Circulating Androgen Levels and Self-reported Sexual Function in Women
CONTEXT It has been proposed that low sexual desire and sexual dysfunction are associated with low blood testosterone levels in women. However, evidence to support this is lacking. OBJECTIVE To determine whether women with low self-reported sexual desire and sexual satisfaction are more likely to ha...
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| creator | Davis, Susan R Davison, Sonia L Donath, Susan Bell, Robin J |
| description | CONTEXT It has been proposed that low sexual desire and sexual dysfunction are
associated with low blood testosterone levels in women. However, evidence
to support this is lacking. OBJECTIVE To determine whether women with low self-reported sexual desire and
sexual satisfaction are more likely to have low serum androgen levels than
women without self-reported low sexual desire and sexual satisfaction. DESIGN, SETTING, AND PARTICIPANTS A community-based, cross-sectional study of 1423 women aged 18 to 75
years, who were randomly recruited via the electoral roll in Victoria, Australia,
from April 2002 to August 2003. Women were excluded from the analysis if they
took psychiatric medication, had abnormal thyroid function, documented polycystic
ovarian syndrome, or were younger than 45 years and using oral contraception. MAIN OUTCOME MEASURES Domain scores of the Profile of Female Sexual Function (PFSF) and serum
levels of total and free testosterone, androstenedione, and dehydroepiandrosterone
sulfate. RESULTS A total of 1021 individuals were included in the final analysis. No
clinically significant relationships between having a low score for any PFSF
domain and having a low serum total or free testosterone or androstenedione
level was demonstrated. A low domain score for sexual responsiveness for women
aged 45 years or older was associated with higher odds of having a serum dehydroepiandrosterone
sulfate level below the 10th percentile for this age group (odds ratio [OR],
3.90; 95% confidence interval [CI], 1.54-9.81; P = .004).
For women aged 18 to 44 years, having a low domain score for sexual desire
(OR, 3.86; 95% CI, 1.27-11.67; P = .02),
sexual arousal (OR, 6.39; 95% CI, 2.30-17.73; P |
| doi_str_mv | 10.1001/jama.294.1.91 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_68003608</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><ama_id>201169</ama_id><sourcerecordid>68003608</sourcerecordid><originalsourceid>FETCH-LOGICAL-a353t-aef64c26c8f520e792bea30ff132add68c235d445b83b64fcbdbcd34a343080f3</originalsourceid><addsrcrecordid>eNpd0VFLwzAQAOAgipvTRx98kSLoW2uSS7rkcQynwsAHFR9LmiajI01n0or-ezs2FbyX47iP47hD6JzgjGBMbteqURmVLCOZJAdoTDiIFLgUh2iMsRTplAk2QicxrvEQBKbHaES4lEJIPkaLeR1071RX-1Uy81VoV8YnS_NhXEyUr5Jn42wazKYNndlWn71yyaL3uqtbn9Q-eWsb40_RkVUumrN9nqDXxd3L_CFdPt0_zmfLVAGHLlXG5kzTXAvLKTZTSUujAFtLgKqqyoWmwCvGeCmgzJnVZVXqCpgCBlhgCxN0s5u7Ce17b2JXNHXUxjnlTdvHIhcYQ47FAK_-wXXbBz_sVlBCQBDM6YAu96gvG1MVm1A3KnwVP-cZwPUeqKiVs0F5Xcc_l0sspnTrLnZueMZvl2IyAPgGQVJ7Rw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>211381052</pqid></control><display><type>article</type><title>Circulating Androgen Levels and Self-reported Sexual Function in Women</title><source>MEDLINE</source><source>American Medical Association Journals</source><creator>Davis, Susan R ; Davison, Sonia L ; Donath, Susan ; Bell, Robin J</creator><creatorcontrib>Davis, Susan R ; Davison, Sonia L ; Donath, Susan ; Bell, Robin J</creatorcontrib><description>CONTEXT It has been proposed that low sexual desire and sexual dysfunction are
associated with low blood testosterone levels in women. However, evidence
to support this is lacking. OBJECTIVE To determine whether women with low self-reported sexual desire and
sexual satisfaction are more likely to have low serum androgen levels than
women without self-reported low sexual desire and sexual satisfaction. DESIGN, SETTING, AND PARTICIPANTS A community-based, cross-sectional study of 1423 women aged 18 to 75
years, who were randomly recruited via the electoral roll in Victoria, Australia,
from April 2002 to August 2003. Women were excluded from the analysis if they
took psychiatric medication, had abnormal thyroid function, documented polycystic
ovarian syndrome, or were younger than 45 years and using oral contraception. MAIN OUTCOME MEASURES Domain scores of the Profile of Female Sexual Function (PFSF) and serum
levels of total and free testosterone, androstenedione, and dehydroepiandrosterone
