Grape-seed derived procyanidins interfere with adipogenesis of 3T3-L1 cells at the onset of differentiation
OBJECTIVE: Our group's previous results on the effects of a grape seed procyanidin extract (GSPE) on adipose metabolism showed that peroxisome proliferator-activated receptor- γ (PPAR γ ) plays a central role in the lipolytic effects of GSPE on adipocytes. Since PPAR γ 2 is a main regulator of...
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| Veröffentlicht in: | International Journal of Obesity 2005-08, Vol.29 (8), p.934-941 |
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| container_title | International Journal of Obesity |
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| creator | Pinent, M Bladé, M C Salvadó, M J Arola, L Hackl, H Quackenbush, J Trajanoski, Z Ardévol, A |
| description | OBJECTIVE:
Our group's previous results on the effects of a grape seed procyanidin extract (GSPE) on adipose metabolism showed that peroxisome proliferator-activated receptor-
γ
(PPAR
γ
) plays a central role in the lipolytic effects of GSPE on adipocytes. Since PPAR
γ
2 is a main regulator of the differentiation process of adipocytes, we investigated whether GSPE affects the adipogenesis of 3T3-L1 cells.
DESIGN:
We performed a time point screening by treating 3T3-L1 cells with GSPE during the differentiation process for 24 h.
MEASUREMENTS:
Differentiation markers and differential gene expression due to GSPE treatment (using the microarray technique).
RESULTS:
Twenty four hour-GSPE treatment at the onset of differentiation reduces adipose-specific markers and maintains the expression of preadipocyte marker preadipocyte factor-1 (Pref-1) significantly elevated. These effects were not found in other time points. Microarray analysis of gene expression after GSPE treatment at the early stage of differentiation showed a modified gene expression profile in which cell cycle and growth-related genes were downregulated by GSPE.
CONCLUSION:
These results suggest that GSPE affects adipogenesis, mainly at the induction of differentiation, and that procyanidins may have a new role in which they impede the formation of adipose cells. |
| doi_str_mv | 10.1038/sj.ijo.0802988 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_68014683</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A188448301</galeid><sourcerecordid>A188448301</sourcerecordid><originalsourceid>FETCH-LOGICAL-c460t-7783297158d5e56aa798d9f4596ec44c4c640a9c487c87915be0710270ce306f3</originalsourceid><addsrcrecordid>eNp1kU1vEzEQhlcIREPhyhGtkMpt03HWn8eqogUpEpdyXrne2cRhYwePA-q_x9usFIGEfBjJ88zMO_NW1XsGSwatvqbd0u_iEjSsjNYvqgXjSjaCG_WyWkALqgEhxUX1hmgHAELA6nV1wYRhSnOzqH7cJ3vAhhD7usfkf5V4SNE92eB7H6j2IWMaMGH92-dtbXt_iBsMSJ7qONTtQ9usWe1wHKm2uc5brGMgzFOy98NUGbK32cfwtno12JHw3Rwvq-93nx9uvzTrb_dfb2_WjeMScqOUbldGMaF7gUJaq4zuzcCFkeg4d9xJDtY4rpXTyjDxiKAYrBQ4bEEO7WX16dS3LPLziJS7vadJoQ0Yj9RJDYxL3Rbw4z_gLh5TKNq6FTNtOReTBVqeoI0dsfNhiDlZV16Pe-9iwMGX_xumNee6BXYe_1ywRTvmLcXxOJ2A_gbnzi5FooRDd0h-b9NTx6Cb3O1o1xV3u9ndUvBh1nt83GN_xmc7C3A1A5acHYdkg_N05qQRwJ8Xvz5xVFJhg-m8-H9G_wEWvruG</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>219300516</pqid></control><display><type>article</type><title>Grape-seed derived procyanidins interfere with adipogenesis of 3T3-L1 cells at the onset of differentiation</title><source>MEDLINE</source><source>Nature</source><source>SpringerLink</source><source>EZB Electronic Journals Library</source><creator>Pinent, M ; Bladé, M C ; Salvadó, M J ; Arola, L ; Hackl, H ; Quackenbush, J ; Trajanoski, Z ; Ardévol, A</creator><creatorcontrib>Pinent, M ; Bladé, M C ; Salvadó, M J ; Arola, L ; Hackl, H ; Quackenbush, J ; Trajanoski, Z ; Ardévol, A</creatorcontrib><description>OBJECTIVE:
Our group's previous results on the effects of a grape seed procyanidin extract (GSPE) on adipose metabolism showed that peroxisome proliferator-activated receptor-
γ
(PPAR
γ
) plays a central role in the lipolytic effects of GSPE on adipocytes. Since PPAR
γ
2 is a main regulator of the differentiation process of adipocytes, we investigated whether GSPE affects the adipogenesis of 3T3-L1 cells.
