The KPNA3 gene may be a susceptibility candidate for schizophrenia
The present study investigated the possible association of the KPNA3 locus in the 13q14 region with schizophrenia. We detected 7 single nucleotide polymorphisms (SNPs) on 13q14, one (rs6313) present at the HTR2A locus and the other 6 at the KPNA3 locus, among 124 British family trios consisting of m...
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| Veröffentlicht in: | Neuroscience research 2005-08, Vol.52 (4), p.342-346 |
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| creator | Wei, Jun Hemmings, Gwynneth P. |
| description | The present study investigated the possible association of the KPNA3 locus in the 13q14 region with schizophrenia. We detected 7 single nucleotide polymorphisms (SNPs) on 13q14, one (rs6313) present at the HTR2A locus and the other 6 at the KPNA3 locus, among 124 British family trios consisting of mother, father and affected offspring with schizophrenia. The transmission disequilibrium test (TDT) showed allelic association for rs3736830 (
χ
2
=
8.66,
P
=
0.003), rs2181185 (
χ
2
=
3.86,
P
=
0.049) and rs626716 (
χ
2
=
5.82,
P
=
0.016), but not for rs6313 (
χ
2
=
0.009,
P
=
0.926). The global
P-value was 0.029 for 1000 permutations with the TDT. The 2-SNP haplotype analysis showed a disease association for the rs2273816-rs3736830 haplotypes (
χ
2
=
7.63, d.f.
=
2,
P
=
0.022), the rs3736830-rs2181185 haplotypes (
χ
2
=
10.30, d.f.
=
2,
P
=
0.006) and the rs2181185-rs3782929 haplotypes (
χ
2
=
9.26, d.f.
=
2,
P
=
0.01). The global
P-value was 0.034 for 1000 permutations with the 2-SNP haplotype analysis. The 6-SNP haplotype system also showed a weak association with the illness (
χ
2
=
15.62, d.f.
=
8,
P
=
0.048), although the 1-d.f. test did not show the association for nine individual haplotypes when a
P-value was corrected by the Bonferroni corrections. The present study suggests that the KPNA3 may contribute genetically to schizophrenia in a small effect size. |
| doi_str_mv | 10.1016/j.neures.2005.04.005 |
| format | Article |
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χ
2
=
8.66,
P
=
0.003), rs2181185 (
χ
2
=
3.86,
P
=
0.049) and rs626716 (
χ
2
=
5.82,
P
=
0.016), but not for rs6313 (
χ
2
=
0.009,
P
=
0.926). The global
P-value was 0.029 for 1000 permutations with the TDT. The 2-SNP haplotype analysis showed a disease association for the rs2273816-rs3736830 haplotypes (
χ
2
=
7.63, d.f.
=
2,
P
=
0.022), the rs3736830-rs2181185 haplotypes (
χ
2
=
10.30, d.f.
=
2,
P
=
0.006) and the rs2181185-rs3782929 haplotypes (
χ
2
=
9.26, d.f.
=
2,
P
=
0.01). The global
P-value was 0.034 for 1000 permutations with the 2-SNP haplotype analysis. The 6-SNP haplotype system also showed a weak association with the illness (
χ
2
=
15.62, d.f.
