Inhibition of carbachol-evoked oscillatory currents by the NO donor sodium nitroprusside in guinea-pig ileal myocytes

The effect of sodium nitroprusside (SNP) on carbachol (CCh)-evoked inward cationic current ( I cat ) oscillations in guinea-pig ileal longitudinal myocytes was investigated using the whole-cell patch-clamp technique and permeabilized longitudinal muscle strips. SNP (10 Î¼ m ) completely inhibited I...

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Veröffentlicht in:	Experimental physiology 2005-07, Vol.90 (4), p.577-586
Hauptverfasser:	Chung, Seung‐Soo, Ahn, Duck‐Sun, Lee, Hong‐Ghi, Lee, Young‐Ho, Nam, Taick‐Sang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Caffeine - pharmacology Carbachol - antagonists & inhibitors Carbachol - pharmacology Chelating Agents - pharmacology Cyclic GMP - analogs & derivatives Cyclic GMP - pharmacology Cyclic GMP-Dependent Protein Kinases - physiology Egtazic Acid - analogs & derivatives Egtazic Acid - pharmacology Guinea Pigs Ileum - drug effects Ileum - physiology In Vitro Techniques Membrane Potentials - drug effects Muscarinic Agonists - pharmacology Muscle Contraction - drug effects Muscle Contraction - physiology Myocytes, Smooth Muscle - drug effects Myocytes, Smooth Muscle - physiology Nitric Oxide Donors - pharmacology Nitroprusside - pharmacology Oxadiazoles - pharmacology Patch-Clamp Techniques Phosphatidylinositol 3-Kinases - pharmacology Phosphodiesterase Inhibitors - pharmacology Quinoxalines - pharmacology Type C Phospholipases - pharmacology
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