Acute intestinal obstruction due to intramural haemorrhage in small intestine in a patient with severe haemophilia A and inhibitor
: Patients with severe haemophilia A usually present with joint, gastrointestinal and urinary tract haemorrhage. Bleeding elsewhere is often precipitated by pre‐existing pathology or trauma. We report a patient with severe haemophilia A, who presented with symptoms of acute intestinal obstruction....
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| Veröffentlicht in: | European journal of haematology 2005-08, Vol.75 (2), p.164-166 |
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| container_title | European journal of haematology |
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| creator | Ramadan, Khaled M. A. Lowry, John P. Wilkinson, Alan McNulty, Orla McMullin, Mary F. Jones, Francis G. C. |
| description | : Patients with severe haemophilia A usually present with joint, gastrointestinal and urinary tract haemorrhage. Bleeding elsewhere is often precipitated by pre‐existing pathology or trauma. We report a patient with severe haemophilia A, who presented with symptoms of acute intestinal obstruction. He has a factor VIII inhibitor and receives recombinant factor VIIa on demand at home. The CT scan of abdomen showed dilated small intestine with fluid filled loops and a long segment in the jejunum with marked transmural thickening. There was no other pathology in the small intestine. These appearances were consistent with intramural haemorrhage in the small intestine as the cause of acute obstruction. He was managed conservatively with recombinant factor VIIa and this resulted in resolution of his symptoms. This case highlights an unusual presentation of bleeding in a haemophilia patient. Intestinal obstruction due to haemorrhage in the small intestinal wall is extremely rare and only previously reported in a few haemophilia patients. It also highlights the effectiveness of conservative management with recombinant factor VIIa as opposed to immediate exploratory surgery. |
| doi_str_mv | 10.1111/j.1600-0609.2005.00445.x |
| format | Article |
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A. ; Lowry, John P. ; Wilkinson, Alan ; McNulty, Orla ; McMullin, Mary F. ; Jones, Francis G. C.</creator><creatorcontrib>Ramadan, Khaled M. A. ; Lowry, John P. ; Wilkinson, Alan ; McNulty, Orla ; McMullin, Mary F. ; Jones, Francis G. C.</creatorcontrib><description>: Patients with severe haemophilia A usually present with joint, gastrointestinal and urinary tract haemorrhage. Bleeding elsewhere is often precipitated by pre‐existing pathology or trauma. We report a patient with severe haemophilia A, who presented with symptoms of acute intestinal obstruction. He has a factor VIII inhibitor and receives recombinant factor VIIa on demand at home. The CT scan of abdomen showed dilated small intestine with fluid filled loops and a long segment in the jejunum with marked transmural thickening. There was no other pathology in the small intestine. These appearances were consistent with intramural haemorrhage in the small intestine as the cause of acute obstruction. He was managed conservatively with recombinant factor VIIa and this resulted in resolution of his symptoms. This case highlights an unusual presentation of bleeding in a haemophilia patient. Intestinal obstruction due to haemorrhage in the small intestinal wall is extremely rare and only previously reported in a few haemophilia patients. 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A.</creatorcontrib><creatorcontrib>Lowry, John P.</creatorcontrib><creatorcontrib>Wilkinson, Alan</creatorcontrib><creatorcontrib>McNulty, Orla</creatorcontrib><creatorcontrib>McMullin, Mary F.</creatorcontrib><creatorcontrib>Jones, Francis G. C.</creatorcontrib><title>Acute intestinal obstruction due to intramural haemorrhage in small intestine in a patient with severe haemophilia A and inhibitor</title><title>European journal of haematology</title><addtitle>Eur J Haematol</addtitle><description>: Patients with severe haemophilia A usually present with joint, gastrointestinal and urinary tract haemorrhage. Bleeding elsewhere is often precipitated by pre‐existing pathology or trauma. We report a patient with severe haemophilia A, who presented with symptoms of acute intestinal obstruction. He has a factor VIII inhibitor and receives recombinant factor VIIa on demand at home. The CT scan of abdomen showed dilated small intestine with fluid filled loops and a long segment in the jejunum with marked transmural thickening. There was no other pathology in the small intestine. These appearances were consistent with intramural haemorrhage in the small intestine as the cause of acute obstruction. He was managed conservatively with recombinant factor VIIa and this resulted in resolution of his symptoms. This case highlights an unusual presentation of bleeding in a haemophilia patient. Intestinal obstruction due to haemorrhage in the small intestinal wall is extremely rare and only previously reported in a few haemophilia patients. It also highlights the effectiveness of conservative management with recombinant factor VIIa as opposed to immediate exploratory surgery.