The effects of short-term oral phytoestrogen supplementation on the hypothalamic-pituitary-testicular axis in prostate cancer patients
Background Here we evaluate the effects of oral phytoestrogen supplementation on hypothalamic‐pituitary‐testicular (HPT) axis in CaP patients. Methods We recruited 40 men about to undergo radical prostatectomy for CaP to receive either 240 mg of clover phytoestrogens or placebo daily for 2 weeks. Se...
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| Veröffentlicht in: | The Prostate 2006-07, Vol.66 (10), p.1086-1091 |
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| creator | Rannikko, Antti Petas, Anssi Raivio, Taneli Jänne, Olli A. Rannikko, Sakari Adlercreutz, Herman |
| description | Background
Here we evaluate the effects of oral phytoestrogen supplementation on hypothalamic‐pituitary‐testicular (HPT) axis in CaP patients.
Methods
We recruited 40 men about to undergo radical prostatectomy for CaP to receive either 240 mg of clover phytoestrogens or placebo daily for 2 weeks. Serum hormone levels were measured before and after treatment. In addition, recombinant cell bioassay was used to measure serum androgen bioactivity (ABA).
Results
Phytoestrogen treatment increased serum LH from mean of 3.4–5.2 IU, P = 0.03. Concomitantly, non‐significant trend towards decline in serum T, cfT and ABA values was noted. However, mean serum LH/T ratio was upregulated from 0.20 to 0.48 IU/nM, P = 0.004, suggesting compensated hypogonadism. During the course of treatment, serum concentration of equol correlated strongly with the concomitant decrease in ABA (r = −0.586, P = 0.022).
Conclusions
Phytoestrogen treatment interferes with HPT axis in CaP patients by inducing testicular resistance to LH and compensated hypogonadism. Prostate 66: 1086‐1091, 2006. © 2006 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/pros.20437 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67997945</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>67997945</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3957-b173f21d6db02814290a0078e92a2f71659304dedcbbed6074231276cccb9cdc3</originalsourceid><addsrcrecordid>eNp9kM2KFDEUhYMoTju68QEkG10INd4kVUlnKY2OwtAj2iK4CanULStaf5OkcPoFfG7TduvshEA23zn3nEPIUwYXDIC_msMULziUQt0jKwZaFQBldZ-sgCsoSibUGXkU43eAjAN_SM6YlEKBqlbk165Dim2LLkU6tTR2U0hFwjDQKdiezt0-TRhTmL7hSOMyzz0OOCab_DTS_FLWd_t5Sp3t7eBdMfu0-GTDPrvE5N3S20DtrY_Uj_QQNWuROjs6DHTOPtktPiYPWttHfHL6z8nnt292m3fF1fXl-83rq8IJXamiZkq0nDWyqYGvWck1WAC1Rs0tbxWTlRZQNti4usZGgiq5YFxJ51ytXePEOXlx9M1Bbpaczww-Oux7O-K0RCOV1kqXVQZfHkGXE8eArZmDH3Irw8AcVjeHKubP6hl-dnJd6gGbO_Q0cwaenwAbne3bkNv7eMeptda61JljR-6n73H_n5Pmw8frT3-PF0eNjwlv_2ls-JHbCFWZL9tLI7XcbvlmZ76K3_rYrS0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>67997945</pqid></control><display><type>article</type><title>The effects of short-term oral phytoestrogen supplementation on the hypothalamic-pituitary-testicular axis in prostate cancer patients</title><source>Wiley Online Library - AutoHoldings Journals</source><source>MEDLINE</source><creator>Rannikko, Antti ; Petas, Anssi ; Raivio, Taneli ; Jänne, Olli A. ; Rannikko, Sakari ; Adlercreutz, Herman</creator><creatorcontrib>Rannikko, Antti ; Petas, Anssi ; Raivio, Taneli ; Jänne, Olli A. ; Rannikko, Sakari ; Adlercreutz, Herman</creatorcontrib><description>Background
Here we evaluate the effects of oral phytoestrogen supplementation on hypothalamic‐pituitary‐testicular (HPT) axis in CaP patients.
Methods
We recruited 40 men about to undergo radical prostatectomy for CaP to receive either 240 mg of clover phytoestrogens or placebo daily for 2 weeks. Serum hormone levels were measured before and after treatment. In addition, recombinant cell bioassay was used to measure serum androgen bioactivity (ABA).
