Critical role for the oligoadenylate synthetase/RNase L pathway in response to IFN-beta during acute ocular herpes simplex virus type 1 infection

We previously demonstrated that IFN-beta transgene treatment protects mouse trigeminal ganglia (TG) cells from acute HSV-1 infection in vitro. However, IFN-alpha6 transgene treatment does not provide protection against acute HSV-1 infection in vitro, even though equivalent levels of IFN are expresse...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of immunology (1950) 2005-07, Vol.175 (2), p.1100-1106
Hauptverfasser:	Austin, Bobbie Ann, James, Cassandra, Silverman, Robert H, Carr, Daniel J J
Format:	Artikel
Sprache:	eng
Schlagworte:	2',5'-Oligoadenylate Synthetase - biosynthesis 2',5'-Oligoadenylate Synthetase - deficiency 2',5'-Oligoadenylate Synthetase - genetics 2',5'-Oligoadenylate Synthetase - physiology Acute Disease Animals Cercopithecus aethiops DNA-Binding Proteins - biosynthesis eIF-2 Kinase - deficiency eIF-2 Kinase - genetics eIF-2 Kinase - metabolism Endoribonucleases - deficiency Endoribonucleases - genetics Endoribonucleases - physiology Herpes simplex virus 1 Herpesvirus 1, Human - immunology Interferon-alpha - genetics Interferon-beta - administration & dosage Interferon-beta - genetics Interferon-beta - physiology Keratitis, Herpetic - enzymology Keratitis, Herpetic - immunology Keratitis, Herpetic - mortality Keratitis, Herpetic - prevention & control Mice Mice, Inbred C57BL Mice, Inbred ICR Mice, Knockout Phosphorylation Signal Transduction - genetics Signal Transduction - immunology STAT1 Transcription Factor Trans-Activators - biosynthesis Transfection Transgenes Trigeminal Ganglion - metabolism Trigeminal Ganglion - virology Up-Regulation - immunology Vero Cells Viral Load
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!