Fasudil hydrochloride hydrate, a Rho-kinase (ROCK) inhibitor, suppresses collagen production and enhances collagenase activity in hepatic stellate cells

: Background/Aims: The Rho–ROCK signaling pathways play an important role in the activation of hepatic stellate cells (HSCs). We investigated the effects of fasudil hydrochloride hydrate (fasudil), a Rho‐kinase (ROCK) inhibitor, on cell growth, collagen production, and collagenase activity in HSCs....

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Veröffentlicht in:	Liver international 2005-08, Vol.25 (4), p.829-838
Hauptverfasser:	Fukushima, Marie, Nakamuta, Makoto, Kohjima, Motoyuki, Kotoh, Kazuhiro, Enjoji, Munechika, Kobayashi, Naoya, Nawata, Hajime
Format:	Artikel
Sprache:	eng
Schlagworte:	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - analogs & derivatives 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - pharmacology Animals Apoptosis - drug effects Cell Movement - drug effects Cell Proliferation - drug effects Cells, Cultured collagen Collagen Type I - genetics Collagen Type I - metabolism collagenase activity Collagenases - biosynthesis Collagenases - genetics fasudil hepatic stellate cell (HSC) Humans Intracellular Signaling Peptides and Proteins - pharmacology Kupffer Cells - drug effects Kupffer Cells - enzymology Kupffer Cells - pathology Male Matrix Metalloproteinase 1 - genetics Matrix Metalloproteinase 1 - metabolism MMP-1 p38 Mitogen-Activated Protein Kinases - metabolism Phosphorylation Protein Kinases - metabolism Protein-Serine-Threonine Kinases - antagonists & inhibitors Rats Rats, Wistar rho-Associated Kinases ROCK inhibitor TIMP-1 Tissue Inhibitor of Metalloproteinase-1 - metabolism Transcription, Genetic - drug effects
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