Cooperation between platelet-derived CD154 and CD4+ T cells for enhanced germinal center formation
It has been demonstrated previously that platelet‐derived CD154 communicates with the adaptive immune compartment, enhancing B and T cell responses in CD154−/− mice. The presence of platelets was also shown to be necessary for optimal production of immunoglobulin G (IgG) in normal C57BL/6 mice. Thes...
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| Veröffentlicht in: | Journal of leukocyte biology 2005-07, Vol.78 (1), p.80-84 |
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| container_title | Journal of leukocyte biology |
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| creator | Elzey, Bennett D. Grant, Julieann F. Sinn, Haley W. Nieswandt, Bernhard Waldschmidt, Thomas J. Ratliff, Timothy L. |
| description | It has been demonstrated previously that platelet‐derived CD154 communicates with the adaptive immune compartment, enhancing B and T cell responses in CD154−/− mice. The presence of platelets was also shown to be necessary for optimal production of immunoglobulin G (IgG) in normal C57BL/6 mice. These data led us to hypothesize that platelets perform a sentinel function, quickly relaying activating signals to the adaptive immune compartment. Here, we report that platelet‐derived CD154 increases serum IgG levels and germinal center formation under conditions where antigen‐specific CD4+ T cell numbers are limiting. We propose that in the physiologic setting where antigen‐specific B and T cells are rare, platelets function to enhance signals required for robust adaptive humoral immunity. |
| doi_str_mv | 10.1189/jlb.1104669 |
| format | Article |
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The presence of platelets was also shown to be necessary for optimal production of immunoglobulin G (IgG) in normal C57BL/6 mice. These data led us to hypothesize that platelets perform a sentinel function, quickly relaying activating signals to the adaptive immune compartment. Here, we report that platelet‐derived CD154 increases serum IgG levels and germinal center formation under conditions where antigen‐specific CD4+ T cell numbers are limiting. We propose that in the physiologic setting where antigen‐specific B and T cells are rare, platelets function to enhance signals required for robust adaptive humoral immunity.</description><identifier>ISSN: 0741-5400</identifier><identifier>EISSN: 1938-3673</identifier><identifier>DOI: 10.1189/jlb.1104669</identifier><identifier>PMID: 15899982</identifier><language>eng</language><publisher>United States: Society for Leukocyte Biology</publisher><subject>Animals ; Antibody Formation - immunology ; B cells ; B-Lymphocytes - immunology ; Blood Platelets - immunology ; CD4-Positive T-Lymphocytes - immunology ; CD40 Ligand - immunology ; Cell Communication - immunology ; Epitopes - immunology ; Germinal Center - cytology ; Germinal Center - immunology ; humoral immunity ; Immunity, Cellular - immunology ; Immunity, Innate - immunology ; Immunoglobulin G - biosynthesis ; Immunoglobulin G - blood ; Immunoglobulin G - immunology ; innate immunity ; knockout ; Lymphoid Tissue - cytology ; Lymphoid Tissue - immunology ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; mouse ; Signal Transduction - immunology ; Up-Regulation - immunology</subject><ispartof>Journal of leukocyte biology, 2005-07, Vol.78 (1), p.80-84</ispartof><rights>2005 Society for Leukocyte Biology</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3570-8e53feade8b137609e4384079cb561d0798ed57a9add0ebb27bdd2fc5bb8d00e3</citedby><cites>FETCH-LOGICAL-c3570-8e53feade8b137609e4384079cb561d0798ed57a9add0ebb27bdd2fc5bb8d00e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1189%2Fjlb.1104669$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1189%2Fjlb.1104669$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15899982$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Elzey, Bennett D.