High-sensitivity vibrational imaging with frequency modulation coherent anti-stokes raman scattering (FM CARS) microscopy
We demonstrate a new approach to coherent anti-Stokes Raman scattering (CARS) microscopy that significantly increases the detection sensitivity. CARS signals are generated by collinearly overlapped, tightly focused, and raster scanned pump and Stokes laser beams, whose difference frequency is rapidl...
Gespeichert in:
| Veröffentlicht in: | Optics letters 2006-06, Vol.31 (12), p.1872-1874 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1874 |
|---|---|
| container_issue | 12 |
| container_start_page | 1872 |
| container_title | Optics letters |
| container_volume | 31 |
| creator | GANIKHANOV, Feruz EVANS, Conor L SAAR, Brian G XIE, X. Sunney |
| description | We demonstrate a new approach to coherent anti-Stokes Raman scattering (CARS) microscopy that significantly increases the detection sensitivity. CARS signals are generated by collinearly overlapped, tightly focused, and raster scanned pump and Stokes laser beams, whose difference frequency is rapidly modulated. The resulting amplitude modulation of the CARS signal is detected through a lock-in amplifier. This scheme efficiently suppresses the nonresonant background and allows for the detection of far fewer vibrational oscillators than possible through existing CARS microscopy methods. |
| doi_str_mv | 10.1364/OL.31.001872 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68015232</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>68015232</sourcerecordid><originalsourceid>FETCH-LOGICAL-c362t-3ae3f1b6d3fba29cb1a2afdac6f028006f8f85cfba1afda546dc5258e964b4403</originalsourceid><addsrcrecordid>eNpFkNtLwzAUh4MoOi9vPkteFAU7c2vaPI7hDSYDL88lTZMt2qYzSSf97-3cwKcD53znxzkfAOcYjTHl7G4-G1M8RgjnGdkDI5xSkbBMsH0wQpjxRKSCHIHjED4RQjyj9BAcYZ4RgYQYgf7JLpZJ0C7YaNc29nBtSy-jbZ2soW3kwroF_LFxCY3X3512qodNW3X1HwNVu9ReuwilizYJsf3SAXrZSAeDkjFqv9m_fniB08nr2w1srPJtUO2qPwUHRtZBn-3qCfh4uH-fPiWz-ePzdDJLFOUkJlRqanDJK2pKSYQqsSTSVFJxg0g-fGRyk6dqGOJNO2W8UilJcy04KxlD9ARcbXNXvh3uD7FobFC6rqXTbRcKniOcEkoG8HYLbi4MXpti5QcBvi8wKjaqi_msoLjYqh7wi11uVza6-od3bgfgcgfIQUVtvHTKhn8uy1mWoZT-Ao07iV8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>68015232</pqid></control><display><type>article</type><title>High-sensitivity vibrational imaging with frequency modulation coherent anti-stokes raman scattering (FM CARS) microscopy</title><source>MEDLINE</source><source>Optica Publishing Group Journals</source><creator>GANIKHANOV, Feruz ; EVANS, Conor L ; SAAR, Brian G ; XIE, X. Sunney</creator><creatorcontrib>GANIKHANOV, Feruz ; EVANS, Conor L ; SAAR, Brian G ; XIE, X. Sunney</creatorcontrib><description>We demonstrate a new approach to coherent anti-Stokes Raman scattering (CARS) microscopy that significantly increases the detection sensitivity. CARS signals are generated by collinearly overlapped, tightly focused, and raster scanned pump and Stokes laser beams, whose difference frequency is rapidly modulated. The resulting amplitude modulation of the CARS signal is detected through a lock-in amplifier. This scheme efficiently suppresses the nonresonant background and allows for the detection of far fewer vibrational oscillators than possible through existing CARS microscopy methods.</description><identifier>ISSN: 0146-9592</identifier><identifier>EISSN: 1539-4794</identifier><identifier>DOI: 10.1364/OL.31.001872</identifier><identifier>PMID: 16729099</identifier><identifier>CODEN: OPLEDP</identifier><language>eng</language><publisher>Washington, DC: Optical Society of America</publisher><subject>Exact sciences and technology ; Fundamental areas of phenomenology (including applications) ; Image Enhancement - methods ; Image forming and processing ; Image Interpretation, Computer-Assisted - methods ; Imaging and optical processing ; Instruments, apparatus, components and techniques common to several branches of physics and astronomy ; Lasers ; Light ; Microscopy - methods ; Nonlinear optics ; Optics ; Phantoms, Imaging ; Phase conjugation, optical mixing; photorefractive and kerr effects ; Physics ; Reproducibility of Results ; Scanning probe microscopes, components and techniques ; Scattering, Radiation ; Sensitivity and Specificity ; Spectrum Analysis, Raman - methods ; Tomography, Optical Coherence - methods ; Vibration</subject><ispartof>Optics letters, 2006-06, Vol.31 (12), p.1872-1874</ispartof><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c362t-3ae3f1b6d3fba29cb1a2afdac6f028006f8f85cfba1afda546dc5258e964b4403</citedby><cites>FETCH-LOGICAL-c362t-3ae3f1b6d3fba29cb1a2afdac6f028006f8f85cfba1afda546dc5258e964b4403</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,3245,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17847705$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16729099$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>GANIKHANOV, Feruz</creatorcontrib><creatorcontrib>EVANS, Conor L</creatorcontrib><creatorcontrib>SAAR, Brian G</creatorcontrib><creatorcontrib>XIE, X. Sunney</creatorcontrib><title>High-sensitivity vibrational imaging with frequency modulation coherent anti-stokes raman scattering (FM CARS) microscopy</title><title>Optics letters</title><addtitle>Opt Lett</addtitle><description>We demonstrate a new approach to coherent anti-Stokes Raman scattering (CARS) microscopy that significantly increases the detection sensitivity. CARS signals are generated by collinearly overlapped, tightly focused, and raster scanned pump and Stokes laser beams, whose difference frequency is rapidly modulated. The resulting amplitude modulation of the CARS signal is detected through a lock-in amplifier. This scheme efficiently suppresses the nonresonant background and allows for the detection of far fewer vibrational oscillators than possible through existing CARS microscopy methods.</description><subject>Exact sciences and technology</subject><subject>Fundamental areas of phenomenology (including applications)</subject><subject>Image Enhancement - methods</subject><subject>Image forming and processing</subject><subject>Image Interpretation, Computer-Assisted - methods</subject><subject>Imaging and optical processing</subject><subject>Instruments, apparatus, components and techniques common to several branches of physics and astronomy</subject><subject>Lasers</subject><subject>Light</subject><subject>Microscopy - methods</subject><subject>Nonlinear optics</subject><subject>Optics</subject><subject>Phantoms, Imaging</subject><subject>Phase conjugation, optical mixing; photorefractive and kerr effects</subject><subject>Physics</subject><subject>Reproducibility of Results</subject><subject>Scanning probe microscopes, components and techniques</subject><subject>Scattering, Radiation</subject><subject>Sensitivity and Specificity</subject><subject>Spectrum Analysis, Raman - methods</subject><subject>Tomography, Optical Coherence - methods</subject><subject>Vibration</subject><issn>0146-9592</issn><issn>1539-4794</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkNtLwzAUh4MoOi9vPkteFAU7c2vaPI7hDSYDL88lTZMt2qYzSSf97-3cwKcD53znxzkfAOcYjTHl7G4-G1M8RgjnGdkDI5xSkbBMsH0wQpjxRKSCHIHjED4RQjyj9BAcYZ4RgYQYgf7JLpZJ0C7YaNc29nBtSy-jbZ2soW3kwroF_LFxCY3X3512qodNW3X1HwNVu9ReuwilizYJsf3SAXrZSAeDkjFqv9m_fniB08nr2w1srPJtUO2qPwUHRtZBn-3qCfh4uH-fPiWz-ePzdDJLFOUkJlRqanDJK2pKSYQqsSTSVFJxg0g-fGRyk6dqGOJNO2W8UilJcy04KxlD9ARcbXNXvh3uD7FobFC6rqXTbRcKniOcEkoG8HYLbi4MXpti5QcBvi8wKjaqi_msoLjYqh7wi11uVza6-od3bgfgcgfIQUVtvHTKhn8uy1mWoZT-Ao07iV8</recordid><startdate>20060615</startdate><enddate>20060615</enddate><creator>GANIKHANOV, Feruz</creator><creator>EVANS, Conor L</creator><creator>SAAR, Brian G</creator><creator>XIE, X. Sunney</creator><general>Optical Society of America</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20060615</creationdate><title>High-sensitivity vibrational imaging with frequency modulation coherent anti-stokes raman scattering (FM CARS) microscopy</title><author>GANIKHANOV, Feruz ; EVANS, Conor L ; SAAR, Brian G ; XIE, X. Sunney</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c362t-3ae3f1b6d3fba29cb1a2afdac6f028006f8f85cfba1afda546dc5258e964b4403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Exact sciences and technology</topic><topic>Fundamental areas of phenomenology (including applications)</topic><topic>Image Enhancement - methods</topic><topic>Image