Adhesion of mesenchymal stem cells to polymer scaffolds occurs via distinct ECM ligands and controls their osteogenic differentiation

The osteogenic potential of mesenchymal stem cells (MSCs) cultured on poly(lactide‐co‐glycolide) (PLGA) or poly(caprolactone) (PCL), two widely used polymeric biomaterials that have been reported to differentially support osteogenic differentiation, was compared in these studies. Here we report that...

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Veröffentlicht in:	Journal of biomedical materials research 2006-07, Vol.78A (1), p.73-85
Hauptverfasser:	Chastain, Sara R., Kundu, Anup K., Dhar, Sanjay, Calvert, Jay W., Putnam, Andrew J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Adhesion - physiology Cell Differentiation Cells, Cultured extracellular matrix Extracellular Matrix Proteins - metabolism Gene Expression Regulation - physiology Humans integrins Lactic Acid Ligands Mesenchymal Stem Cell Transplantation Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - physiology osteogenesis Osteogenesis - drug effects Polyglycolic Acid Polymers stem cells Time Factors tissue engineering
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