Aberrant EGFR and Chromosome 7 Associate with Outcome in Laryngeal Cancer
Objectives/Hypothesis: Epidermal growth factor receptor (EGFR) over‐expression has been reported as a prognostic indicator in laryngeal cancer; however, the association with disease outcome has been inconsistent among studies. Here, we use fluorescence in situ hybridization (FISH) in addition to imm...
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| Veröffentlicht in: | The Laryngoscope 2005-07, Vol.115 (7), p.1212-1218 |
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| container_title | The Laryngoscope |
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| creator | Morrison, Larry E. Jacobson, Kristine K. Friedman, Michael Schroeder, James W. Coon, John S. |
| description | Objectives/Hypothesis: Epidermal growth factor receptor (EGFR) over‐expression has been reported as a prognostic indicator in laryngeal cancer; however, the association with disease outcome has been inconsistent among studies. Here, we use fluorescence in situ hybridization (FISH) in addition to immunohistochemistry to assess laryngeal squamous cell carcinoma (SCC) to determine whether FISH can better predict patient outcome.
Study Design: Retrospective study on 59 patients presenting with advanced disease.
Methods:
EGFR and chromosome 7 genomic statuses were measured using FISH, and EGFR expression was assessed by immunohistochemistry on formalin‐fixed, paraffin‐embedded specimens and correlated with outcome in the 59 patients.
Results: EGFR expression was marginally associated with outcome, whereas both EGFR and chromosome 7 FISH status were significantly associated with outcome, and the combination of EGFR and chromosome 7 FISH status provided the strongest association of any two combined parameters (P = .0004). Combining EGFR expression with EGFR and chromosome 7 FISH status provided further improvement (P > .0001).
Conclusions: Measurements of EGFR and chromosome 7 FISH status, and to a lesser extent EGFR expression, have potential value in treatment planning for patients with laryngeal SCC. |
| doi_str_mv | 10.1097/01.MLG.0000163755.21035.8F |
| format | Article |
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Study Design: Retrospective study on 59 patients presenting with advanced disease.
Methods:
EGFR and chromosome 7 genomic statuses were measured using FISH, and EGFR expression was assessed by immunohistochemistry on formalin‐fixed, paraffin‐embedded specimens and correlated with outcome in the 59 patients.
Results: EGFR expression was marginally associated with outcome, whereas both EGFR and chromosome 7 FISH status were significantly associated with outcome, and the combination of EGFR and chromosome 7 FISH status provided the strongest association of any two combined parameters (P = .0004). Combining EGFR expression with EGFR and chromosome 7 FISH status provided further improvement (P > .0001).
Conclusions: Measurements of EGFR and chromosome 7 FISH status, and to a lesser extent EGFR expression, have potential value in treatment planning for patients with laryngeal SCC.</description><identifier>ISSN: 0023-852X</identifier><identifier>EISSN: 1531-4995</identifier><identifier>DOI: 10.1097/01.MLG.0000163755.21035.8F</identifier><identifier>PMID: 15995509</identifier><identifier>CODEN: LARYA8</identifier><language>eng</language><publisher>Hoboken, NJ: John Wiley & Sons, Inc</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Chromosome Aberrations ; Chromosomes, Human, Pair 7 - genetics ; Female ; Genes, erbB-1 - genetics ; Humans ; In Situ Hybridization, Fluorescence ; Laryngeal Neoplasms - genetics ; Laryngeal Neoplasms - mortality ; Laryngeal Neoplasms - pathology ; Male ; Medical sciences ; Middle Aged ; Neoplasm Staging ; Otorhinolaryngology. Stomatology ; Prognosis ; Retrospective Studies ; Survival Rate ; Tumors ; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><ispartof>The Laryngoscope, 2005-07, Vol.115 (7), p.1212-1218</ispartof><rights>Copyright © 2005 The Triological Society</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4483-5c83e425a1d31d49e5bde43c46fbd55e24418b7736f05960b20894630c5167823</citedby><cites>FETCH-LOGICAL-c4483-5c83e425a1d31d49e5bde43c46fbd55e24418b7736f05960b20894630c5167823</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1097%2F01.MLG.0000163755.21035.8F$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1097%2F01.MLG.0000163755.21035.8F$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16945694$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15995509$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Morrison, Larry E.</creatorcontrib><creatorcontrib>Jacobson, Kristine K.</creatorcontrib><creatorcontrib>Friedman, Michael</creatorcontrib><creatorcontrib>Schroeder, James W.</creatorcontrib><creatorcontrib>Coon, John S.</creatorcontrib><title>Aberrant EGFR and Chromosome 7 Associate with Outcome in Laryngeal Cancer</title><title>The Laryngoscope</title><addtitle>The Laryngoscope</addtitle><description>Objectives/Hypothesis: Epidermal growth factor receptor (EGFR) over‐expression has been reported as a prognostic indicator in laryngeal cancer; however, the association with disease outcome has been inconsistent among studies. Here, we use fluorescence in situ hybridization (FISH) in addition to immunohistochemistry to assess laryngeal squamous cell carcinoma (SCC) to determine whether FISH can better predict patient outcome.
