Insulin-like growth factor binding proteins initiate cell death and extracellular matrix remodeling in the mammary gland

We have demonstrated that insulin-like growth factor binding protein-5 (IGFBP-5) production by mammary epithelial cells increases dramatically during forced involution of the mammary gland in rats, mice and pigs. We proposed that growth hormone (GH) increases the survival factor IGF-I, whilst prolac...

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Veröffentlicht in:	Domestic animal endocrinology 2005-08, Vol.29 (2), p.274-282
Hauptverfasser:	Flint, D.J., Boutinaud, M., Tonner, E., Wilde, C.J., Hurley, W., Accorsi, P.A., Kolb, A.F., Whitelaw, C.B.A., Beattie, J., Allan, G.J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis binding proteins Cell Death - physiology Cell Survival - physiology Extracellular matrix Extracellular Matrix - physiology Female Growth Hormone - physiology IGFBP-5 Insulin-like growth factor binding protein Insulin-Like Growth Factor Binding Protein 5 - physiology insulin-like growth factor binding protein-5 insulin-like growth factor I Insulin-Like Growth Factor I - physiology Mammary gland mammary glands Mammary Glands, Animal - cytology mammary involution matrix metalloproteinases mice Neoplasms - etiology physiological regulation Plasmin plasminogen system prolactin Prolactin - physiology somatotropin tissue remodeling Transgenic transgenic animals
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