Results
Phytoestrogen treatment increased serum LH from mean of 3.4–5.2 IU, P = 0.03. Concomitantly, non‐significant trend towards decline in serum T, cfT and ABA values was noted. However, mean serum LH/T ratio was upregulated from 0.20 to 0.48 IU/nM, P = 0.004, suggesting compensated hypogonadism. During the course of treatment, serum concentration of equol correlated strongly with the concomitant decrease in ABA (r = −0.586, P = 0.022).
Conclusions
Phytoestrogen treatment interferes with HPT axis in CaP patients by inducing testicular resistance to LH and compensated hypogonadism. Prostate 66: 1086‐1091, 2006. © 2006 Wiley‐Liss, Inc.</description><identifier>ISSN: 0270-4137</identifier><identifier>EISSN: 1097-0045</identifier><identifier>DOI: 10.1002/pros.20437</identifier><identifier>PMID: 16637075</identifier><identifier>CODEN: PRSTDS</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Administration, Oral ; Aged ; androgen ; Androgens - blood ; bioactivity ; Biological and medical sciences ; daidzein ; Dose-Response Relationship, Drug ; Double-Blind Method ; equol ; genistein ; Gynecology. Andrology. Obstetrics ; Humans ; Hypogonadism - etiology ; Hypogonadism - physiopathology ; Hypothalamus - drug effects ; Hypothalamus - physiopathology ; Luteinizing Hormone - blood ; Luteinizing Hormone - physiology ; Male ; Male genital diseases ; Medical sciences ; Middle Aged ; Nephrology. Urinary tract diseases ; Phytoestrogens - administration & dosage ; Phytoestrogens - pharmacology ; Phytoestrogens - therapeutic use ; Pituitary Gland - drug effects ; Pituitary Gland - physiopathology ; Prospective Studies ; prostate cancer ; Prostatic Neoplasms - blood ; Prostatic Neoplasms - drug therapy ; Prostatic Neoplasms - physiopathology ; Testis - drug effects ; Testis - physiopathology ; Testosterone - blood ; Tumors ; Tumors of the urinary system ; Urinary tract. Prostate gland</subject><ispartof>The Prostate, 2006-07, Vol.66 (10), p.1086-1091</ispartof><rights>Copyright © 2006 Wiley‐Liss, Inc.</rights><rights>2006 INIST-CNRS</rights><rights>Copyright 2005 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3957-b173f21d6db02814290a0078e92a2f71659304dedcbbed6074231276cccb9cdc3</citedby><cites>FETCH-LOGICAL-c3957-b173f21d6db02814290a0078e92a2f71659304dedcbbed6074231276cccb9cdc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fpros.20437$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fpros.20437$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27929,27930,45579,45580</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17899949$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16637075$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rannikko, Antti</creatorcontrib><creatorcontrib>Petas, Anssi</creatorcontrib><creatorcontrib>Raivio, Taneli</creatorcontrib><creatorcontrib>Jänne, Olli A.</creatorcontrib><creatorcontrib>Rannikko, Sakari</creatorcontrib><creatorcontrib>Adlercreutz, Herman</creatorcontrib><title>The effects of short-term oral phytoestrogen supplementation on the hypothalamic-pituitary-testicular axis in prostate cancer patients</title><title>The Prostate</title><addtitle>Prostate</addtitle><description>Background
Here we evaluate the effects of oral phytoestrogen supplementation on hypothalamic‐pituitary‐testicular (HPT) axis in CaP patients.
Methods
We recruited 40 men about to undergo radical prostatectomy for CaP to receive either 240 mg of clover phytoestrogens or placebo daily for 2 weeks. Serum hormone levels were measured before and after treatment. In addition, recombinant cell bioassay was used to measure serum androgen bioactivity (ABA).
Results
Phytoestrogen treatment increased serum LH from mean of 3.4–5.2 IU, P = 0.03. Concomitantly, non‐significant trend towards decline in serum T, cfT and ABA values was noted. However, mean serum LH/T ratio was upregulated from 0.20 to 0.48 IU/nM, P = 0.004, suggesting compensated hypogonadism. During the course of treatment, serum concentration of equol correlated strongly with the concomitant decrease in ABA (r = −0.586, P = 0.022).
