Significance of Silver-stained Nucleolar Organizer Regions in Early Diagnosis and Prognosis of Oral Squamous Cell Carcinoma: A Multivariate Analysis
Argyrophilic nucleolar organizer regions (AgNORs) appear to be of diagnostic and prognostic significance in different types of human tumour. The present study examined the AgNOR counts in normal, premalignant and malignant oral mucosa to evaluate their potential as a biological marker for tumour pro...
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| Veröffentlicht in: | In vivo (Athens) 2005-07, Vol.19 (4), p.807-812 |
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| creator | Pillai, K Raveendran Kannan, S Sujathan, K Madhavan, Jayaprakash Abraham, Elizabeth K |
| description | Argyrophilic nucleolar organizer regions (AgNORs) appear to be of diagnostic and prognostic significance in different types
of human tumour. The present study examined the AgNOR counts in normal, premalignant and malignant oral mucosa to evaluate
their potential as a biological marker for tumour progression and a prognostic predictor for treatment outcome in oral carcinomas.
The Spearmann's rank correlation analysis between AgNOR counts and various stages of tumour progression in oral mucosa exhibited
a highly significant positive coefficient (r s =0.7969; pâ¤0.001), thus indicating the role of AgNORs in the early diagnosis of potentially malignant oral leukoplakia. When
analyzing the prognostic significance of AgNOR in oral carcinomas, mean count >2.8 concurred with poor prognosis in both univariate
and multivariate analysis. Along with AgNOR counts, the T-status of disease was also found to be an independent predictor
for treatment outcome in multivariate analysis. Thus T3 and T4 tumours, with mean AgNOR counts more than 2.8, are aggressive
and may exhibit resistance to current treatment protocols. |
| format | Article |
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of human tumour. The present study examined the AgNOR counts in normal, premalignant and malignant oral mucosa to evaluate
their potential as a biological marker for tumour progression and a prognostic predictor for treatment outcome in oral carcinomas.
The Spearmann's rank correlation analysis between AgNOR counts and various stages of tumour progression in oral mucosa exhibited
a highly significant positive coefficient (r s =0.7969; pâ¤0.001), thus indicating the role of AgNORs in the early diagnosis of potentially malignant oral leukoplakia. When
analyzing the prognostic significance of AgNOR in oral carcinomas, mean count >2.8 concurred with poor prognosis in both univariate
and multivariate analysis. Along with AgNOR counts, the T-status of disease was also found to be an independent predictor
for treatment outcome in multivariate analysis. Thus T3 and T4 tumours, with mean AgNOR counts more than 2.8, are aggressive
and may exhibit resistance to current treatment protocols.</description><identifier>ISSN: 0258-851X</identifier><identifier>EISSN: 1791-7549</identifier><identifier>PMID: 16001464</identifier><language>eng</language><publisher>Greece: International Institute of Anticancer Research</publisher><subject>Carcinoma, Squamous Cell - diagnosis ; Carcinoma, Squamous Cell - secondary ; Disease Progression ; Early Diagnosis ; Humans ; Leukoplakia, Oral - pathology ; Mouth Mucosa - pathology ; Mouth Neoplasms - diagnosis ; Mouth Neoplasms - pathology ; Multivariate Analysis ; Neoplasm Staging ; Nucleolus Organizer Region - pathology ; Prognosis ; Silver Staining - methods</subject><ispartof>In vivo (Athens), 2005-07, Vol.19 (4), p.807-812</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16001464$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pillai, K Raveendran</creatorcontrib><creatorcontrib>Kannan, S</creatorcontrib><creatorcontrib>Sujathan, K</creatorcontrib><creatorcontrib>Madhavan, Jayaprakash</creatorcontrib><creatorcontrib>Abraham, Elizabeth K</creatorcontrib><title>Significance of Silver-stained Nucleolar Organizer Regions in Early Diagnosis and Prognosis of Oral Squamous Cell Carcinoma: A Multivariate Analysis</title><title>In vivo (Athens)</title><addtitle>In Vivo</addtitle><description>Argyrophilic nucleolar organizer regions (AgNORs) appear to be of diagnostic and prognostic significance in different types
of human tumour. The present study examined the AgNOR counts in normal, premalignant and malignant oral mucosa to evaluate
their potential as a biological marker for tumour progression and a prognostic predictor for treatment outcome in oral carcinomas.