DESIGN:
We performed a time point screening by treating 3T3-L1 cells with GSPE during the differentiation process for 24 h.
MEASUREMENTS:
Differentiation markers and differential gene expression due to GSPE treatment (using the microarray technique).
RESULTS:
Twenty four hour-GSPE treatment at the onset of differentiation reduces adipose-specific markers and maintains the expression of preadipocyte marker preadipocyte factor-1 (Pref-1) significantly elevated. These effects were not found in other time points. Microarray analysis of gene expression after GSPE treatment at the early stage of differentiation showed a modified gene expression profile in which cell cycle and growth-related genes were downregulated by GSPE.
CONCLUSION:
These results suggest that GSPE affects adipogenesis, mainly at the induction of differentiation, and that procyanidins may have a new role in which they impede the formation of adipose cells.</description><identifier>ISSN: 0307-0565</identifier><identifier>EISSN: 1476-5497</identifier><identifier>DOI: 10.1038/sj.ijo.0802988</identifier><identifier>PMID: 15917849</identifier><identifier>CODEN: IJOBDP</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>3T3-L1 Cells ; Adipocytes ; Adipocytes - cytology ; Adipocytes - drug effects ; Adipocytes - metabolism ; Animals ; Antioxidants - pharmacology ; Base Sequence ; Biflavonoids - pharmacology ; Biological and medical sciences ; Biomarkers - analysis ; Catechin - pharmacology ; Cell cycle ; Cell Cycle Proteins - genetics ; Cell Differentiation - drug effects ; Cyclin-dependent kinases ; Dehydrogenases ; Epidemiology ; Flavonoids ; Gene expression ; Gene Expression Regulation - drug effects ; Glucosephosphate Dehydrogenase - genetics ; Glycerol ; Health Promotion and Disease Prevention ; Insulin ; Intercellular Signaling Peptides and Proteins ; Internal Medicine ; Kinases ; Lipids ; Lipids - analysis ; Medical sciences ; Medicine ; Medicine & Public Health ; Membrane Proteins - analysis ; Membrane Proteins - genetics ; Metabolic Diseases ; Metabolism ; Mice ; Microarray Analysis ; Molecular Sequence Data ; Obesity ; PPAR gamma - analysis ; PPAR gamma - genetics ; Proanthocyanidins - pharmacology ; Proteins ; Public Health ; Repressor Proteins - analysis ; Repressor Proteins - genetics ; Reverse Transcriptase Polymerase Chain Reaction ; Seeds ; Triglycerides - analysis ; Vitis</subject><ispartof>International Journal of Obesity, 2005-08, Vol.29 (8), p.934-941</ispartof><rights>Springer Nature Limited 2005</rights><rights>2005 INIST-CNRS</rights><rights>COPYRIGHT 2005 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Aug 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c460t-7783297158d5e56aa798d9f4596ec44c4c640a9c487c87915be0710270ce306f3</citedby><cites>FETCH-LOGICAL-c460t-7783297158d5e56aa798d9f4596ec44c4c640a9c487c87915be0710270ce306f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/sj.ijo.0802988$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/sj.ijo.0802988$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16950483$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15917849$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pinent, M</creatorcontrib><creatorcontrib>Bladé, M C</creatorcontrib><creatorcontrib>Salvadó, M J</creatorcontrib><creatorcontrib>Arola, L</creatorcontrib><creatorcontrib>Hackl, H</creatorcontrib><creatorcontrib>Quackenbush, J</creatorcontrib><creatorcontrib>Trajanoski, Z</creatorcontrib><creatorcontrib>Ardévol, A</creatorcontrib><title>Grape-seed derived procyanidins interfere with adipogenesis of 3T3-L1 cells at the onset of differentiation</title><title>International Journal of Obesity</title><addtitle>Int J Obes</addtitle><addtitle>Int J Obes (Lond)</addtitle><description>OBJECTIVE:
Our group's previous results on the effects of a grape seed procyanidin extract (GSPE) on adipose metabolism showed that peroxisome proliferator-activated receptor-
γ
(PPAR
γ
) plays a central role in the lipolytic effects of GSPE on adipocytes. Since PPAR
γ
2 is a main regulator of the differentiation process of adipocytes, we investigated whether GSPE affects the adipogenesis of 3T3-L1 cells.
