15-Deoxy-delta12,14-PGJ2 inhibits IL-6-induced Stat3 phosphorylation in lymphocytes

15-deoxy-delta(12,14)-PGJ(2)(15d-PGJ(2)) is a natural ligand that activates the peroxisome proliferators-activated receptor (PPAR) gamma, a member of nuclear receptor family implicated in regulation of lipid metabolism and adipocyte differentiation. Recent studies have shown that 15d-PGJ(2) is the p...

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Veröffentlicht in:	Experimental & molecular medicine 2005-06, Vol.37 (3), p.179-185
Hauptverfasser:	Kim, Hyo Jin, Rho, Young Hee, Choi, Seong Jai, Lee, Young Ho, Cheon, HyeonJoo, Um, Jun Won, Sohn, Jeongwon, Song, Gwan Gyu, Ji, Jong Dae
Format:	Artikel
Sprache:	eng
Schlagworte:	Arthritis, Rheumatoid - metabolism Arthritis, Rheumatoid - pathology Chromans - pharmacology Cycloheximide - pharmacology Dactinomycin - pharmacology DNA-Binding Proteins - metabolism Gene Expression Regulation Humans Hypoglycemic Agents - pharmacology Interleukin-6 - pharmacology Jurkat Cells - metabolism Jurkat Cells - pathology Lymphocytes - cytology Lymphocytes - drug effects Lymphocytes - metabolism NF-kappa B - metabolism Phosphorylation PPAR gamma - metabolism Prostaglandin D2 - analogs & derivatives Prostaglandin D2 - pharmacology Protein Synthesis Inhibitors - pharmacology Signal Transduction STAT1 Transcription Factor STAT3 Transcription Factor Thiazolidinediones - pharmacology Trans-Activators - metabolism
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