Brain uptake of nonsteroidal anti-inflammatory drugs : Ibuprofen, flurbiprofen, and indomethacin

To determine the roles of blood-brain barrier (BBB) transport and plasma protein binding in brain uptake of nonsteroidal anti-inflammatory drugs (NSAIDs)-ibuprofen, flurbiprofen, and indomethacin. Brain uptake was measured using in situ rat brain perfusion technique. [14C]Ibuprofen, [3H]flurbiprofen...

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Veröffentlicht in:	Pharmaceutical research 2006-05, Vol.23 (5), p.873-881
Hauptverfasser:	PAREPALLY, Jagan Mohan R, MANDULA, Haritha, SMITH, Quentin R
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Animals Anti-inflammatory agents Anti-Inflammatory Agents, Non-Steroidal - metabolism Binding, Competitive Biological and medical sciences Biological Transport Blood-Brain Barrier - metabolism Brain - metabolism Capillary Permeability Carotid arteries Flurbiprofen - metabolism General pharmacology Ibuprofen - metabolism Indomethacin - metabolism Kinetics Laboratories Male Medical sciences Nonsteroidal anti-inflammatory drugs Perfusion Pharmaceutical technology. Pharmaceutical industry Pharmaceuticals Pharmacology. Drug treatments Plasma Protein Binding Proteins Rats Rats, Wistar Serum Albumin, Bovine - metabolism
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