Retrovirus Reverse Transcriptases Containing a Modified YXDD Motif

The YXDD motif, where X is a variable amino acid, is highly conserved among various viral RNA-dependent DNA polymerases. Mutations in the YXDD motif can abolish enzymatic activity, alter the processivity and fidelity of enzymes and decrease virus infectivity. This review provides a summary of the si...

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Veröffentlicht in:	Antiviral Chemistry and Chemotherapy 2005, Vol.16 (3), p.169-182
Hauptverfasser:	Sharma, Prem L, Nurpeisov, Viktoria, Schinazi, Raymond F
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Motifs Amino acids Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Biological and medical sciences Conserved Sequence DNA-directed DNA polymerase Drug Resistance Enzymatic activity Feline immunodeficiency virus HIV Human immunodeficiency virus Human immunodeficiency virus 1 Humans Infectivity Leukemia Medical sciences Murine leukemia virus Mutation Pharmacology. Drug treatments Retroviridae - enzymology Retrovirus Ribonucleic acid RNA RNA-Directed DNA Polymerase - chemistry RNA-Directed DNA Polymerase - genetics Simian immunodeficiency virus Virus Replication
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