subtypes of glutamatergic neurons (e.g., layer-specific fates in the cortex) are further determined by combinations of transcription factors, superimposed on general sequential programs. These new perspectives on neurogenesis add to the conceptual framework for strategies to engineer neural stem cells for the repair of specific brain circuits. |
| doi_str_mv | 10.1016/j.neures.2006.03.004 |
| format | Article |
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Our work has focused on Pax6, Tbr2/Eomes, NeuroD, and Tbr1, which are expressed sequentially during the neurogenesis of pyramidal-projection neurons. Recently, we have found that the same transcription factors are expressed, in the same order, during glutamatergic neurogenesis in the adult dentate gyrus, and (with modifications) in the developing cerebellum. While the precise functional significance of this transcription factor expression sequence is unknown, its common appearance in embryonic and adult neurogenesis, and in different brain regions, suggests it is part of a conserved genetic program that specifies general properties of glutamatergic neurons in these regions. Subtypes of glutamatergic neurons (e.g., layer-specific fates in the cortex) are further determined by combinations of transcription factors, superimposed on general sequential programs. 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Our work has focused on Pax6, Tbr2/Eomes, NeuroD, and Tbr1, which are expressed sequentially during the neurogenesis of pyramidal-projection neurons. Recently, we have found that the same transcription factors are expressed, in the same order, during glutamatergic neurogenesis in the adult dentate gyrus, and (with modifications) in the developing cerebellum. While the precise functional significance of this transcription factor expression sequence is unknown, its common appearance in embryonic and adult neurogenesis, and in different brain regions, suggests it is part of a conserved genetic program that specifies general properties of glutamatergic neurons in these regions. Subtypes of glutamatergic neurons (e.g., layer-specific fates in the cortex) are further determined by combinations of transcription factors, superimposed on general sequential programs. These new perspectives on neurogenesis add to the conceptual framework for strategies to engineer neural stem cells for the repair of specific brain circuits.</description><subject>Adult neurogenesis</subject><subject>Animals</subject><subject>Cell Differentiation - genetics</subject><subject>Cell Proliferation</subject><subject>Cerebellum - cytology</subject><subject>Cerebellum - embryology</subject><subject>Cerebellum - metabolism</subject><subject>Deep cerebellar nuclei</subject><subject>Eomes</subject><subject>Evolution, Molecular</subject><subject>Gene Expression Regulation, Developmental - genetics</subject><subject>Glutamic Acid - metabolism</subject><subject>Hippocampus - cytology</subject><subject>Hippocampus - metabolism</subject><subject>Humans</subject><subject>Neocortex - cytology</subject><subject>Neocortex - embryology</subject><subject>Neocortex - metabolism</subject><subject>NeuroD</subject><subject>Neurons - cytology</subject><subject>Neurons - metabolism</subject><subject>Pax6</subject><subject>Rhombic lip</subject><subject>Tbr1</subject><subject>Tbr2</subject><subject>Transcription Factors - genetics</subject><subject>Unipolar brush cells</subject><issn>0168-0102</issn><issn>1872-8111</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMFu3CAURVHVqpmk_YOqYtVV7D6Mje0uIkWjJq0UqZt0jTA8TxnZ4AJO0r8vkxkpu6yQ4Nz3LoeQTwxKBkx83ZcO14CxrABECbwEqN-QDevaqugYY2_JJmNdAQyqM3Ie4x4AeF_z9-SMCVExaPsNebwPykUd7JKsd3RUOvkQqXV0N61JzSph2FlND7v8Dh1GG7_RrXcRwwMauuTboObnhEOvfUj4dEk1Bhxwmtb5kipnqDLrlOgfuyxeq3lZ4wfyblRTxI-n84L8vvl-v_1R3P26_bm9vit0wyEVinGD_TAaAVUnGtYNHIVuB8G1qGBoRNuPQgAbW9MwM9YoGiFYrfra5PcK-QX5cpybi_5dMSY526hzM5XbrlGKLkuCmmewPoI6-BgDjnIJdlbhn2QgD8LlXh6Fy4NwCVxm4Tn2-TR_HWY0L6GT4QxcHQHMv3ywGGTUFp1GYwPqJI23r2_4D8DSlh8</recordid><startdate>20060701</startdate><enddate>20060701</enddate><creator>Hevner, Robert F.</creator><creator>Hodge, Rebecca D.</creator><creator>Daza, Ray A.M.</creator><creator>Englund, Chris</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20060701</creationdate><title>Transcription factors in glutamatergic neurogenesis: Conserved programs in neocortex, cerebellum, and adult hippocampus</title><author>Hevner, Robert F. ; Hodge, Rebecca D. ; Daza, Ray A.M. ; Englund, Chris</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c530t-a13de9bfd60286518b3e6c7b63c620b5679f6601f7d51df4e656614a94d6202e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adult neurogenesis</topic><topic>Animals</topic><topic>Cell Differentiation - genetics</topic><topic>Cell Proliferation</topic><topic>Cerebellum - cytology</topic><topic>Cerebellum - embryology</topic><topic>Cerebellum - metabolism</topic><topic>Deep cerebellar nuclei</topic><topic>Eomes</topic><topic>Evolution, Molecular</topic><topic>Gene Expression Regulation, Developmental - genetics</topic><topic>Glutamic Acid - metabolism</topic><topic>Hippocampus - cytology</topic><topic>Hippocampus - metabolism</topic><topic>Humans</topic><topic>Neocortex - cytology</topic><topic>Neocortex - embryology</topic><topic>Neocortex - metabolism</topic><topic>NeuroD</topic><topic>Neurons - cytology</topic><topic>Neurons - metabolism</topic><topic>Pax6</topic><topic>Rhombic lip</topic><topic>Tbr1</topic><topic>Tbr2</topic><topic>Transcription Factors - genetics</topic><topic>Unipolar brush cells</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hevner, Robert F.</creatorcontrib><creatorcontrib>Hodge, Rebecca D.</creatorcontrib><creatorcontrib>Daza, Ray A.M.</creatorcontrib><creatorcontrib>Englund, Chris</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hevner, Robert F.</au><au>Hodge, Rebecca D.</au><au>Daza, Ray A.M.</au><au>Englund, Chris</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transcription factors in glutamatergic neurogenesis: Conserved programs in neocortex, cerebellum, and adult hippocampus</atitle><jtitle>Neuroscience research</jtitle><addtitle>Neurosci Res</addtitle><date>2006-07-01</date><risdate>2006</risdate><volume>55</volume><issue>3</issue><spage>223</spage><epage>233</epage><pages>223-233</pages><issn>0168-0102</issn><eissn>1872-8111</eissn><abstract>Glutamatergic, pyramidal-projection neurons are produced in the embryonic cerebral cortex by a series of genetically programmed fate choices, implemented in large part by developmental transcription factors. 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| subjects | Adult neurogenesis Animals Cell Differentiation - genetics Cell Proliferation Cerebellum - cytology Cerebellum - embryology Cerebellum - metabolism Deep cerebellar nuclei Eomes Evolution, Molecular Gene Expression Regulation, Developmental - genetics Glutamic Acid - metabolism Hippocampus - cytology Hippocampus - metabolism Humans Neocortex - cytology Neocortex - embryology Neocortex - metabolism NeuroD Neurons - cytology Neurons - metabolism Pax6 Rhombic lip Tbr1 Tbr2 Transcription Factors - genetics Unipolar brush cells |
| title | Transcription factors in glutamatergic neurogenesis: Conserved programs in neocortex, cerebellum, and adult hippocampus |
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