=
8,
P
=
0.048), although the 1-d.f. test did not show the association for nine individual haplotypes when a
P-value was corrected by the Bonferroni corrections. The present study suggests that the KPNA3 may contribute genetically to schizophrenia in a small effect size.</description><identifier>ISSN: 0168-0102</identifier><identifier>EISSN: 1872-8111</identifier><identifier>DOI: 10.1016/j.neures.2005.04.005</identifier><identifier>PMID: 15882913</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Adult ; Alleles ; alpha Karyopherins - genetics ; Association study ; Chi-Square Distribution ; Chromosome 13 ; Family Health ; Female ; Gene Frequency - genetics ; Genetic Predisposition to Disease ; Haplotypes ; HTR2A ; Humans ; KPNA3 ; Male ; Polymorphism, Restriction Fragment Length ; Polymorphism, Single Nucleotide ; Schizophrenia ; Schizophrenia - genetics ; Single nucleotide polymorphisms (SNPs)</subject><ispartof>Neuroscience research, 2005-08, Vol.52 (4), p.342-346</ispartof><rights>2005 Elsevier Ireland Ltd and the Japan Neuroscience Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c413t-40b0910e0c73cef61380dd3e678c98cb17c91e572ebcfcf2833008e31b62d30c3</citedby><cites>FETCH-LOGICAL-c413t-40b0910e0c73cef61380dd3e678c98cb17c91e572ebcfcf2833008e31b62d30c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0168010205001069$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15882913$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wei, Jun</creatorcontrib><creatorcontrib>Hemmings, Gwynneth P.</creatorcontrib><title>The KPNA3 gene may be a susceptibility candidate for schizophrenia</title><title>Neuroscience research</title><addtitle>Neurosci Res</addtitle><description>The present study investigated the possible association of the KPNA3 locus in the 13q14 region with schizophrenia. We detected 7 single nucleotide polymorphisms (SNPs) on 13q14, one (rs6313) present at the HTR2A locus and the other 6 at the KPNA3 locus, among 124 British family trios consisting of mother, father and affected offspring with schizophrenia. The transmission disequilibrium test (TDT) showed allelic association for rs3736830 (
χ
2
=
8.66,
P
=
0.003), rs2181185 (
χ
2
=
3.86,
P
=
0.049) and rs626716 (
χ
2
=
5.82,
P
=
0.016), but not for rs6313 (
χ
2
=
0.009,
P
=
0.926). The global
P-value was 0.029 for 1000 permutations with the TDT. The 2-SNP haplotype analysis showed a disease association for the rs2273816-rs3736830 haplotypes (
χ
2
=
7.63, d.f.
=
2,
P
=
0.022), the rs3736830-rs2181185 haplotypes (
χ
2
=
10.30, d.f.
=
2,
P
=
0.006) and the rs2181185-rs3782929 haplotypes (
χ
2
=
9.26, d.f.
=
2,
P
=
0.01). The global
P-value was 0.034 for 1000 permutations with the 2-SNP haplotype analysis. The 6-SNP haplotype system also showed a weak association with the illness (
χ
2
=
15.62, d.f.
=
8,
P
=
0.048), although the 1-d.f. test did not show the association for nine individual haplotypes when a
P-value was corrected by the Bonferroni corrections. The present study suggests that the KPNA3 may contribute genetically to schizophrenia in a small effect size.</description><subject>Adult</subject><subject>Alleles</subject><subject>alpha Karyopherins - genetics</subject><subject>Association study</subject><subject>Chi-Square Distribution</subject><subject>Chromosome 13</subject><subject>Family Health</subject><subject>Female</subject><subject>Gene Frequency - genetics</subject><subject>Genetic Predisposition to Disease</subject><subject>Haplotypes</subject><subject>HTR2A</subject><subject>Humans</subject><subject>KPNA3</subject><subject>Male</subject><subject>Polymorphism, Restriction Fragment Length</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Schizophrenia</subject><subject>Schizophrenia - genetics</subject><subject>Single nucleotide polymorphisms (SNPs)</subject><issn>0168-0102</issn><issn>1872-8111</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1OwzAQhC0EoqXwBgj5xC1hN04T54JUKv5EBRzK2UqcDXWVJsVOkMrT4yqVuHGayzezO8PYJUKIgMnNOmyot-TCCGAaQhx6OWJjlGkUSEQ8ZmOPyQAQohE7c24NACKLxSkb4VTKKEMxZnfLFfGX99eZ4J_UEN_kO14Qz7nrnaZtZwpTm27Hdd6Upsw74lVrudMr89NuV5Yak5-zkyqvHV0cdMI-Hu6X86dg8fb4PJ8tAh2j6IIYCsgQCHQqNFUJCgllKShJpc6kLjDVGdI0jajQla4iKQSAJIFFEpUCtJiw6yF3a9uvnlynNsb_WNd5Q23vVJJmma8FHowHUNvWOUuV2lqzye1OIaj9dmqthu3UfjsFsfLibVeH_L7YUPlnOozlgdsBIN_y25BVThtqNJXGku5U2Zr_L_wCrdaA5Q</recordid><startdate>20050801</startdate><enddate>20050801</enddate><creator>Wei, Jun</creator><creator>Hemmings, Gwynneth P.