Protected 32P‐Labels in Deoxyribonucleotides: Investigation of Sequence Selectivity of DNA Photocleavage by Enediyne–, Fulvene–, and Acetylene–Lysine Conjugates
Finding a compromise: The sequence selectivity of DNA photocleavage by enediyne–, acetylene–, and fulvene–lysine conjugates was investigated by using labeled DNA oligomers. Since the external 32P label was removed by these photocleavers, the label was protected by translocation inside the oligomer (...
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| Veröffentlicht in: | Angewandte Chemie International Edition 2006-05, Vol.45 (22), p.3666-3670 |
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| container_end_page | 3670 |
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| container_issue | 22 |
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| container_title | Angewandte Chemie International Edition |
| container_volume | 45 |
| creator | Breiner, Boris Schlatterer, Jörg C. Kovalenko, Serguei V. Greenbaum, Nancy L. Alabugin, Igor V. |
| description | Finding a compromise: The sequence selectivity of DNA photocleavage by enediyne–, acetylene–, and fulvene–lysine conjugates was investigated by using labeled DNA oligomers. Since the external 32P label was removed by these photocleavers, the label was protected by translocation inside the oligomer (see figure). The selectivity of cleavage is controlled by a compromise between AT selectivity for binding and G selectivity for electron transfer. |
| doi_str_mv | 10.1002/anie.200504479 |
| format | Article |
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| ispartof | Angewandte Chemie International Edition, 2006-05, Vol.45 (22), p.3666-3670 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Acetylene - chemistry alkynes Cyclopentanes - chemistry Deoxyribonucleotides - chemistry DNA - chemistry DNA Cleavage electron transfer Enediynes - chemistry fulvenes Lysine - chemistry Phosphorus Radioisotopes - chemistry Photochemistry |
| title | Protected 32P‐Labels in Deoxyribonucleotides: Investigation of Sequence Selectivity of DNA Photocleavage by Enediyne–, Fulvene–, and Acetylene–Lysine Conjugates |
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