Overexpression of Osteopontin Is Associated with More Aggressive Phenotypes in Human Non–Small Cell Lung Cancer
Purpose: The extracellular matrix (ECM) molecule osteopontin is implicated in many pathologic processes, including inflammation, cell proliferation, ECM invasion, tumor progression, and metastasis. The present study evaluated the clinical and biological importance of osteopontin in human lung cancer...
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| Veröffentlicht in: | Clinical cancer research 2005-07, Vol.11 (13), p.4646-4652 |
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| creator | Hu, Zhi Lin, Dongmei Yuan, Jingsong Xiao, Ting Zhang, Husheng Sun, Wenyue Han, Naijun Ma, Ying Di, Xuebing Gao, Meixia Ma, Jinfang Zhang, Junhang Cheng, Shujun Gao, Yanning |
| description | Purpose: The extracellular matrix (ECM) molecule osteopontin is implicated in many pathologic processes, including inflammation, cell
proliferation, ECM invasion, tumor progression, and metastasis. The present study evaluated the clinical and biological importance
of osteopontin in human lung cancer.
Experimental Design and Results: Tissue microarrays derived from non–small cell lung cancer (NSCLC) patients were analyzed immunohistochemically. Osteopontin
protein expression was observed in 64.5% (205 of 318) of primary tumors and 75.5% (108 of 143) of lymph node metastases, but
in only 27.9% (12 of 43) of normal-appearing bronchial epithelial and pulmonary tissues. Osteopontin expression was associated
with tumor growth, tumor staging, and lymph node invasion. In vitro osteopontin enhanced ECM invasion of NSCLC cells, and an osteopontin antibody abolished this effect. We further analyzed
osteopontin levels in circulating plasma derived from 158 patients with NSCLC, 54 patients of benign pulmonary disease, and
25 healthy donors, and found that the median osteopontin levels for the three groups were 319.1, 161.6, and 17.9 ng/mL, respectively.
Conclusions: Overexpression of osteopontin is common in primary NSCLC and may be important in the development and progression of the cancer.
Osteopontin levels in the plasma may serve as a biomarker for diagnosing or monitoring patients with NSCLC. |
| doi_str_mv | 10.1158/1078-0432.CCR-04-2013 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68008556</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>17386872</sourcerecordid><originalsourceid>FETCH-LOGICAL-c506t-a8b56b30976596a0ee8d6ffca34271af1a35ad796b2fe58e1558109e0687fd643</originalsourceid><addsrcrecordid>eNqFkc1u1DAUhSMEoqXwCCBvQGKRch3HP1mOokIrDQyiZW15kuuJ0SRO7aSlu75D35AnwdMZBDs29ll85_r6nCx7TeGUUq4-UJAqh5IVp3X9LYm8AMqeZMeUc5mzQvCnSf9hjrIXMf4AoCWF8nl2RAUAcC6Os-vVDQb8OQaM0fmBeEtWcUI_-mFyA7mIZBGjb5yZsCW3burIZx-QLDabR8cNkq8dDn66GzGSZDifezOQL374df9w2ZvtltSYjuU8bEhthgbDy-yZNduIrw73Sfb949lVfZ4vV58u6sUybziIKTdqzcWaQSUFr4QBRNUKaxvDykJSY6lh3LSyEuvCIleY_q0oVAhCSduKkp1k7_Zzx-CvZ4yT7l1s0jJmQD9HLRSAShn8F6SSqTS0SCDfg03wMQa0egyuN-FOU9C7UvQucL0LXKdSktC7UpLvzeGBed1j-9d1aCEBbw-AiY3Z2pCCcvEfrqJSgkrc-z3XuU136wLq5jHSVAWa0HRpCU2ZLkUp2G-qk6Rj</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>17386872</pqid></control><display><type>article</type><title>Overexpression of Osteopontin Is Associated with More Aggressive Phenotypes in Human Non–Small Cell Lung Cancer</title><source>MEDLINE</source><source>American Association for Cancer Research</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Hu, Zhi ; Lin, Dongmei ; Yuan, Jingsong ; Xiao, Ting ; Zhang, Husheng ; Sun, Wenyue ; Han, Naijun ; Ma, Ying ; Di, Xuebing ; Gao, Meixia ; Ma, Jinfang ; Zhang, Junhang ; Cheng, Shujun ; Gao, Yanning</creator><creatorcontrib>Hu, Zhi ; Lin, Dongmei ; Yuan, Jingsong ; Xiao, Ting ; Zhang, Husheng ; Sun, Wenyue ; Han, Naijun ; Ma, Ying ; Di, Xuebing ; Gao, Meixia ; Ma, Jinfang ; Zhang, Junhang ; Cheng, Shujun ; Gao, Yanning</creatorcontrib><description>Purpose: The extracellular matrix (ECM) molecule osteopontin is implicated in many pathologic processes, including inflammation, cell
proliferation, ECM invasion, tumor progression, and metastasis. The present study evaluated the clinical and biological importance
of osteopontin in human lung cancer.