</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050801</creationdate><title>The KPNA3 gene may be a susceptibility candidate for schizophrenia</title><author>Wei, Jun ; Hemmings, Gwynneth P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c413t-40b0910e0c73cef61380dd3e678c98cb17c91e572ebcfcf2833008e31b62d30c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Alleles</topic><topic>alpha Karyopherins - genetics</topic><topic>Association study</topic><topic>Chi-Square Distribution</topic><topic>Chromosome 13</topic><topic>Family Health</topic><topic>Female</topic><topic>Gene Frequency - genetics</topic><topic>Genetic Predisposition to Disease</topic><topic>Haplotypes</topic><topic>HTR2A</topic><topic>Humans</topic><topic>KPNA3</topic><topic>Male</topic><topic>Polymorphism, Restriction Fragment Length</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Schizophrenia</topic><topic>Schizophrenia - genetics</topic><topic>Single nucleotide polymorphisms (SNPs)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wei, Jun</creatorcontrib><creatorcontrib>Hemmings, Gwynneth P.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wei, Jun</au><au>Hemmings, Gwynneth P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The KPNA3 gene may be a susceptibility candidate for schizophrenia</atitle><jtitle>Neuroscience research</jtitle><addtitle>Neurosci Res</addtitle><date>2005-08-01</date><risdate>2005</risdate><volume>52</volume><issue>4</issue><spage>342</spage><epage>346</epage><pages>342-346</pages><issn>0168-0102</issn><eissn>1872-8111</eissn><abstract>The present study investigated the possible association of the KPNA3 locus in the 13q14 region with schizophrenia. We detected 7 single nucleotide polymorphisms (SNPs) on 13q14, one (rs6313) present at the HTR2A locus and the other 6 at the KPNA3 locus, among 124 British family trios consisting of mother, father and affected offspring with schizophrenia. The transmission disequilibrium test (TDT) showed allelic association for rs3736830 (
χ
2
=
8.66,
P
=
0.003), rs2181185 (
χ
2
=
3.86,
P
=
0.049) and rs626716 (
χ
2
=
5.82,
P
=
0.016), but not for rs6313 (
χ
2
=
0.009,
P
=
0.926). The global
P-value was 0.029 for 1000 permutations with the TDT. The 2-SNP haplotype analysis showed a disease association for the rs2273816-rs3736830 haplotypes (
χ
2
=
7.63, d.f.
=
2,
P
=
0.022), the rs3736830-rs2181185 haplotypes (
χ
2
=
10.30, d.f.
=
2,
P
=
0.006) and the rs2181185-rs3782929 haplotypes (
χ
2
=
9.26, d.f.
=
2,
P
=
0.01). The global
P-value was 0.034 for 1000 permutations with the 2-SNP haplotype analysis. The 6-SNP haplotype system also showed a weak association with the illness (
χ
2
=
15.62, d.f.
=
8,
P
=
0.048), although the 1-d.f. test did not show the association for nine individual haplotypes when a
P-value was corrected by the Bonferroni corrections. The present study suggests that the KPNA3 may contribute genetically to schizophrenia in a small effect size.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>15882913</pmid><doi>10.1016/j.neures.2005.04.005</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0168-0102 |
| ispartof | Neuroscience research, 2005-08, Vol.52 (4), p.342-346 |
| issn | 0168-0102 1872-8111 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67998820 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adult Alleles alpha Karyopherins - genetics Association study Chi-Square Distribution Chromosome 13 Family Health Female Gene Frequency - genetics Genetic Predisposition to Disease Haplotypes HTR2A Humans KPNA3 Male Polymorphism, Restriction Fragment Length Polymorphism, Single Nucleotide Schizophrenia Schizophrenia - genetics Single nucleotide polymorphisms (SNPs) |
| title | The KPNA3 gene may be a susceptibility candidate for schizophrenia |
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