Serous borderline tumor of the ovary presenting with cervical lymph node involvement : A report of 3 cases
Supradiaphragmatic lymhadenopathy is extremely rare in patients with a serous borderline ovarian tumor (BOT), and clinically difficult to recognize. We describe 3 cases of serous BOT that primarily presented with arm thrombosis due to supradiaphragmatic lymphadenopathy. In all the 3 cases, fine need...
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| Veröffentlicht in: | The American journal of surgical pathology 2006-06, Vol.30 (6), p.739-743 |
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| container_title | The American journal of surgical pathology |
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| creator | VERBRUGGEN, Marjolijn B VERHEIJEN, René H. M VAN DE GOOT, Frank R. W VAN BEURDEN, Marc DORSMAN, Josephine C VAN DIEST, Paul J |
| description | Supradiaphragmatic lymhadenopathy is extremely rare in patients with a serous borderline ovarian tumor (BOT), and clinically difficult to recognize. We describe 3 cases of serous BOT that primarily presented with arm thrombosis due to supradiaphragmatic lymphadenopathy. In all the 3 cases, fine needle aspiration cytology initially indicated metastatic adenocarcinoma. The primary tumor was not immediately apparent, and multiple diagnostic examinations had to be done before the definitive diagnosis of serous BOT, International Federation of Gynecology and Obstetrics stage IV could be made. In the meanwhile, erroneous therapies had been given in 1 case. After surgical removal of the adnexal masses and full surgical staging, all the 3 patients remained free of disease after a follow-up period of 48 to 84 months. In conclusion, supradiaphragmatic lymph node involvement can be present in patients with serous BOTs, and can even be the presenting symptom. When fine needle aspiration cytology of such a lymph node is compatible with adenocarcinoma of unknown primary, serous BOT should be included in the differential diagnosis and pelvic examination should be performed. |
| doi_str_mv | 10.1097/00000478-200606000-00010 |
| format | Article |
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M ; VAN DE GOOT, Frank R. W ; VAN BEURDEN, Marc ; DORSMAN, Josephine C ; VAN DIEST, Paul J</creator><creatorcontrib>VERBRUGGEN, Marjolijn B ; VERHEIJEN, René H. M ; VAN DE GOOT, Frank R. W ; VAN BEURDEN, Marc ; DORSMAN, Josephine C ; VAN DIEST, Paul J</creatorcontrib><description>Supradiaphragmatic lymhadenopathy is extremely rare in patients with a serous borderline ovarian tumor (BOT), and clinically difficult to recognize. We describe 3 cases of serous BOT that primarily presented with arm thrombosis due to supradiaphragmatic lymphadenopathy. In all the 3 cases, fine needle aspiration cytology initially indicated metastatic adenocarcinoma. The primary tumor was not immediately apparent, and multiple diagnostic examinations had to be done before the definitive diagnosis of serous BOT, International Federation of Gynecology and Obstetrics stage IV could be made. In the meanwhile, erroneous therapies had been given in 1 case. After surgical removal of the adnexal masses and full surgical staging, all the 3 patients remained free of disease after a follow-up period of 48 to 84 months. In conclusion, supradiaphragmatic lymph node involvement can be present in patients with serous BOTs, and can even be the presenting symptom. When fine needle aspiration cytology of such a lymph node is compatible with adenocarcinoma of unknown primary, serous BOT should be included in the differential diagnosis and pelvic examination should be performed.</description><identifier>ISSN: 0147-5185</identifier><identifier>EISSN: 1532-0979</identifier><identifier>DOI: 10.1097/00000478-200606000-00010</identifier><identifier>PMID: 16723852</identifier><identifier>CODEN: AJSPDX</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Adenocarcinoma - pathology ; Adult ; Arm - pathology ; Biological and medical sciences ; Biopsy, Fine-Needle ; Cystadenoma, Serous - metabolism ; Cystadenoma, Serous - pathology ; Diagnosis, Differential ; Female ; Female genital diseases ; Gynecology. Andrology. Obstetrics ; Humans ; Immunohistochemistry ; Inclusion Bodies - pathology ; Investigative techniques, diagnostic techniques (general aspects) ; Lymphatic Diseases - etiology ; Lymphatic Metastasis - pathology ; Lymphatic Metastasis - physiopathology ; Medical sciences ; Ovarian Neoplasms - metabolism ; Ovarian Neoplasms - pathology ; Pathology. Cytology. Biochemistry. Spectrometry. 