sulfate. RESULTS A total of 1021 individuals were included in the final analysis. No
clinically significant relationships between having a low score for any PFSF
domain and having a low serum total or free testosterone or androstenedione
level was demonstrated. A low domain score for sexual responsiveness for women
aged 45 years or older was associated with higher odds of having a serum dehydroepiandrosterone
sulfate level below the 10th percentile for this age group (odds ratio [OR],
3.90; 95% confidence interval [CI], 1.54-9.81; P = .004).
For women aged 18 to 44 years, having a low domain score for sexual desire
(OR, 3.86; 95% CI, 1.27-11.67; P = .02),
sexual arousal (OR, 6.39; 95% CI, 2.30-17.73; P<.001),
and sexual responsiveness (OR, 6.59; 95% CI, 2.37-18.34; P<.001) was associated with having a dehydroepiandrosterone sulfate
level below the 10th percentile. CONCLUSIONS No single androgen level is predictive of low female sexual function,
and the majority of women with low dehydroepiandrosterone sulfate levels did
not have low sexual function.</description><identifier>ISSN: 0098-7484</identifier><identifier>EISSN: 1538-3598</identifier><identifier>DOI: 10.1001/jama.294.1.91</identifier><identifier>PMID: 15998895</identifier><identifier>CODEN: JAMAAP</identifier><language>eng</language><publisher>Chicago, IL: American Medical Association</publisher><subject>Adolescent ; Adult ; Aged ; Androgens ; Androstenedione - blood ; Biological and medical sciences ; Dehydroepiandrosterone Sulfate - blood ; Female ; General aspects ; Humans ; Libido - physiology ; Medical sciences ; Middle Aged ; ROC Curve ; Sexual behavior ; Sexual Behavior - physiology ; Sexual disorders ; Sexual Dysfunction, Physiological - blood ; Testosterone - blood ; Women</subject><ispartof>JAMA : the journal of the American Medical Association, 2005-07, Vol.294 (1), p.91-96</ispartof><rights>2005 INIST-CNRS</rights><rights>Copyright American Medical Association Jul 6, 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a353t-aef64c26c8f520e792bea30ff132add68c235d445b83b64fcbdbcd34a343080f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://jamanetwork.com/journals/jama/articlepdf/10.1001/jama.294.1.91$$EPDF$$P50$$Gama$$H</linktopdf><linktohtml>$$Uhttps://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.294.1.91$$EHTML$$P50$$Gama$$H</linktohtml><link.rule.ids>64,314,780,784,3340,27924,27925,76489,76492</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16908725$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15998895$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Davis, Susan R</creatorcontrib><creatorcontrib>Davison, Sonia L</creatorcontrib><creatorcontrib>Donath, Susan</creatorcontrib><creatorcontrib>Bell, Robin J</creatorcontrib><title>Circulating Androgen Levels and Self-reported Sexual Function in Women</title><title>JAMA : the journal of the American Medical Association</title><addtitle>JAMA</addtitle><description>CONTEXT It has been proposed that low sexual desire and sexual dysfunction are
associated with low blood testosterone levels in women. However, evidence
to support this is lacking. OBJECTIVE To determine whether women with low self-reported sexual desire and
sexual satisfaction are more likely to have low serum androgen levels than
women without self-reported low sexual desire and sexual satisfaction. DESIGN, SETTING, AND PARTICIPANTS A community-based, cross-sectional study of 1423 women aged 18 to 75
years, who were randomly recruited via the electoral roll in Victoria, Australia,
from April 2002 to August 2003. Women were excluded from the analysis if they
took psychiatric medication, had abnormal thyroid function, documented polycystic
ovarian syndrome, or were younger than 45 years and using oral contraception. MAIN OUTCOME MEASURES Domain scores of the Profile of Female Sexual Function (PFSF) and serum
levels of total and free testosterone, androstenedione, and dehydroepiandrosterone
sulfate. RESULTS A total of 1021 individuals were included in the final analysis. No
clinically significant relationships between having a low score for any PFSF
domain and having a low serum total or free testosterone or androstenedione
level was demonstrated. A low domain score for sexual responsiveness for women
aged 45 years or older was associated with higher odds of having a serum dehydroepiandrosterone
sulfate level below the 10th percentile for this age group (odds ratio [OR],
3.90; 95% confidence interval [CI], 1.54-9.81; P = .004).
