Enzymic and non-enzymic cross-linking mechanisms in relation to turnover of collagen: relevance to aging and exercise

The molecular mechanisms involved in the aging of collagen and consequent increase in mechanical strength and stiffness occur in a series of enzymic and non‐enzymic intermolecular cross‐links. The enzymic mechanism involves divalent aldimine intermolecular cross‐links derived from the reaction of al...

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