Structure–activity studies of a novel series of 5,6-fused heteroaromatic ureas as TRPV1 antagonists

Novel 5,6-fused heteroaromatic ureas were synthesized and evaluated for their activity as TRPV1 antagonists. It was found that 4-aminoindoles and indazoles are the preferential cores for the attachment of ureas. Bulky electron-withdrawing groups in the para-position of the aromatic ring of the urea...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry 2006-07, Vol.14 (14), p.4740-4749
Hauptverfasser:	Drizin, Irene, Gomtsyan, Arthur, Bayburt, Erol K., Schmidt, Robert G., Zheng, Guo Zhu, Perner, Richard J., DiDomenico, Stanley, Koenig, John R., Turner, Sean C., Jinkerson, Tammie K., Brown, Brian S., Keddy, Ryan G., McDonald, Heath A., Honore, Prisca, Wismer, Carol T., Marsh, Kennan C., Wetter, Jill M., Polakowski, James S., Segreti, Jason A., Jarvis, Michael F., Faltynek, Connie R., Lee, Chih-Hung
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics Animals Biological and medical sciences In Vitro Techniques Indole and indazole benzyl ureas Kinetics Male Medical sciences Mice Motor Activity - drug effects Neuropharmacology Pain Measurement Pharmacology. Drug treatments Rats Rats, Sprague-Dawley Structure-Activity Relationship TRPV Cation Channels - antagonists & inhibitors TRPV Cation Channels - metabolism TRPV1 antagonists Urea - analogs & derivatives Urea - chemical synthesis Urea - chemistry Urea - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!