Conclusions
Phytoestrogen treatment interferes with HPT axis in CaP patients by inducing testicular resistance to LH and compensated hypogonadism. Prostate 66: 1086‐1091, 2006. © 2006 Wiley‐Liss, Inc.</description><subject>Administration, Oral</subject><subject>Aged</subject><subject>androgen</subject><subject>Androgens - blood</subject><subject>bioactivity</subject><subject>Biological and medical sciences</subject><subject>daidzein</subject><subject>Dose-Response Relationship, Drug</subject><subject>Double-Blind Method</subject><subject>equol</subject><subject>genistein</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Hypogonadism - etiology</subject><subject>Hypogonadism - physiopathology</subject><subject>Hypothalamus - drug effects</subject><subject>Hypothalamus - physiopathology</subject><subject>Luteinizing Hormone - blood</subject><subject>Luteinizing Hormone - physiology</subject><subject>Male</subject><subject>Male genital diseases</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Phytoestrogens - administration & dosage</subject><subject>Phytoestrogens - pharmacology</subject><subject>Phytoestrogens - therapeutic use</subject><subject>Pituitary Gland - drug effects</subject><subject>Pituitary Gland - physiopathology</subject><subject>Prospective Studies</subject><subject>prostate cancer</subject><subject>Prostatic Neoplasms - blood</subject><subject>Prostatic Neoplasms - drug therapy</subject><subject>Prostatic Neoplasms - physiopathology</subject><subject>Testis - drug effects</subject><subject>Testis - physiopathology</subject><subject>Testosterone - blood</subject><subject>Tumors</subject><subject>Tumors of the urinary system</subject><subject>Urinary tract. Prostate gland</subject><issn>0270-4137</issn><issn>1097-0045</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM2KFDEUhYMoTju68QEkG10INd4kVUlnKY2OwtAj2iK4CanULStaf5OkcPoFfG7TduvshEA23zn3nEPIUwYXDIC_msMULziUQt0jKwZaFQBldZ-sgCsoSibUGXkU43eAjAN_SM6YlEKBqlbk165Dim2LLkU6tTR2U0hFwjDQKdiezt0-TRhTmL7hSOMyzz0OOCab_DTS_FLWd_t5Sp3t7eBdMfu0-GTDPrvE5N3S20DtrY_Uj_QQNWuROjs6DHTOPtktPiYPWttHfHL6z8nnt292m3fF1fXl-83rq8IJXamiZkq0nDWyqYGvWck1WAC1Rs0tbxWTlRZQNti4usZGgiq5YFxJ51ytXePEOXlx9M1Bbpaczww-Oux7O-K0RCOV1kqXVQZfHkGXE8eArZmDH3Irw8AcVjeHKubP6hl-dnJd6gGbO_Q0cwaenwAbne3bkNv7eMeptda61JljR-6n73H_n5Pmw8frT3-PF0eNjwlv_2ls-JHbCFWZL9tLI7XcbvlmZ76K3_rYrS0</recordid><startdate>20060701</startdate><enddate>20060701</enddate><creator>Rannikko, Antti</creator><creator>Petas, Anssi</creator><creator>Raivio, Taneli</creator><creator>Jänne, Olli A.</creator><creator>Rannikko, Sakari</creator><creator>Adlercreutz, Herman</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20060701</creationdate><title>The effects of short-term oral phytoestrogen supplementation on the hypothalamic-pituitary-testicular axis in prostate cancer patients</title><author>Rannikko, Antti ; Petas, Anssi ; Raivio, Taneli ; Jänne, Olli A. ; Rannikko, Sakari ; Adlercreutz, Herman</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3957-b173f21d6db02814290a0078e92a2f71659304dedcbbed6074231276cccb9cdc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Administration, Oral</topic><topic>Aged</topic><topic>androgen</topic><topic>Androgens - blood</topic><topic>bioactivity</topic><topic>Biological and medical sciences</topic><topic>daidzein</topic><topic>Dose-Response Relationship, Drug</topic><topic>Double-Blind Method</topic><topic>equol</topic><topic>genistein</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Hypogonadism - etiology</topic><topic>Hypogonadism - physiopathology</topic><topic>Hypothalamus - drug effects</topic><topic>Hypothalamus - physiopathology</topic><topic>Luteinizing Hormone - blood</topic><topic>Luteinizing Hormone - physiology</topic><topic>Male</topic><topic>Male genital diseases</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Phytoestrogens - administration & dosage</topic><topic>Phytoestrogens - pharmacology</topic><topic>Phytoestrogens - therapeutic use</topic><topic>Pituitary Gland - drug effects</topic><topic>Pituitary Gland - physiopathology</topic><topic>Prospective Studies</topic><topic>prostate cancer</topic><topic>Prostatic Neoplasms - blood</topic><topic>Prostatic Neoplasms - drug therapy</topic><topic>Prostatic Neoplasms - physiopathology</topic><topic>Testis - drug effects</topic><topic>Testis - physiopathology</topic><topic>Testosterone - blood</topic><topic>Tumors</topic><topic>Tumors of the urinary system</topic><topic>Urinary tract. Prostate gland</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rannikko, Antti</creatorcontrib><creatorcontrib>Petas, Anssi</creatorcontrib><creatorcontrib>Raivio, Taneli</creatorcontrib><creatorcontrib>Jänne, Olli A.</creatorcontrib><creatorcontrib>Rannikko, Sakari</creatorcontrib><creatorcontrib>Adlercreutz, Herman</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Prostate</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rannikko, Antti</au><au>Petas, Anssi</au><au>Raivio, Taneli</au><au>Jänne, Olli A.</au><au>Rannikko, Sakari</au><au>Adlercreutz, Herman</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effects of short-term oral phytoestrogen supplementation on the hypothalamic-pituitary-testicular axis in prostate cancer patients</atitle><jtitle>The Prostate</jtitle><addtitle>Prostate</addtitle><date>2006-07-01</date><risdate>2006</risdate><volume>66</volume><issue>10</issue><spage>1086</spage><epage>1091</epage><pages>1086-1091</pages><issn>0270-4137</issn><eissn>1097-0045</eissn><coden>PRSTDS</coden><abstract>Background
Here we evaluate the effects of oral phytoestrogen supplementation on hypothalamic‐pituitary‐testicular (HPT) axis in CaP patients.
Methods
We recruited 40 men about to undergo radical prostatectomy for CaP to receive either 240 mg of clover phytoestrogens or placebo daily for 2 weeks. Serum hormone levels were measured before and after treatment. In addition, recombinant cell bioassay was used to measure serum androgen bioactivity (ABA).
Results
Phytoestrogen treatment increased serum LH from mean of 3.4–5.2 IU, P = 0.03. Concomitantly, non‐significant trend towards decline in serum T, cfT and ABA values was noted. However, mean serum LH/T ratio was upregulated from 0.20 to 0.48 IU/nM, P = 0.004, suggesting compensated hypogonadism. During the course of treatment, serum concentration of equol correlated strongly with the concomitant decrease in ABA (r = −0.586, P = 0.022).
Conclusions
Phytoestrogen treatment interferes with HPT axis in CaP patients by inducing testicular resistance to LH and compensated hypogonadism. Prostate 66: 1086‐1091, 2006. © 2006 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>16637075</pmid><doi>10.1002/pros.20437</doi><tpages>6</tpages></addata></record> |
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| subjects | Administration, Oral Aged androgen Androgens - blood bioactivity Biological and medical sciences daidzein Dose-Response Relationship, Drug Double-Blind Method equol genistein Gynecology. Andrology. Obstetrics Humans Hypogonadism - etiology Hypogonadism - physiopathology Hypothalamus - drug effects Hypothalamus - physiopathology Luteinizing Hormone - blood Luteinizing Hormone - physiology Male Male genital diseases Medical sciences Middle Aged Nephrology. Urinary tract diseases Phytoestrogens - administration & dosage Phytoestrogens - pharmacology Phytoestrogens - therapeutic use Pituitary Gland - drug effects Pituitary Gland - physiopathology Prospective Studies prostate cancer Prostatic Neoplasms - blood Prostatic Neoplasms - drug therapy Prostatic Neoplasms - physiopathology Testis - drug effects Testis - physiopathology Testosterone - blood Tumors Tumors of the urinary system Urinary tract. Prostate gland |
| title | The effects of short-term oral phytoestrogen supplementation on the hypothalamic-pituitary-testicular axis in prostate cancer patients |
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