Experimental Design and Results: Tissue microarrays derived from non–small cell lung cancer (NSCLC) patients were analyzed immunohistochemically. Osteopontin
protein expression was observed in 64.5% (205 of 318) of primary tumors and 75.5% (108 of 143) of lymph node metastases, but
in only 27.9% (12 of 43) of normal-appearing bronchial epithelial and pulmonary tissues. Osteopontin expression was associated
with tumor growth, tumor staging, and lymph node invasion. In vitro osteopontin enhanced ECM invasion of NSCLC cells, and an osteopontin antibody abolished this effect. We further analyzed
osteopontin levels in circulating plasma derived from 158 patients with NSCLC, 54 patients of benign pulmonary disease, and
25 healthy donors, and found that the median osteopontin levels for the three groups were 319.1, 161.6, and 17.9 ng/mL, respectively.
Conclusions: Overexpression of osteopontin is common in primary NSCLC and may be important in the development and progression of the cancer.
Osteopontin levels in the plasma may serve as a biomarker for diagnosing or monitoring patients with NSCLC.</description><identifier>ISSN: 1078-0432</identifier><identifier>EISSN: 1557-3265</identifier><identifier>DOI: 10.1158/1078-0432.CCR-04-2013</identifier><identifier>PMID: 16000556</identifier><language>eng</language><publisher>Philadelphia, PA: American Association for Cancer Research</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Antineoplastic agents ; Biological and medical sciences ; Carcinoma, Non-Small-Cell Lung - metabolism ; Carcinoma, Non-Small-Cell Lung - pathology ; Cell Line, Tumor ; Cell Movement ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; Immunohistochemistry ; Lung Neoplasms - metabolism ; Lung Neoplasms - pathology ; Male ; Medical sciences ; metastasis ; Middle Aged ; Osteopontin ; Pharmacology. Drug treatments ; plasma ; Plasmids - genetics ; Pneumology ; Sialoglycoproteins - biosynthesis ; Sialoglycoproteins - blood ; Sialoglycoproteins - genetics ; Tissue Array Analysis ; tissue microarray ; Transfection ; Tumors of the respiratory system and mediastinum</subject><ispartof>Clinical cancer research, 2005-07, Vol.11 (13), p.4646-4652</ispartof><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c506t-a8b56b30976596a0ee8d6ffca34271af1a35ad796b2fe58e1558109e0687fd643</citedby><cites>FETCH-LOGICAL-c506t-a8b56b30976596a0ee8d6ffca34271af1a35ad796b2fe58e1558109e0687fd643</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3343,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16917708$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16000556$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hu, Zhi</creatorcontrib><creatorcontrib>Lin, Dongmei</creatorcontrib><creatorcontrib>Yuan, Jingsong</creatorcontrib><creatorcontrib>Xiao, Ting</creatorcontrib><creatorcontrib>Zhang, Husheng</creatorcontrib><creatorcontrib>Sun, Wenyue</creatorcontrib><creatorcontrib>Han, Naijun</creatorcontrib><creatorcontrib>Ma, Ying</creatorcontrib><creatorcontrib>Di, Xuebing</creatorcontrib><creatorcontrib>Gao, Meixia</creatorcontrib><creatorcontrib>Ma, Jinfang</creatorcontrib><creatorcontrib>Zhang, Junhang</creatorcontrib><creatorcontrib>Cheng, Shujun</creatorcontrib><creatorcontrib>Gao, Yanning</creatorcontrib><title>Overexpression of Osteopontin Is Associated with More Aggressive Phenotypes in Human Non–Small Cell Lung Cancer</title><title>Clinical cancer research</title><addtitle>Clin Cancer Res</addtitle><description>Purpose: The extracellular matrix (ECM) molecule osteopontin is implicated in many pathologic processes, including inflammation, cell
proliferation, ECM invasion, tumor progression, and metastasis. The present study evaluated the clinical and biological importance
of osteopontin in human lung cancer.
