Expansion and Hyperactivity of CD1d-Restricted NKT Cells during the Progression of Systemic Lupus Erythematosus in (New Zealand Black x New Zealand White)F1 Mice

CD1d-restricted NKT cells expressing invariant TCR alpha-chain rearrangements (iNKT cells) have been reported to be deficient in humans with a variety of autoimmune syndromes and in certain strains of autoimmune mice. In addition, injection of mice with alpha-galactosylceramide, a specific glycolipi...

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Veröffentlicht in:	The Journal of immunology (1950) 2005-07, Vol.175 (2), p.763-770
Hauptverfasser:	Forestier, Claire, Molano, Alberto, Im, Jin Seon, Dutronc, Yves, Diamond, Betty, Davidson, Anne, Illarionov, Petr A, Besra, Gurdyal S, Porcelli, Steven A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, CD1 - immunology Antigens, CD1d B-Lymphocyte Subsets - immunology Cell Line Cell Proliferation Cells, Cultured Crosses, Genetic Disease Progression Female Galactosylceramides - pharmacology Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor Immunophenotyping Killer Cells, Natural - immunology Killer Cells, Natural - metabolism Killer Cells, Natural - pathology Lupus Erythematosus, Systemic - genetics Lupus Erythematosus, Systemic - immunology Lupus Erythematosus, Systemic - pathology Lymphocyte Activation - genetics Mice Mice, Inbred NOD Mice, Inbred NZB T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism T-Lymphocyte Subsets - pathology Th1 Cells - immunology
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