Subtherapeutic Ocular Penetration of Caspofungin and Associated Treatment Failure in Candida albicans Endophthalmitis
Candida endophthalmitis represents the most serious ocular complication of candidemia. The pharmacokinetics and pharmacodynamics of fluconazole, amphotericin B, and flucytosine are fairly well established in endophthalmitis therapy. There remains a paucity of clinical data regarding the utility of n...
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| Veröffentlicht in: | Clinical infectious diseases 2005-08, Vol.41 (3), p.e27-e28 |
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| container_title | Clinical infectious diseases |
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| creator | Gauthier, G. M. Nork, T. M. Prince, R. Andes, D. |
| description | Candida endophthalmitis represents the most serious ocular complication of candidemia. The pharmacokinetics and pharmacodynamics of fluconazole, amphotericin B, and flucytosine are fairly well established in endophthalmitis therapy. There remains a paucity of clinical data regarding the utility of new antimycotic agents in the treatment of fungal chorioretinitis and endophthalmitis. We report a case of clinical failure of caspofungin in the management of Candida albicans endophthalmitis associated with poor vitreous penetration. |
| doi_str_mv | 10.1086/431761 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 1058-4838 |
| ispartof | Clinical infectious diseases, 2005-08, Vol.41 (3), p.e27-e28 |
| issn | 1058-4838 1537-6591 |
| language | eng |
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| source | Jstor Complete Legacy; Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adult Amphotericin B - therapeutic use Antifungal Agents - therapeutic use Candida albicans Candidiasis - drug therapy Drug Combinations Echinocandins Endophthalmitis - drug therapy Humans Lipopeptides Male Peptides, Cyclic - therapeutic use Phosphatidylcholines - therapeutic use Phosphatidylglycerols - therapeutic use Treatment Failure |
| title | Subtherapeutic Ocular Penetration of Caspofungin and Associated Treatment Failure in Candida albicans Endophthalmitis |
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