Cooperation between platelet-derived CD154 and CD4+ T cells for enhanced germinal center formation

It has been demonstrated previously that platelet‐derived CD154 communicates with the adaptive immune compartment, enhancing B and T cell responses in CD154−/− mice. The presence of platelets was also shown to be necessary for optimal production of immunoglobulin G (IgG) in normal C57BL/6 mice. Thes...

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Veröffentlicht in:	Journal of leukocyte biology 2005-07, Vol.78 (1), p.80-84
Hauptverfasser:	Elzey, Bennett D., Grant, Julieann F., Sinn, Haley W., Nieswandt, Bernhard, Waldschmidt, Thomas J., Ratliff, Timothy L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibody Formation - immunology B cells B-Lymphocytes - immunology Blood Platelets - immunology CD4-Positive T-Lymphocytes - immunology CD40 Ligand - immunology Cell Communication - immunology Epitopes - immunology Germinal Center - cytology Germinal Center - immunology humoral immunity Immunity, Cellular - immunology Immunity, Innate - immunology Immunoglobulin G - biosynthesis Immunoglobulin G - blood Immunoglobulin G - immunology innate immunity knockout Lymphoid Tissue - cytology Lymphoid Tissue - immunology Mice Mice, Inbred C57BL Mice, Knockout mouse Signal Transduction - immunology Up-Regulation - immunology
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