Experimental Design and Results: Tissue microarrays derived from non–small cell lung cancer (NSCLC) patients were analyzed immunohistochemically. Osteopontin
protein expression was observed in 64.5% (205 of 318) of primary tumors and 75.5% (108 of 143) of lymph node metastases, but
in only 27.9% (12 of 43) of normal-appearing bronchial epithelial and pulmonary tissues. Osteopontin expression was associated
with tumor growth, tumor staging, and lymph node invasion. In vitro osteopontin enhanced ECM invasion of NSCLC cells, and an osteopontin antibody abolished this effect. We further analyzed
osteopontin levels in circulating plasma derived from 158 patients with NSCLC, 54 patients of benign pulmonary disease, and
25 healthy donors, and found that the median osteopontin levels for the three groups were 319.1, 161.6, and 17.9 ng/mL, respectively.
Conclusions: Overexpression of osteopontin is common in primary NSCLC and may be important in the development and progression of the cancer.
Osteopontin levels in the plasma may serve as a biomarker for diagnosing or monitoring patients with NSCLC.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antineoplastic agents</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Non-Small-Cell Lung - metabolism</subject><subject>Carcinoma, Non-Small-Cell Lung - pathology</subject><subject>Cell Line, Tumor</subject><subject>Cell Movement</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Lung Neoplasms - metabolism</subject><subject>Lung Neoplasms - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>metastasis</subject><subject>Middle Aged</subject><subject>Osteopontin</subject><subject>Pharmacology. Drug treatments</subject><subject>plasma</subject><subject>Plasmids - genetics</subject><subject>Pneumology</subject><subject>Sialoglycoproteins - biosynthesis</subject><subject>Sialoglycoproteins - blood</subject><subject>Sialoglycoproteins - genetics</subject><subject>Tissue Array Analysis</subject><subject>tissue microarray</subject><subject>Transfection</subject><subject>Tumors of the respiratory system and mediastinum</subject><issn>1078-0432</issn><issn>1557-3265</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1u1DAUhSMEoqXwCCBvQGKRch3HP1mOokIrDQyiZW15kuuJ0SRO7aSlu75D35AnwdMZBDs29ll85_r6nCx7TeGUUq4-UJAqh5IVp3X9LYm8AMqeZMeUc5mzQvCnSf9hjrIXMf4AoCWF8nl2RAUAcC6Os-vVDQb8OQaM0fmBeEtWcUI_-mFyA7mIZBGjb5yZsCW3burIZx-QLDabR8cNkq8dDn66GzGSZDifezOQL374df9w2ZvtltSYjuU8bEhthgbDy-yZNduIrw73Sfb949lVfZ4vV58u6sUybziIKTdqzcWaQSUFr4QBRNUKaxvDykJSY6lh3LSyEuvCIleY_q0oVAhCSduKkp1k7_Zzx-CvZ4yT7l1s0jJmQD9HLRSAShn8F6SSqTS0SCDfg03wMQa0egyuN-FOU9C7UvQucL0LXKdSktC7UpLvzeGBed1j-9d1aCEBbw-AiY3Z2pCCcvEfrqJSgkrc-z3XuU136wLq5jHSVAWa0HRpCU2ZLkUp2G-qk6Rj</recordid><startdate>20050701</startdate><enddate>20050701</enddate><creator>Hu, Zhi</creator><creator>Lin, Dongmei</creator><creator>Yuan, Jingsong</creator><creator>Xiao, Ting</creator><creator>Zhang, Husheng</creator><creator>Sun, Wenyue</creator><creator>Han, Naijun</creator><creator>Ma, Ying</creator><creator>Di, Xuebing</creator><creator>Gao, Meixia</creator><creator>Ma, Jinfang</creator><creator>Zhang, Junhang</creator><creator>Cheng, Shujun</creator><creator>Gao, Yanning</creator><general>American Association for Cancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20050701</creationdate><title>Overexpression of Osteopontin Is Associated with More Aggressive Phenotypes in Human Non–Small Cell Lung Cancer</title><author>Hu, Zhi ; Lin, Dongmei ; Yuan, Jingsong ; Xiao, Ting ; Zhang, Husheng ; Sun, Wenyue ; Han, Naijun ; Ma, Ying ; Di, Xuebing ; Gao, Meixia ; Ma, Jinfang ; Zhang, Junhang ; Cheng, Shujun ; Gao, Yanning</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c506t-a8b56b30976596a0ee8d6ffca34271af1a35ad796b2fe58e1558109e0687fd643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antineoplastic agents</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Non-Small-Cell Lung - metabolism</topic><topic>Carcinoma, Non-Small-Cell Lung - pathology</topic><topic>Cell Line, Tumor</topic><topic>Cell Movement</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Lung Neoplasms - metabolism</topic><topic>Lung Neoplasms - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>metastasis</topic><topic>Middle Aged</topic><topic>Osteopontin</topic><topic>Pharmacology. Drug treatments</topic><topic>plasma</topic><topic>Plasmids - genetics</topic><topic>Pneumology</topic><topic>Sialoglycoproteins - biosynthesis</topic><topic>Sialoglycoproteins - blood</topic><topic>Sialoglycoproteins - genetics</topic><topic>Tissue Array Analysis</topic><topic>tissue microarray</topic><topic>Transfection</topic><topic>Tumors of the respiratory system and mediastinum</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hu, Zhi</creatorcontrib><creatorcontrib>Lin, Dongmei</creatorcontrib><creatorcontrib>Yuan, Jingsong</creatorcontrib><creatorcontrib>Xiao, Ting</creatorcontrib><creatorcontrib>Zhang, Husheng</creatorcontrib><creatorcontrib>Sun, Wenyue</creatorcontrib><creatorcontrib>Han, Naijun</creatorcontrib><creatorcontrib>Ma, Ying</creatorcontrib><creatorcontrib>Di, Xuebing</creatorcontrib><creatorcontrib>Gao, Meixia</creatorcontrib><creatorcontrib>Ma, Jinfang</creatorcontrib><creatorcontrib>Zhang, Junhang</creatorcontrib><creatorcontrib>Cheng, Shujun</creatorcontrib><creatorcontrib>Gao, Yanning</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical cancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hu, Zhi</au><au>Lin, Dongmei</au><au>Yuan, Jingsong</au><au>Xiao, Ting</au><au>Zhang, Husheng</au><au>Sun, Wenyue</au><au>Han, Naijun</au><au>Ma, Ying</au><au>Di, Xuebing</au><au>Gao, Meixia</au><au>Ma, Jinfang</au><au>Zhang, Junhang</au><au>Cheng, Shujun</au><au>Gao, Yanning</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Overexpression of Osteopontin Is Associated with More Aggressive Phenotypes in Human Non–Small Cell Lung Cancer</atitle><jtitle>Clinical cancer research</jtitle><addtitle>Clin Cancer Res</addtitle><date>2005-07-01</date><risdate>2005</risdate><volume>11</volume><issue>13</issue><spage>4646</spage><epage>4652</epage><pages>4646-4652</pages><issn>1078-0432</issn><eissn>1557-3265</eissn><abstract>Purpose: The extracellular matrix (ECM) molecule osteopontin is implicated in many pathologic processes, including inflammation, cell
proliferation, ECM invasion, tumor progression, and metastasis. The present study evaluated the clinical and biological importance
of osteopontin in human lung cancer.
Experimental Design and Results: Tissue microarrays derived from non–small cell lung cancer (NSCLC) patients were analyzed immunohistochemically. Osteopontin
protein expression was observed in 64.5% (205 of 318) of primary tumors and 75.5% (108 of 143) of lymph node metastases, but
in only 27.9% (12 of 43) of normal-appearing bronchial epithelial and pulmonary tissues. Osteopontin expression was associated
with tumor growth, tumor staging, and lymph node invasion. In vitro osteopontin enhanced ECM invasion of NSCLC cells, and an osteopontin antibody abolished this effect. We further analyzed
osteopontin levels in circulating plasma derived from 158 patients with NSCLC, 54 patients of benign pulmonary disease, and
25 healthy donors, and found that the median osteopontin levels for the three groups were 319.1, 161.6, and 17.9 ng/mL, respectively.
Conclusions: Overexpression of osteopontin is common in primary NSCLC and may be important in the development and progression of the cancer.
Osteopontin levels in the plasma may serve as a biomarker for diagnosing or monitoring patients with NSCLC.</abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>16000556</pmid><doi>10.1158/1078-0432.CCR-04-2013</doi><tpages>7</tpages></addata></record> |
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| ispartof | Clinical cancer research, 2005-07, Vol.11 (13), p.4646-4652 |
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| source | MEDLINE; American Association for Cancer Research; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adult Aged Aged, 80 and over Antineoplastic agents Biological and medical sciences Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - pathology Cell Line, Tumor Cell Movement Enzyme-Linked Immunosorbent Assay Female Humans Immunohistochemistry Lung Neoplasms - metabolism Lung Neoplasms - pathology Male Medical sciences metastasis Middle Aged Osteopontin Pharmacology. Drug treatments plasma Plasmids - genetics Pneumology Sialoglycoproteins - biosynthesis Sialoglycoproteins - blood Sialoglycoproteins - genetics Tissue Array Analysis tissue microarray Transfection Tumors of the respiratory system and mediastinum |
| title | Overexpression of Osteopontin Is Associated with More Aggressive Phenotypes in Human Non–Small Cell Lung Cancer |
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