Study Design: Retrospective study on 59 patients presenting with advanced disease.
Methods:
EGFR and chromosome 7 genomic statuses were measured using FISH, and EGFR expression was assessed by immunohistochemistry on formalin‐fixed, paraffin‐embedded specimens and correlated with outcome in the 59 patients.
Results: EGFR expression was marginally associated with outcome, whereas both EGFR and chromosome 7 FISH status were significantly associated with outcome, and the combination of EGFR and chromosome 7 FISH status provided the strongest association of any two combined parameters (P = .0004). Combining EGFR expression with EGFR and chromosome 7 FISH status provided further improvement (P > .0001).
Conclusions: Measurements of EGFR and chromosome 7 FISH status, and to a lesser extent EGFR expression, have potential value in treatment planning for patients with laryngeal SCC.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Chromosome Aberrations</subject><subject>Chromosomes, Human, Pair 7 - genetics</subject><subject>Female</subject><subject>Genes, erbB-1 - genetics</subject><subject>Humans</subject><subject>In Situ Hybridization, Fluorescence</subject><subject>Laryngeal Neoplasms - genetics</subject><subject>Laryngeal Neoplasms - mortality</subject><subject>Laryngeal Neoplasms - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Survival Rate</subject><subject>Tumors</subject><subject>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><issn>0023-852X</issn><issn>1531-4995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkM1u1DAURi0EokPhFZCFBLuE69jXjtmNRs20UmhRBaKsLMdxaCA_xc6o9O1xmRGzxpLlhc_3-foQ8oZBzkCr98Dyj_U2h7SY5AoxLxhwzMvqCVkx5CwTWuNTsgIoeFZicXNCXsT4I-GKIzwnJwwTgKBX5GLd-BDstNCzbXVN7dTSzW2YxznOo6eKrmOcXW8XT-_75ZZe7Rb3eNFPtLbhYfru7UA3dnI-vCTPOjtE_-pwnpIv1dnnzXlWX20vNus6c0KUPENXci8KtKzlrBXaY9N6wZ2QXdMi-kIIVjZKcdkBaglNAaUWkoNDJlVZ8FPybt97F-ZfOx8XM_bR-WGwk5930UiltQYuE_hhD7owxxh8Z-5CP6apDQPzKNIAM0mkOYo0f0Waskrh14dXds3o22P0YC4Bbw-Ajc4OXXLo-njkpBaYduKqPXffD_7hP0Yw9fr6G6JgDEExnoqyfVEfF__7X5ENP9OXU9J8vdwaeSmKT9XNuan4HxvXnEg</recordid><startdate>200507</startdate><enddate>200507</enddate><creator>Morrison, Larry E.</creator><creator>Jacobson, Kristine K.</creator><creator>Friedman, Michael</creator><creator>Schroeder, James W.</creator><creator>Coon, John S.</creator><general>John Wiley & Sons, Inc</general><general>Wiley-Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>8BM</scope></search><sort><creationdate>200507</creationdate><title>Aberrant EGFR and Chromosome 7 Associate with Outcome in Laryngeal Cancer</title><author>Morrison, Larry E. ; Jacobson, Kristine K. ; Friedman, Michael ; Schroeder, James W. ; Coon, John S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4483-5c83e425a1d31d49e5bde43c46fbd55e24418b7736f05960b20894630c5167823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Chromosome Aberrations</topic><topic>Chromosomes, Human, Pair 7 - genetics</topic><topic>Female</topic><topic>Genes, erbB-1 - genetics</topic><topic>Humans</topic><topic>In Situ Hybridization, Fluorescence</topic><topic>Laryngeal Neoplasms - genetics</topic><topic>Laryngeal Neoplasms - mortality</topic><topic>Laryngeal Neoplasms - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neoplasm Staging</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Survival Rate</topic><topic>Tumors</topic><topic>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Morrison, Larry E.