POSH, a scaffold protein for JNK signaling, binds to ALG-2 and ALIX in Drosophila

Plenty of SH3s (POSH) functions as a scaffold protein for the Jun N-terminal kinase (JNK) signal transduction pathway, which leads to cell death in mammalian cultured cells and Drosophila. Here, we show that POSH forms a complex with Apoptosis-linked gene-2 (ALG-2) and ALG-2-interacting protein (ALI...

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Veröffentlicht in:	FEBS letters 2006-05, Vol.580 (13), p.3296-3300
Hauptverfasser:	Tsuda, Manabu, Seong, Ki-Hyeon, Aigaki, Toshiro
Format:	Artikel
Sprache:	eng
Schlagworte:	ALG-2 ALG-2-interacting protein X ALIX Animals Apoptosis-linked gene-2 c-Jun N-terminal kinase Calcium-Binding Proteins - genetics Calcium-Binding Proteins - metabolism Carrier Proteins - genetics Carrier Proteins - metabolism Cell death Cytoskeletal Proteins - genetics Cytoskeletal Proteins - metabolism Drosophila Drosophila - chemistry Drosophila - growth & development Drosophila - metabolism Drosophila Proteins - genetics Drosophila Proteins - metabolism Eye - anatomy & histology Eye - growth & development Eye - metabolism Gene Expression Regulation, Developmental Immunoprecipitation JNK MAP Kinase Kinase 4 - metabolism Microfilament Proteins - genetics Microfilament Proteins - metabolism Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Plenty of SH3s POSH Protein Interaction Mapping reverse transcription-polymerase chain reaction RNA, Messenger - analysis RNA, Messenger - metabolism RT-PCR UAS upstream activating sequence
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