Melanin-concentrating hormone induces insulin resistance through a mechanism independent of body weight gain

Transgenic hyperexpression of melanin-concentrating hormone (MCH) produces a phenotype of obesity and glucose intolerance. However, it is not known whether under this specific condition, glucose intolerance develops as a direct consequence of hyperexpressed MCH or is secondary to increased adiposity...

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Veröffentlicht in:	Journal of endocrinology 2005-07, Vol.186 (1), p.193-201
Hauptverfasser:	Pereira-da-Silva, Márcio, De Souza, Cláudio T, Gasparetti, Alessandra L, Saad, Mário J A, Velloso, Lício A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue - metabolism Animals Biological and medical sciences Blood Glucose - analysis Endocrine pancreas Fundamental and applied biological sciences. Psychology Gene Expression Glucose Tolerance Test Hormones. Régulation Hypothalamic Hormones - genetics Hypothalamic Hormones - pharmacology Insulin - blood Insulin Receptor Substrate Proteins Insulin Resistance Liver - metabolism Male Melanins - genetics Melanins - pharmacology Muscle, Skeletal - metabolism Oligonucleotides, Antisense - pharmacology Phosphatidylinositol 3-Kinases - metabolism Phosphoproteins - metabolism Pituitary Hormones - genetics Pituitary Hormones - pharmacology Protein-Serine-Threonine Kinases - metabolism Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-akt Rats Rats, Wistar Regular papers Vertebrates: endocrinology Weight Gain
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