DESIGN:
We performed a time point screening by treating 3T3-L1 cells with GSPE during the differentiation process for 24 h.
MEASUREMENTS:
Differentiation markers and differential gene expression due to GSPE treatment (using the microarray technique).
RESULTS:
Twenty four hour-GSPE treatment at the onset of differentiation reduces adipose-specific markers and maintains the expression of preadipocyte marker preadipocyte factor-1 (Pref-1) significantly elevated. These effects were not found in other time points. Microarray analysis of gene expression after GSPE treatment at the early stage of differentiation showed a modified gene expression profile in which cell cycle and growth-related genes were downregulated by GSPE.
CONCLUSION:
These results suggest that GSPE affects adipogenesis, mainly at the induction of differentiation, and that procyanidins may have a new role in which they impede the formation of adipose cells.</description><subject>3T3-L1 Cells</subject><subject>Adipocytes</subject><subject>Adipocytes - cytology</subject><subject>Adipocytes - drug effects</subject><subject>Adipocytes - metabolism</subject><subject>Animals</subject><subject>Antioxidants - pharmacology</subject><subject>Base Sequence</subject><subject>Biflavonoids - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - analysis</subject><subject>Catechin - pharmacology</subject><subject>Cell cycle</subject><subject>Cell Cycle Proteins - genetics</subject><subject>Cell Differentiation - drug effects</subject><subject>Cyclin-dependent kinases</subject><subject>Dehydrogenases</subject><subject>Epidemiology</subject><subject>Flavonoids</subject><subject>Gene expression</subject><subject>Gene Expression Regulation - drug effects</subject><subject>Glucosephosphate Dehydrogenase - genetics</subject><subject>Glycerol</subject><subject>Health Promotion and Disease Prevention</subject><subject>Insulin</subject><subject>Intercellular Signaling Peptides and Proteins</subject><subject>Internal Medicine</subject><subject>Kinases</subject><subject>Lipids</subject><subject>Lipids - analysis</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Membrane Proteins - analysis</subject><subject>Membrane Proteins - genetics</subject><subject>Metabolic Diseases</subject><subject>Metabolism</subject><subject>Mice</subject><subject>Microarray Analysis</subject><subject>Molecular Sequence Data</subject><subject>Obesity</subject><subject>PPAR gamma - analysis</subject><subject>PPAR gamma - genetics</subject><subject>Proanthocyanidins - pharmacology</subject><subject>Proteins</subject><subject>Public Health</subject><subject>Repressor Proteins - analysis</subject><subject>Repressor Proteins - genetics</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>Seeds</subject><subject>Triglycerides - analysis</subject><subject>Vitis</subject><issn>0307-0565</issn><issn>1476-5497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kU1vEzEQhlcIREPhyhGtkMpt03HWn8eqogUpEpdyXrne2cRhYwePA-q_x9usFIGEfBjJ88zMO_NW1XsGSwatvqbd0u_iEjSsjNYvqgXjSjaCG_WyWkALqgEhxUX1hmgHAELA6nV1wYRhSnOzqH7cJ3vAhhD7usfkf5V4SNE92eB7H6j2IWMaMGH92-dtbXt_iBsMSJ7qONTtQ9usWe1wHKm2uc5brGMgzFOy98NUGbK32cfwtno12JHw3Rwvq-93nx9uvzTrb_dfb2_WjeMScqOUbldGMaF7gUJaq4zuzcCFkeg4d9xJDtY4rpXTyjDxiKAYrBQ4bEEO7WX16dS3LPLziJS7vadJoQ0Yj9RJDYxL3Rbw4z_gLh5TKNq6FTNtOReTBVqeoI0dsfNhiDlZV16Pe-9iwMGX_xumNee6BXYe_1ywRTvmLcXxOJ2A_gbnzi5FooRDd0h-b9NTx6Cb3O1o1xV3u9ndUvBh1nt83GN_xmc7C3A1A5acHYdkg_N05qQRwJ8Xvz5xVFJhg-m8-H9G_wEWvruG</recordid><startdate>20050801</startdate><enddate>20050801</enddate><creator>Pinent, M</creator><creator>Bladé, M