</creatorcontrib><creatorcontrib>Grant, Julieann F.</creatorcontrib><creatorcontrib>Sinn, Haley W.</creatorcontrib><creatorcontrib>Nieswandt, Bernhard</creatorcontrib><creatorcontrib>Waldschmidt, Thomas J.</creatorcontrib><creatorcontrib>Ratliff, Timothy L.</creatorcontrib><title>Cooperation between platelet-derived CD154 and CD4+ T cells for enhanced germinal center formation</title><title>Journal of leukocyte biology</title><addtitle>J Leukoc Biol</addtitle><description>It has been demonstrated previously that platelet‐derived CD154 communicates with the adaptive immune compartment, enhancing B and T cell responses in CD154−/− mice. The presence of platelets was also shown to be necessary for optimal production of immunoglobulin G (IgG) in normal C57BL/6 mice. These data led us to hypothesize that platelets perform a sentinel function, quickly relaying activating signals to the adaptive immune compartment. Here, we report that platelet‐derived CD154 increases serum IgG levels and germinal center formation under conditions where antigen‐specific CD4+ T cell numbers are limiting. We propose that in the physiologic setting where antigen‐specific B and T cells are rare, platelets function to enhance signals required for robust adaptive humoral immunity.</description><subject>Animals</subject><subject>Antibody Formation - immunology</subject><subject>B cells</subject><subject>B-Lymphocytes - immunology</subject><subject>Blood Platelets - immunology</subject><subject>CD4-Positive T-Lymphocytes - immunology</subject><subject>CD40 Ligand - immunology</subject><subject>Cell Communication - immunology</subject><subject>Epitopes - immunology</subject><subject>Germinal Center - cytology</subject><subject>Germinal Center - immunology</subject><subject>humoral immunity</subject><subject>Immunity, Cellular - immunology</subject><subject>Immunity, Innate - immunology</subject><subject>Immunoglobulin G - biosynthesis</subject><subject>Immunoglobulin G - blood</subject><subject>Immunoglobulin G - immunology</subject><subject>innate immunity</subject><subject>knockout</subject><subject>Lymphoid Tissue - cytology</subject><subject>Lymphoid Tissue - immunology</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Knockout</subject><subject>mouse</subject><subject>Signal Transduction - immunology</subject><subject>Up-Regulation - immunology</subject><issn>0741-5400</issn><issn>1938-3673</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kL1PwzAQxS0EgvIxsaMMiKUKnOMktkco36rEArNlxxca5CTFTon473FpJTame9L93rvTI-SUwiWlQl59OBMF5GUpd8iESiZSVnK2SybAc5oWOcABOQzhAwBYVsI-OaCFkFKKbELMrO-X6PXQ9F1icBgRu2Tp9IAOh9Sib77QJrNbWuSJ7tYqnyavSYXOhaTufYLdQndVZN7Rt02nXdx1A_r1sv2NPSZ7tXYBT7bziLzd373OHtP5y8PT7HqeVqzgkAosWI3aojCU8RIk5kzkwGVlipLaKATagmuprQU0JuPG2qyuCmOEBUB2RC42uUvff64wDKptwvpR3WG_CqrkUnLOsghON2Dl-xA81mrpm1b7b0VBrStVsVK1rTTSZ9vYlWnR_rHbDiMAG2BsHH7_l6We5zcAAqLlfGNZNO-LsfGoQqudixcyNY4jF4qqiP0AiLSNnQ</recordid><startdate>200507</startdate><enddate>200507</enddate><creator>Elzey, Bennett D.</creator><creator>Grant, Julieann F.</creator><creator>Sinn, Haley W.</creator><creator>Nieswandt, Bernhard</creator><creator>Waldschmidt, Thomas J.</creator><creator>Ratliff, Timothy L.