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The primary tumor was not immediately apparent, and multiple diagnostic examinations had to be done before the definitive diagnosis of serous BOT, International Federation of Gynecology and Obstetrics stage IV could be made. In the meanwhile, erroneous therapies had been given in 1 case. After surgical removal of the adnexal masses and full surgical staging, all the 3 patients remained free of disease after a follow-up period of 48 to 84 months. In conclusion, supradiaphragmatic lymph node involvement can be present in patients with serous BOTs, and can even be the presenting symptom. When fine needle aspiration cytology of such a lymph node is compatible with adenocarcinoma of unknown primary, serous BOT should be included in the differential diagnosis and pelvic examination should be performed.</description><subject>Adenocarcinoma - pathology</subject><subject>Adult</subject><subject>Arm - pathology</subject><subject>Biological and medical sciences</subject><subject>Biopsy, Fine-Needle</subject><subject>Cystadenoma, Serous - metabolism</subject><subject>Cystadenoma, Serous - pathology</subject><subject>Diagnosis, Differential</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Inclusion Bodies - pathology</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Lymphatic Diseases - etiology</subject><subject>Lymphatic Metastasis - pathology</subject><subject>Lymphatic Metastasis - physiopathology</subject><subject>Medical sciences</subject><subject>Ovarian Neoplasms - metabolism</subject><subject>Ovarian Neoplasms - pathology</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. 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Obstetrics</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Inclusion Bodies - pathology</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Lymphatic Diseases - etiology</topic><topic>Lymphatic Metastasis - pathology</topic><topic>Lymphatic Metastasis - physiopathology</topic><topic>Medical sciences</topic><topic>Ovarian Neoplasms - metabolism</topic><topic>Ovarian Neoplasms - pathology</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>Thrombosis - etiology</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>VERBRUGGEN, Marjolijn B</creatorcontrib><creatorcontrib>VERHEIJEN, René H. M</creatorcontrib><creatorcontrib>VAN DE GOOT, Frank R. 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The primary tumor was not immediately apparent, and multiple diagnostic examinations had to be done before the definitive diagnosis of serous BOT, International Federation of Gynecology and Obstetrics stage IV could be made. In the meanwhile, erroneous therapies had been given in 1 case. After surgical removal of the adnexal masses and full surgical staging, all the 3 patients remained free of disease after a follow-up period of 48 to 84 months. In conclusion, supradiaphragmatic lymph node involvement can be present in patients with serous BOTs, and can even be the presenting symptom. When fine needle aspiration cytology of such a lymph node is compatible with adenocarcinoma of unknown primary, serous BOT should be included in the differential diagnosis and pelvic examination should be performed.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>16723852</pmid><doi>10.1097/00000478-200606000-00010</doi><tpages>5</tpages></addata></record> |
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| subjects | Adenocarcinoma - pathology Adult Arm - pathology Biological and medical sciences Biopsy, Fine-Needle Cystadenoma, Serous - metabolism Cystadenoma, Serous - pathology Diagnosis, Differential Female Female genital diseases Gynecology. Andrology. Obstetrics Humans Immunohistochemistry Inclusion Bodies - pathology Investigative techniques, diagnostic techniques (general aspects) Lymphatic Diseases - etiology Lymphatic Metastasis - pathology Lymphatic Metastasis - physiopathology Medical sciences Ovarian Neoplasms - metabolism Ovarian Neoplasms - pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Thrombosis - etiology Tumors |
| title | Serous borderline tumor of the ovary presenting with cervical lymph node involvement : A report of 3 cases |
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