C</creator><creator>Salvadó, M J</creator><creator>Arola, L</creator><creator>Hackl, H</creator><creator>Quackenbush, J</creator><creator>Trajanoski, Z</creator><creator>Ardévol, A</creator><general>Nature Publishing Group UK</general><general>Nature Publishing</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T2</scope><scope>7TK</scope><scope>7TS</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20050801</creationdate><title>Grape-seed derived procyanidins interfere with adipogenesis of 3T3-L1 cells at the onset of differentiation</title><author>Pinent, M ; Bladé, M C ; Salvadó, M J ; Arola, L ; Hackl, H ; Quackenbush, J ; Trajanoski, Z ; Ardévol, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c460t-7783297158d5e56aa798d9f4596ec44c4c640a9c487c87915be0710270ce306f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>3T3-L1 Cells</topic><topic>Adipocytes</topic><topic>Adipocytes - cytology</topic><topic>Adipocytes - drug effects</topic><topic>Adipocytes - metabolism</topic><topic>Animals</topic><topic>Antioxidants - pharmacology</topic><topic>Base Sequence</topic><topic>Biflavonoids - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - analysis</topic><topic>Catechin - pharmacology</topic><topic>Cell cycle</topic><topic>Cell Cycle Proteins - genetics</topic><topic>Cell Differentiation - drug effects</topic><topic>Cyclin-dependent kinases</topic><topic>Dehydrogenases</topic><topic>Epidemiology</topic><topic>Flavonoids</topic><topic>Gene expression</topic><topic>Gene Expression Regulation - drug effects</topic><topic>Glucosephosphate Dehydrogenase - genetics</topic><topic>Glycerol</topic><topic>Health Promotion and Disease Prevention</topic><topic>Insulin</topic><topic>Intercellular Signaling Peptides and Proteins</topic><topic>Internal Medicine</topic><topic>Kinases</topic><topic>Lipids</topic><topic>Lipids - analysis</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Membrane Proteins - analysis</topic><topic>Membrane Proteins - genetics</topic><topic>Metabolic Diseases</topic><topic>Metabolism</topic><topic>Mice</topic><topic>Microarray Analysis</topic><topic>Molecular Sequence Data</topic><topic>Obesity</topic><topic>PPAR gamma - analysis</topic><topic>PPAR gamma - genetics</topic><topic>Proanthocyanidins - pharmacology</topic><topic>Proteins</topic><topic>Public Health</topic><topic>Repressor Proteins - analysis</topic><topic>Repressor Proteins - genetics</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>Seeds</topic><topic>Triglycerides - analysis</topic><topic>Vitis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pinent, M</creatorcontrib><creatorcontrib>Bladé, M C</creatorcontrib><creatorcontrib>Salvadó, M J</creatorcontrib><creatorcontrib>Arola, L</creatorcontrib><creatorcontrib>Hackl, H</creatorcontrib><creatorcontrib>Quackenbush, J</creatorcontrib><creatorcontrib>Trajanoski, Z</creatorcontrib><creatorcontrib>Ardévol, A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Agricultural Science Collection</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biological Sciences</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>International Journal of Obesity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pinent, M</au><au>Bladé, M C</au><au>Salvadó, M J</au><au>Arola, L</au><au>Hackl, H</au><au>Quackenbush, J</au><au>Trajanoski, Z</au><au>Ardévol, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Grape-seed derived procyanidins interfere with adipogenesis of 3T3-L1 cells at the onset of differentiation</atitle><jtitle>International Journal of Obesity</jtitle><stitle>Int J Obes</stitle><addtitle>Int J Obes (Lond)</addtitle><date>2005-08-01</date><risdate>2005</risdate><volume>29</volume><issue>8</issue><spage>934</spage><epage>941</epage><pages>934-941</pages><issn>0307-0565</issn><eissn>1476-5497</eissn><coden>IJOBDP</coden><abstract>OBJECTIVE:
