Towards a lung adenocarcinoma proteome map: Studies with SP-C/c-raf transgenic mice

We report mapping of proteins of adenocarcinomas of the lung as a result of overexpression of the oncogenically activated N‐terminal deletion mutant c‐raf‐1 BxB through usage of the human SP‐C promotor. Proteins from non‐transgenic controls and tumors were extracted with a lysis buffer containing 5 ...

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Veröffentlicht in:	Proteomics (Weinheim) 2006-05, Vol.6 (10), p.3127-3137
Hauptverfasser:	Rütters, Heike, Zürbig, Petra, Halter, Roman, Borlak, Jürgen
Format:	Artikel
Sprache:	eng
Schlagworte:	2-DE Adenocarcinoma - metabolism Adenocarcinoma - secondary Analytical, structural and metabolic biochemistry Animals Biological and medical sciences Electrophoresis, Polyacrylamide Gel Fluorescent Dyes Fundamental and applied biological sciences. Psychology Humans Lung - metabolism Lung adenocarcinoma Lung Neoplasms - metabolism Lung Neoplasms - pathology MALDI-TOF/TOF Mice Mice, Transgenic Miscellaneous Neoplasm Metastasis Organometallic Compounds Peptides - genetics Phenanthrolines Promoter Regions, Genetic Proteins Proteome - biosynthesis Proteome map Proto-Oncogene Proteins c-raf - genetics Pulmonary Surfactant-Associated Protein C - genetics Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Transgenic mice
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