Expression of ecto-5'-nucleotidase (eN, CD73) in cell lines from various stages of human melanoma

Ecto-5'-nucleotidase is a GPI-anchored enzyme localized in cell membrane lipid rafts. Although it is highly expressed in many tumour cells, its specific function during tumorigenesis is unclear. We have found that, among different melanoma cells, upregulated expression of ecto-5'-nucleotid...

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Veröffentlicht in:	Melanoma research 2006-06, Vol.16 (3), p.213-222
Hauptverfasser:	Sadej, Rafal, Spychala, Jozef, Skladanowski, Andrzej C
Format:	Artikel
Sprache:	eng
Schlagworte:	5'-Nucleotidase - antagonists & inhibitors 5'-Nucleotidase - biosynthesis 5'-Nucleotidase - metabolism Cell Adhesion - physiology Cell Line, Tumor Centrifugation, Density Gradient Concanavalin A - pharmacology Extracellular Matrix Proteins - metabolism Humans Hyaluronan Receptors - metabolism Integrin alpha3 - metabolism Iohexol - chemistry Melanocytes - enzymology Melanocytes - metabolism Melanoma - enzymology Melanoma - pathology Membrane Microdomains - enzymology Membrane Microdomains - metabolism Membrane Proteins - biosynthesis Membrane Proteins - metabolism Neoplasm Staging Tenascin - metabolism
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