Our group's previous results on the effects of a grape seed procyanidin extract (GSPE) on adipose metabolism showed that peroxisome proliferator-activated receptor-
γ
(PPAR
γ
) plays a central role in the lipolytic effects of GSPE on adipocytes. Since PPAR
γ
2 is a main regulator of the differentiation process of adipocytes, we investigated whether GSPE affects the adipogenesis of 3T3-L1 cells.
DESIGN:
We performed a time point screening by treating 3T3-L1 cells with GSPE during the differentiation process for 24 h.
MEASUREMENTS:
Differentiation markers and differential gene expression due to GSPE treatment (using the microarray technique).
RESULTS:
Twenty four hour-GSPE treatment at the onset of differentiation reduces adipose-specific markers and maintains the expression of preadipocyte marker preadipocyte factor-1 (Pref-1) significantly elevated. These effects were not found in other time points. Microarray analysis of gene expression after GSPE treatment at the early stage of differentiation showed a modified gene expression profile in which cell cycle and growth-related genes were downregulated by GSPE.
CONCLUSION:
These results suggest that GSPE affects adipogenesis, mainly at the induction of differentiation, and that procyanidins may have a new role in which they impede the formation of adipose cells.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>15917849</pmid><doi>10.1038/sj.ijo.0802988</doi><tpages>8</tpages></addata></record> |
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| ispartof | International Journal of Obesity, 2005-08, Vol.29 (8), p.934-941 |
| issn | 0307-0565 1476-5497 |
| language | eng |
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| source | MEDLINE; Nature; SpringerLink; EZB Electronic Journals Library |
| subjects | 3T3-L1 Cells Adipocytes Adipocytes - cytology Adipocytes - drug effects Adipocytes - metabolism Animals Antioxidants - pharmacology Base Sequence Biflavonoids - pharmacology Biological and medical sciences Biomarkers - analysis Catechin - pharmacology Cell cycle Cell Cycle Proteins - genetics Cell Differentiation - drug effects Cyclin-dependent kinases Dehydrogenases Epidemiology Flavonoids Gene expression Gene Expression Regulation - drug effects Glucosephosphate Dehydrogenase - genetics Glycerol Health Promotion and Disease Prevention Insulin Intercellular Signaling Peptides and Proteins Internal Medicine Kinases Lipids Lipids - analysis Medical sciences Medicine Medicine & Public Health Membrane Proteins - analysis Membrane Proteins - genetics Metabolic Diseases Metabolism Mice Microarray Analysis Molecular Sequence Data Obesity PPAR gamma - analysis PPAR gamma - genetics Proanthocyanidins - pharmacology Proteins Public Health Repressor Proteins - analysis Repressor Proteins - genetics Reverse Transcriptase Polymerase Chain Reaction Seeds Triglycerides - analysis Vitis |
| title | Grape-seed derived procyanidins interfere with adipogenesis of 3T3-L1 cells at the onset of differentiation |
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