</description><subject>Acute Disease</subject><subject>Adult</subject><subject>Antibodies - blood</subject><subject>Factor VIIa - therapeutic use</subject><subject>Factor VIII - immunology</subject><subject>Gastrointestinal Hemorrhage - complications</subject><subject>Gastrointestinal Hemorrhage - etiology</subject><subject>haemophilia A</subject><subject>Hemophilia A - complications</subject><subject>Hemophilia A - immunology</subject><subject>Humans</subject><subject>inhibitor</subject><subject>Intestinal Diseases - complications</subject><subject>Intestinal Diseases - etiology</subject><subject>intestinal obstruction</subject><subject>Intestinal Obstruction - etiology</subject><subject>Intestine, Small</subject><subject>intramural haemorrhage</subject><subject>Male</subject><subject>recombinant factor VIIa</subject><issn>0902-4441</issn><issn>1600-0609</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMtOxCAUhonR6Hh5BcPKXeuhQJ0mbibGa0zc6JpAe2qZ9DIC1XHrk0udiW5lA-H_vgP5CaEMUhbX-TJlOUACORRpBiBTACFkut4hs99gl8yggCwRQrADcuj9EgCygl3sk4MJAsb5jHwtyjEgtX1AH2yvWzoYH9xYBjv0tBqRhmFKne5GF9NGYzc41-jXSaK-0237a_9cabrSwWIf6IcNDfX4jg433qqxrdV0QXVfRbSxxobBHZO9WrceT7b7EXm5uX6-uksen27vrxaPScnzXCY1ItTcQJFjLWRdZIBFwQUawUvJMgOVyUDofA6VlNwgLyFC80xqzAwrGT8iZ5u5Kze8jfHDqrO-xLbVPQ6jV9FkDISM4HwDlm7w3mGtVs522n0qBmrqXy3V1KCaalZT_-qnf7WO6un2jdF0WP2J28IjcLkBPmyLn_8erK4f7uKBfwMgf5Xi</recordid><startdate>200508</startdate><enddate>200508</enddate><creator>Ramadan, Khaled M. A.</creator><creator>Lowry, John P.</creator><creator>Wilkinson, Alan</creator><creator>McNulty, Orla</creator><creator>McMullin, Mary F.</creator><creator>Jones, Francis G. C.</creator><general>Munksgaard International Publishers</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200508</creationdate><title>Acute intestinal obstruction due to intramural haemorrhage in small intestine in a patient with severe haemophilia A and inhibitor</title><author>Ramadan, Khaled M. A. ; Lowry, John P. ; Wilkinson, Alan ; McNulty, Orla ; McMullin, Mary F. ; Jones, Francis G. C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3665-fee0f3b096ef45f920e9934eb43c512b0db204a680d553be3c0f92825ae2b1c13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Acute Disease</topic><topic>Adult</topic><topic>Antibodies - blood</topic><topic>Factor VIIa - therapeutic use</topic><topic>Factor VIII - immunology</topic><topic>Gastrointestinal Hemorrhage - complications</topic><topic>Gastrointestinal Hemorrhage - etiology</topic><topic>haemophilia A</topic><topic>Hemophilia A - complications</topic><topic>Hemophilia A - immunology</topic><topic>Humans</topic><topic>inhibitor</topic><topic>Intestinal Diseases - complications</topic><topic>Intestinal Diseases - etiology</topic><topic>intestinal obstruction</topic><topic>Intestinal Obstruction - etiology</topic><topic>Intestine, Small</topic><topic>intramural haemorrhage</topic><topic>Male</topic><topic>recombinant factor VIIa</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ramadan, Khaled M. A.</creatorcontrib><creatorcontrib>Lowry, John P.</creatorcontrib><creatorcontrib>Wilkinson, Alan</creatorcontrib><creatorcontrib>McNulty, Orla</creatorcontrib><creatorcontrib>McMullin, Mary F.</creatorcontrib><creatorcontrib>Jones, Francis G. C.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of haematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ramadan, Khaled M. A.</au><au>Lowry, John P.</au><au>Wilkinson, Alan</au><au>McNulty, Orla</au><au>McMullin, Mary F.</au><au>Jones, Francis G. C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acute intestinal obstruction due to intramural haemorrhage in small intestine in a patient with severe haemophilia A and inhibitor</atitle><jtitle>European journal of haematology</jtitle><addtitle>Eur J Haematol</addtitle><date>2005-08</date><risdate>2005</risdate><volume>75</volume><issue>2</issue><spage>164</spage><epage>166</epage><pages>164-166</pages><issn>0902-4441</issn><eissn>1600-0609</eissn><abstract>: Patients with severe haemophilia A usually present with joint, gastrointestinal and urinary tract haemorrhage. Bleeding elsewhere is often precipitated by pre‐existing pathology or trauma. We report a patient with severe haemophilia A, who presented with symptoms of acute intestinal obstruction. He has a factor VIII inhibitor and receives recombinant factor VIIa on demand at home. The CT scan of abdomen showed dilated small intestine with fluid filled loops and a long segment in the jejunum with marked transmural thickening. There was no other pathology in the small intestine. These appearances were consistent with intramural haemorrhage in the small intestine as the cause of acute obstruction. He was managed conservatively with recombinant factor VIIa and this resulted in resolution of his symptoms. This case highlights an unusual presentation of bleeding in a haemophilia patient. Intestinal obstruction due to haemorrhage in the small intestinal wall is extremely rare and only previously reported in a few haemophilia patients. It also highlights the effectiveness of conservative management with recombinant factor VIIa as opposed to immediate exploratory surgery.</abstract><cop>Oxford, UK</cop><pub>Munksgaard International Publishers</pub><pmid>16000133</pmid><doi>10.1111/j.1600-0609.2005.00445.x</doi><tpages>3</tpages></addata></record> |
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| ispartof | European journal of haematology, 2005-08, Vol.75 (2), p.164-166 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Acute Disease Adult Antibodies - blood Factor VIIa - therapeutic use Factor VIII - immunology Gastrointestinal Hemorrhage - complications Gastrointestinal Hemorrhage - etiology haemophilia A Hemophilia A - complications Hemophilia A - immunology Humans inhibitor Intestinal Diseases - complications Intestinal Diseases - etiology intestinal obstruction Intestinal Obstruction - etiology Intestine, Small intramural haemorrhage Male recombinant factor VIIa |
| title | Acute intestinal obstruction due to intramural haemorrhage in small intestine in a patient with severe haemophilia A and inhibitor |
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