Characterization and Treatment of Cidofovir-Resistant Vaccinia (WR Strain) Virus Infections in Cell Culture and in Mice

The wild-type (WT) vaccinia (WR strain) virus is highly virulent to mice by intranasal inoculation, yet death can be prevented by cidofovir treatment. A cidofovir-resistant (CDV-R) mutant of the virus was developed by 15 Vero cell culture passages in order to determine cross-resistance to other inhi...

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Veröffentlicht in:	Antiviral chemistry & chemotherapy 2005, Vol.16 (3), p.203-211
Hauptverfasser:	Smee, Donald F, Wandersee, Miles K, Bailey, Kevin W, Hostetler, Karl Y, Holy, Antonin, Sidwell, Robert W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral activity Antiviral agents Biological and medical sciences Cell culture Cells, Cultured Cidofovir Cross-resistance Cytosine - analogs & derivatives Cytosine - pharmacology Disease Models, Animal Disease resistance Drug efficacy Drug Resistance - genetics Immunodeficiency Inoculation Medical sciences Mice Mice, Inbred BALB C Mice, SCID Mutants Mutation Organophosphonates - pharmacology Pharmacology. Drug treatments Severe combined immunodeficiency Vaccinia - virology Vaccinia virus Vaccinia virus - drug effects Vaccinia virus - genetics Vaccinia virus - pathogenicity Virulence Virus Replication Viruses
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