forming and processing</topic><topic>Image Interpretation, Computer-Assisted - methods</topic><topic>Imaging and optical processing</topic><topic>Instruments, apparatus, components and techniques common to several branches of physics and astronomy</topic><topic>Lasers</topic><topic>Light</topic><topic>Microscopy - methods</topic><topic>Nonlinear optics</topic><topic>Optics</topic><topic>Phantoms, Imaging</topic><topic>Phase conjugation, optical mixing; photorefractive and kerr effects</topic><topic>Physics</topic><topic>Reproducibility of Results</topic><topic>Scanning probe microscopes, components and techniques</topic><topic>Scattering, Radiation</topic><topic>Sensitivity and Specificity</topic><topic>Spectrum Analysis, Raman - methods</topic><topic>Tomography, Optical Coherence - methods</topic><topic>Vibration</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>GANIKHANOV, Feruz</creatorcontrib><creatorcontrib>EVANS, Conor L</creatorcontrib><creatorcontrib>SAAR, Brian G</creatorcontrib><creatorcontrib>XIE, X. Sunney</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Optics letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>GANIKHANOV, Feruz</au><au>EVANS, Conor L</au><au>SAAR, Brian G</au><au>XIE, X. Sunney</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High-sensitivity vibrational imaging with frequency modulation coherent anti-stokes raman scattering (FM CARS) microscopy</atitle><jtitle>Optics letters</jtitle><addtitle>Opt Lett</addtitle><date>2006-06-15</date><risdate>2006</risdate><volume>31</volume><issue>12</issue><spage>1872</spage><epage>1874</epage><pages>1872-1874</pages><issn>0146-9592</issn><eissn>1539-4794</eissn><coden>OPLEDP</coden><abstract>We demonstrate a new approach to coherent anti-Stokes Raman scattering (CARS) microscopy that significantly increases the detection sensitivity. CARS signals are generated by collinearly overlapped, tightly focused, and raster scanned pump and Stokes laser beams, whose difference frequency is rapidly modulated. The resulting amplitude modulation of the CARS signal is detected through a lock-in amplifier. This scheme efficiently suppresses the nonresonant background and allows for the detection of far fewer vibrational oscillators than possible through existing CARS microscopy methods.</abstract><cop>Washington, DC</cop><pub>Optical Society of America</pub><pmid>16729099</pmid><doi>10.1364/OL.31.001872</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0146-9592 |
| ispartof | Optics letters, 2006-06, Vol.31 (12), p.1872-1874 |
| issn | 0146-9592 1539-4794 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68015232 |
| source | MEDLINE; Optica Publishing Group Journals |
| subjects | Exact sciences and technology Fundamental areas of phenomenology (including applications) Image Enhancement - methods Image forming and processing Image Interpretation, Computer-Assisted - methods Imaging and optical processing Instruments, apparatus, components and techniques common to several branches of physics and astronomy Lasers Light Microscopy - methods Nonlinear optics Optics Phantoms, Imaging Phase conjugation, optical mixing photorefractive and kerr effects Physics Reproducibility of Results Scanning probe microscopes, components and techniques Scattering, Radiation Sensitivity and Specificity Spectrum Analysis, Raman - methods Tomography, Optical Coherence - methods Vibration |
| title | High-sensitivity vibrational imaging with frequency modulation coherent anti-stokes raman scattering (FM CARS) microscopy |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-19T14%3A32%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=High-sensitivity%20vibrational%20imaging%20with%20frequency%20modulation%20coherent%20anti-stokes%20raman%20scattering%20(FM%20CARS)%20microscopy&rft.jtitle=Optics%20letters&rft.au=GANIKHANOV,%20Feruz&rft.date=2006-06-15&rft.volume=31&rft.issue=12&rft.spage=1872&rft.epage=1874&rft.pages=1872-1874&rft.issn=0146-9592&rft.eissn=1539-4794&rft.coden=OPLEDP&rft_id=info:doi/10.1364/OL.31.001872&rft_dat=%3Cproquest_cross%3E68015232%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=68015232&rft_id=info:pmid/16729099&rfr_iscdi=true |