For women aged 18 to 44 years, having a low domain score for sexual desire
(OR, 3.86; 95% CI, 1.27-11.67; P = .02),
sexual arousal (OR, 6.39; 95% CI, 2.30-17.73; P<.001),
and sexual responsiveness (OR, 6.59; 95% CI, 2.37-18.34; P<.001) was associated with having a dehydroepiandrosterone sulfate
level below the 10th percentile. CONCLUSIONS No single androgen level is predictive of low female sexual function,
and the majority of women with low dehydroepiandrosterone sulfate levels did
not have low sexual function.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Androgens</subject><subject>Androstenedione - blood</subject><subject>Biological and medical sciences</subject><subject>Dehydroepiandrosterone Sulfate - blood</subject><subject>Female</subject><subject>General aspects</subject><subject>Humans</subject><subject>Libido - physiology</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>ROC Curve</subject><subject>Sexual behavior</subject><subject>Sexual Behavior - physiology</subject><subject>Sexual disorders</subject><subject>Sexual Dysfunction, Physiological - blood</subject><subject>Testosterone - blood</subject><subject>Women</subject><issn>0098-7484</issn><issn>1538-3598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpd0VFLwzAQAOAgipvTRx98kSLoW2uSS7rkcQynwsAHFR9LmiajI01n0or-ezs2FbyX47iP47hD6JzgjGBMbteqURmVLCOZJAdoTDiIFLgUh2iMsRTplAk2QicxrvEQBKbHaES4lEJIPkaLeR1071RX-1Uy81VoV8YnS_NhXEyUr5Jn42wazKYNndlWn71yyaL3uqtbn9Q-eWsb40_RkVUumrN9nqDXxd3L_CFdPt0_zmfLVAGHLlXG5kzTXAvLKTZTSUujAFtLgKqqyoWmwCvGeCmgzJnVZVXqCpgCBlhgCxN0s5u7Ce17b2JXNHXUxjnlTdvHIhcYQ47FAK_-wXXbBz_sVlBCQBDM6YAu96gvG1MVm1A3KnwVP-cZwPUeqKiVs0F5Xcc_l0sspnTrLnZueMZvl2IyAPgGQVJ7Rw</recordid><startdate>20050706</startdate><enddate>20050706</enddate><creator>Davis, Susan R</creator><creator>Davison, Sonia L</creator><creator>Donath, Susan</creator><creator>Bell, Robin J</creator><general>American Medical Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QL</scope><scope>7QP</scope><scope>7TK</scope><scope>7TS</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20050706</creationdate><title>Circulating Androgen Levels and Self-reported Sexual Function in Women</title><author>Davis, Susan R ; Davison, Sonia L ; Donath, Susan ; Bell, Robin J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a353t-aef64c26c8f520e792bea30ff132add68c235d445b83b64fcbdbcd34a343080f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Androgens</topic><topic>Androstenedione - blood</topic><topic>Biological and medical sciences</topic><topic>Dehydroepiandrosterone Sulfate - blood</topic><topic>Female</topic><topic>General aspects</topic><topic>Humans</topic><topic>Libido - physiology</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>ROC Curve</topic><topic>Sexual behavior</topic><topic>Sexual Behavior - physiology</topic><topic>Sexual disorders</topic><topic>Sexual Dysfunction, Physiological - blood</topic><topic>Testosterone - blood</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Davis, Susan R</creatorcontrib><creatorcontrib>Davison, Sonia L</creatorcontrib><creatorcontrib>Donath, Susan</creatorcontrib><creatorcontrib>Bell, Robin J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>JAMA : the journal of the American Medical Association</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Davis, Susan R</au><au>Davison, Sonia L</au><au>Donath, Susan</au><au>Bell, Robin J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Circulating Androgen Levels and Self-reported Sexual Function in Women</atitle><jtitle>JAMA : the journal of the American Medical Association</jtitle><addtitle>JAMA</addtitle><date>2005-07-06</date><risdate>2005</risdate><volume>294</volume><issue>1</issue><spage>91</spage><epage>96</epage><pages>91-96</pages><issn>0098-7484</issn><eissn>1538-3598</eissn><coden>JAMAAP</coden><abstract>CONTEXT It has been proposed that low sexual desire and sexual dysfunction are