</creatorcontrib><creatorcontrib>Jacobson, Kristine K.</creatorcontrib><creatorcontrib>Friedman, Michael</creatorcontrib><creatorcontrib>Schroeder, James W.</creatorcontrib><creatorcontrib>Coon, John S.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>ComDisDome</collection><jtitle>The Laryngoscope</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Morrison, Larry E.</au><au>Jacobson, Kristine K.</au><au>Friedman, Michael</au><au>Schroeder, James W.</au><au>Coon, John S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Aberrant EGFR and Chromosome 7 Associate with Outcome in Laryngeal Cancer</atitle><jtitle>The Laryngoscope</jtitle><addtitle>The Laryngoscope</addtitle><date>2005-07</date><risdate>2005</risdate><volume>115</volume><issue>7</issue><spage>1212</spage><epage>1218</epage><pages>1212-1218</pages><issn>0023-852X</issn><eissn>1531-4995</eissn><coden>LARYA8</coden><abstract>Objectives/Hypothesis: Epidermal growth factor receptor (EGFR) over‐expression has been reported as a prognostic indicator in laryngeal cancer; however, the association with disease outcome has been inconsistent among studies. Here, we use fluorescence in situ hybridization (FISH) in addition to immunohistochemistry to assess laryngeal squamous cell carcinoma (SCC) to determine whether FISH can better predict patient outcome.
Study Design: Retrospective study on 59 patients presenting with advanced disease.
Methods:
EGFR and chromosome 7 genomic statuses were measured using FISH, and EGFR expression was assessed by immunohistochemistry on formalin‐fixed, paraffin‐embedded specimens and correlated with outcome in the 59 patients.
Results: EGFR expression was marginally associated with outcome, whereas both EGFR and chromosome 7 FISH status were significantly associated with outcome, and the combination of EGFR and chromosome 7 FISH status provided the strongest association of any two combined parameters (P = .0004). Combining EGFR expression with EGFR and chromosome 7 FISH status provided further improvement (P > .0001).
Conclusions: Measurements of EGFR and chromosome 7 FISH status, and to a lesser extent EGFR expression, have potential value in treatment planning for patients with laryngeal SCC.</abstract><cop>Hoboken, NJ</cop><pub>John Wiley & Sons, Inc</pub><pmid>15995509</pmid><doi>10.1097/01.MLG.0000163755.21035.8F</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Biological and medical sciences Chromosome Aberrations Chromosomes, Human, Pair 7 - genetics Female Genes, erbB-1 - genetics Humans In Situ Hybridization, Fluorescence Laryngeal Neoplasms - genetics Laryngeal Neoplasms - mortality Laryngeal Neoplasms - pathology Male Medical sciences Middle Aged Neoplasm Staging Otorhinolaryngology. Stomatology Prognosis Retrospective Studies Survival Rate Tumors Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology |
| title | Aberrant EGFR and Chromosome 7 Associate with Outcome in Laryngeal Cancer |
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