Upregulation of Bfl-1/A1 in leukemia cells undergoing differentiation by all-trans retinoic acid treatment attenuates chemotherapeutic agent-induced apoptosis

All-trans retinoic acid (ATRA) induces differentiation of NB4 and HL-60 leukemia cells, but not R4 and HL-60/Res cells. Three agents used in cancer therapy, doxorubicin (Dox), arsenic trioxide (As(2)O(3)) and paclitaxel, induce apoptosis, but not differentiation, in all of these cell lines. The indu...

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Veröffentlicht in:	Leukemia 2006-06, Vol.20 (6), p.1009-1016
Hauptverfasser:	XIA, L, WURMBACH, E, WAXMAN, S, JING, Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Antibodies Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects Arsenic Arsenic trioxide Arsenicals - pharmacology Bcl-2 protein Biological and medical sciences Cell death Cell differentiation Cell Differentiation - drug effects Cell Line, Tumor Cell Proliferation - drug effects Chemotherapy Cytotoxicity Differentiation Dose-Response Relationship, Drug Doxorubicin Doxorubicin - pharmacology Gene Silencing - drug effects Hematologic and hematopoietic diseases Hematology HL-60 Cells Humans Leukemia Leukemia - drug therapy Leukemia - metabolism Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Mcl-1 protein Medical sciences Medicine Minor Histocompatibility Antigens mRNA Oncology Oxides - pharmacology Paclitaxel Paclitaxel - pharmacology Proteins Proto-Oncogene Proteins c-bcl-2 - drug effects Proto-Oncogene Proteins c-bcl-2 - genetics Proto-Oncogene Proteins c-bcl-2 - metabolism Remission (Medicine) Retinoic acid RNA, Small Interfering - pharmacology Sensitivity siRNA Tretinoin - pharmacology Up-regulation Up-Regulation - drug effects
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