Reduced endocannabinoid immune modulation by a common cannabinoid 2 (CB2) receptor gene polymorphism: possible risk for autoimmune disorders

Immune system responsiveness results from numerous factors, including endogenous cannabinoid signaling in immunocytes termed the “immunocannabinoid” system. This system can be an important signaling pathway for immune modulation. To assess the immunomodulating role of the cannabinoid 2 (CB2) recepto...

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Veröffentlicht in:	Journal of leukocyte biology 2005-07, Vol.78 (1), p.231-238
Hauptverfasser:	Sipe, Jack C., Arbour, Nathalie, Gerber, Alexandra, Beutler, Ernest
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution - genetics Arachidonic Acids - immunology Arachidonic Acids - metabolism Arachidonic Acids - pharmacology Autoimmune Diseases - drug therapy Autoimmune Diseases - genetics Autoimmune Diseases - immunology autoimmunity Cannabinoid Receptor Modulators - immunology Cannabinoid Receptor Modulators - metabolism Cannabinoid Receptor Modulators - pharmacology Cell Proliferation - drug effects Cells, Cultured DNA Mutational Analysis Down-Regulation - genetics Down-Regulation - immunology Endocannabinoids endogenous cannabinoid Gene Frequency - genetics Genetic Predisposition to Disease - genetics genetic variation Glycerides - immunology Glycerides - metabolism Glycerides - pharmacology Glycine - analogs & derivatives Glycine - immunology Glycine - metabolism Glycine - pharmacology Homozygote Humans Immunologic Factors - immunology Immunologic Factors - metabolism Immunologic Factors - pharmacology immunomodulation Immunosuppression - methods Immunosuppression - trends Lymphocyte Activation - drug effects Lymphocyte Activation - immunology Mutation - genetics Polymorphism, Genetic - genetics Receptor, Cannabinoid, CB2 - agonists Receptor, Cannabinoid, CB2 - antagonists & inhibitors Receptor, Cannabinoid, CB2 - genetics T-Lymphocytes - drug effects T-Lymphocytes - immunology
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