associated with low blood testosterone levels in women. However, evidence
to support this is lacking. OBJECTIVE To determine whether women with low self-reported sexual desire and
sexual satisfaction are more likely to have low serum androgen levels than
women without self-reported low sexual desire and sexual satisfaction. DESIGN, SETTING, AND PARTICIPANTS A community-based, cross-sectional study of 1423 women aged 18 to 75
years, who were randomly recruited via the electoral roll in Victoria, Australia,
from April 2002 to August 2003. Women were excluded from the analysis if they
took psychiatric medication, had abnormal thyroid function, documented polycystic
ovarian syndrome, or were younger than 45 years and using oral contraception. MAIN OUTCOME MEASURES Domain scores of the Profile of Female Sexual Function (PFSF) and serum
levels of total and free testosterone, androstenedione, and dehydroepiandrosterone
sulfate. RESULTS A total of 1021 individuals were included in the final analysis. No
clinically significant relationships between having a low score for any PFSF
domain and having a low serum total or free testosterone or androstenedione
level was demonstrated. A low domain score for sexual responsiveness for women
aged 45 years or older was associated with higher odds of having a serum dehydroepiandrosterone
sulfate level below the 10th percentile for this age group (odds ratio [OR],
3.90; 95% confidence interval [CI], 1.54-9.81; P = .004).
For women aged 18 to 44 years, having a low domain score for sexual desire
(OR, 3.86; 95% CI, 1.27-11.67; P = .02),
sexual arousal (OR, 6.39; 95% CI, 2.30-17.73; P<.001),
and sexual responsiveness (OR, 6.59; 95% CI, 2.37-18.34; P<.001) was associated with having a dehydroepiandrosterone sulfate
level below the 10th percentile. CONCLUSIONS No single androgen level is predictive of low female sexual function,
and the majority of women with low dehydroepiandrosterone sulfate levels did
not have low sexual function.</abstract><cop>Chicago, IL</cop><pub>American Medical Association</pub><pmid>15998895</pmid><doi>10.1001/jama.294.1.91</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0098-7484 |
| ispartof | JAMA : the journal of the American Medical Association, 2005-07, Vol.294 (1), p.91-96 |
| issn | 0098-7484 1538-3598 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68003608 |
| source | MEDLINE; American Medical Association Journals |
| subjects | Adolescent Adult Aged Androgens Androstenedione - blood Biological and medical sciences Dehydroepiandrosterone Sulfate - blood Female General aspects Humans Libido - physiology Medical sciences Middle Aged ROC Curve Sexual behavior Sexual Behavior - physiology Sexual disorders Sexual Dysfunction, Physiological - blood Testosterone - blood Women |
| title | Circulating Androgen Levels and Self-reported Sexual Function in Women |
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