</creator><general>Society for Leukocyte Biology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200507</creationdate><title>Cooperation between platelet-derived CD154 and CD4+ T cells for enhanced germinal center formation</title><author>Elzey, Bennett D. ; Grant, Julieann F. ; Sinn, Haley W. ; Nieswandt, Bernhard ; Waldschmidt, Thomas J. ; Ratliff, Timothy L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3570-8e53feade8b137609e4384079cb561d0798ed57a9add0ebb27bdd2fc5bb8d00e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Animals</topic><topic>Antibody Formation - immunology</topic><topic>B cells</topic><topic>B-Lymphocytes - immunology</topic><topic>Blood Platelets - immunology</topic><topic>CD4-Positive T-Lymphocytes - immunology</topic><topic>CD40 Ligand - immunology</topic><topic>Cell Communication - immunology</topic><topic>Epitopes - immunology</topic><topic>Germinal Center - cytology</topic><topic>Germinal Center - immunology</topic><topic>humoral immunity</topic><topic>Immunity, Cellular - immunology</topic><topic>Immunity, Innate - immunology</topic><topic>Immunoglobulin G - biosynthesis</topic><topic>Immunoglobulin G - blood</topic><topic>Immunoglobulin G - immunology</topic><topic>innate immunity</topic><topic>knockout</topic><topic>Lymphoid Tissue - cytology</topic><topic>Lymphoid Tissue - immunology</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Knockout</topic><topic>mouse</topic><topic>Signal Transduction - immunology</topic><topic>Up-Regulation - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Elzey, Bennett D.</creatorcontrib><creatorcontrib>Grant, Julieann F.</creatorcontrib><creatorcontrib>Sinn, Haley W.</creatorcontrib><creatorcontrib>Nieswandt, Bernhard</creatorcontrib><creatorcontrib>Waldschmidt, Thomas J.</creatorcontrib><creatorcontrib>Ratliff, Timothy L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of leukocyte biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Elzey, Bennett D.</au><au>Grant, Julieann F.</au><au>Sinn, Haley W.</au><au>Nieswandt, Bernhard</au><au>Waldschmidt, Thomas J.</au><au>Ratliff, Timothy L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cooperation between platelet-derived CD154 and CD4+ T cells for enhanced germinal center formation</atitle><jtitle>Journal of leukocyte biology</jtitle><addtitle>J Leukoc Biol</addtitle><date>2005-07</date><risdate>2005</risdate><volume>78</volume><issue>1</issue><spage>80</spage><epage>84</epage><pages>80-84</pages><issn>0741-5400</issn><eissn>1938-3673</eissn><abstract>It has been demonstrated previously that platelet‐derived CD154 communicates with the adaptive immune compartment, enhancing B and T cell responses in CD154−/− mice. The presence of platelets was also shown to be necessary for optimal production of immunoglobulin G (IgG) in normal C57BL/6 mice. These data led us to hypothesize that platelets perform a sentinel function, quickly relaying activating signals to the adaptive immune compartment. Here, we report that platelet‐derived CD154 increases serum IgG levels and germinal center formation under conditions where antigen‐specific CD4+ T cell numbers are limiting. We propose that in the physiologic setting where antigen‐specific B and T cells are rare, platelets function to enhance signals required for robust adaptive humoral immunity.</abstract><cop>United States</cop><pub>Society for Leukocyte Biology</pub><pmid>15899982</pmid><doi>10.1189/jlb.1104669</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; Access via Wiley Online Library; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Antibody Formation - immunology B cells B-Lymphocytes - immunology Blood Platelets - immunology CD4-Positive T-Lymphocytes - immunology CD40 Ligand - immunology Cell Communication - immunology Epitopes - immunology Germinal Center - cytology Germinal Center - immunology humoral immunity Immunity, Cellular - immunology Immunity, Innate - immunology Immunoglobulin G - biosynthesis Immunoglobulin G - blood Immunoglobulin G - immunology innate immunity knockout Lymphoid Tissue - cytology Lymphoid Tissue - immunology Mice Mice, Inbred C57BL Mice, Knockout mouse Signal Transduction - immunology Up-Regulation - immunology |
| title | Cooperation between platelet-derived CD154 and CD4+ T cells for enhanced germinal center formation |
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