The Spearmann's rank correlation analysis between AgNOR counts and various stages of tumour progression in oral mucosa exhibited
a highly significant positive coefficient (r s =0.7969; pâ¤0.001), thus indicating the role of AgNORs in the early diagnosis of potentially malignant oral leukoplakia. When
analyzing the prognostic significance of AgNOR in oral carcinomas, mean count >2.8 concurred with poor prognosis in both univariate
and multivariate analysis. Along with AgNOR counts, the T-status of disease was also found to be an independent predictor
for treatment outcome in multivariate analysis. Thus T3 and T4 tumours, with mean AgNOR counts more than 2.8, are aggressive
and may exhibit resistance to current treatment protocols.</description><subject>Carcinoma, Squamous Cell - diagnosis</subject><subject>Carcinoma, Squamous Cell - secondary</subject><subject>Disease Progression</subject><subject>Early Diagnosis</subject><subject>Humans</subject><subject>Leukoplakia, Oral - pathology</subject><subject>Mouth Mucosa - pathology</subject><subject>Mouth Neoplasms - diagnosis</subject><subject>Mouth Neoplasms - pathology</subject><subject>Multivariate Analysis</subject><subject>Neoplasm Staging</subject><subject>Nucleolus Organizer Region - pathology</subject><subject>Prognosis</subject><subject>Silver Staining - methods</subject><issn>0258-851X</issn><issn>1791-7549</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo10M9q20AQBnBREmI3zSuUPZTcBLP6t7u5GTdpC25c4gRyE-PVWJ6wWiW7kov7HH3gCuKehoHffHzMh2QulZGpKgtzlswhK3WqS_k8Sz7G-AJQKYDsIpnJCkAWVTFP_m649bxji96S6Hdiw-5AIY0DsqdG3I_WUe8wiHVo0fMfCuKBWu59FOzFLQZ3FF8ZW99HjgJ9I36F_rRNceuATmzeRuz6MYolOSeWGCz7vsMbsRA_RzfwAQPjQGLh0R2nw0_J-Q5dpKvTvEye7m4fl9_T1frbj-Vile6zXA9poxRIVdqykdvCkgbKQRmojN4BbaHIsqqQiE3RbDNTVmByzI2tUBmystFlfplcv-e-hv5tpDjUHUc7dURPU9260gBaSzPBzyc4bjtq6tfAHYZj_f-PE_jyDvbc7n9zoDp26NzE85oP0tRFrUHl_wAN5n4l</recordid><startdate>20050701</startdate><enddate>20050701</enddate><creator>Pillai, K Raveendran</creator><creator>Kannan, S</creator><creator>Sujathan, K</creator><creator>Madhavan, Jayaprakash</creator><creator>Abraham, Elizabeth K</creator><general>International Institute of Anticancer Research</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20050701</creationdate><title>Significance of Silver-stained Nucleolar Organizer Regions in Early Diagnosis and Prognosis of Oral Squamous Cell Carcinoma: A Multivariate Analysis</title><author>Pillai, K Raveendran ; Kannan, S ; Sujathan, K ; Madhavan, Jayaprakash ; Abraham, Elizabeth K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h238t-d770175c5d1b4ce80e30790698f0eb0422641aad4db2956093a39c6a79ec1d853</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Carcinoma, Squamous Cell - diagnosis</topic><topic>Carcinoma, Squamous Cell - secondary</topic><topic>Disease Progression</topic><topic>Early Diagnosis</topic><topic>Humans</topic><topic>Leukoplakia, Oral - pathology</topic><topic>Mouth Mucosa - pathology</topic><topic>Mouth Neoplasms - diagnosis</topic><topic>Mouth Neoplasms - pathology</topic><topic>Multivariate Analysis</topic><topic>Neoplasm Staging</topic><topic>Nucleolus Organizer Region - pathology</topic><topic>Prognosis</topic><topic>Silver Staining - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pillai, K Raveendran</creatorcontrib><creatorcontrib>Kannan, S</creatorcontrib><creatorcontrib>Sujathan, K</creatorcontrib><creatorcontrib>Madhavan, Jayaprakash</creatorcontrib><creatorcontrib>Abraham, Elizabeth K</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>In vivo (Athens)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pillai, K Raveendran</au><au>Kannan, S</au><au>Sujathan, K</au><au>Madhavan, Jayaprakash</au><au>Abraham, Elizabeth K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Significance of Silver-stained Nucleolar Organizer Regions in Early Diagnosis and Prognosis of Oral Squamous Cell Carcinoma: A Multivariate Analysis</atitle><jtitle>In vivo (Athens)</jtitle><addtitle>In Vivo</addtitle><date>2005-07-01</date><risdate>2005</risdate><volume>19</volume><issue>4</issue><spage>807</spage><epage>812</epage><pages>807-812</pages><issn>0258-851X</issn><eissn>1791-7549</eissn><abstract>Argyrophilic nucleolar organizer regions (AgNORs) appear to be of diagnostic and prognostic significance in different types
of human tumour. The present study examined the AgNOR counts in normal, premalignant and malignant oral mucosa to evaluate
their potential as a biological marker for tumour progression and a prognostic predictor for treatment outcome in oral carcinomas.
The Spearmann's rank correlation analysis between AgNOR counts and various stages of tumour progression in oral mucosa exhibited
a highly significant positive coefficient (r s =0.7969; pâ¤0.001), thus indicating the role of AgNORs in the early diagnosis of potentially malignant oral leukoplakia. When
analyzing the prognostic significance of AgNOR in oral carcinomas, mean count >2.8 concurred with poor prognosis in both univariate
and multivariate analysis. Along with AgNOR counts, the T-status of disease was also found to be an independent predictor
for treatment outcome in multivariate analysis. Thus T3 and T4 tumours, with mean AgNOR counts more than 2.8, are aggressive
and may exhibit resistance to current treatment protocols.</abstract><cop>Greece</cop><pub>International Institute of Anticancer Research</pub><pmid>16001464</pmid><tpages>6</tpages></addata></record> |
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| source | MEDLINE; Free E-Journal (出版社公開部分のみ） |
| subjects | Carcinoma, Squamous Cell - diagnosis Carcinoma, Squamous Cell - secondary Disease Progression Early Diagnosis Humans Leukoplakia, Oral - pathology Mouth Mucosa - pathology Mouth Neoplasms - diagnosis Mouth Neoplasms - pathology Multivariate Analysis Neoplasm Staging Nucleolus Organizer Region - pathology Prognosis Silver Staining - methods |
| title | Significance of Silver-stained Nucleolar Organizer Regions in Early Diagnosis and Prognosis of Oral Squamous Cell Carcinoma: A Multivariate Analysis |
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